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Education & Training


Postdoctoral Research Fellow, Developmental Biology Program, Sloan Kettering Institute (lab of Kat Hadjantonakis)


PhD degree in microbiology and immunology, Temple University School of Medicine, Philadelphia, PA  (lab of Patrick J. Piggot)

Thesis title: “Twin spore formation within one mother cell by Bacillus subtilis”


BS degree in molecular biology and genetics, Democritus University of Thrace, Greece

Research Interests

My interests are to understand how cell fate decisions are made, and in particular how changes in gene expression influence fate choices during development. As a graduate student, my studies are focused on understanding how gene expression regulates cell fate in individual bacterial cells during the process of Bacillus subtilis sporulation, which is considered a model for prokaryotic development and cellular differentiation.

My current work continues to focus on understanding how cell fate is specified, albeit in the mouse as a mammalian model system. Live imaging is an essential tool to observe how fate decisions are made in living organisms and in live stem cell cultures. I am currently generating various fluorescent reporter expressing mouse strains in order to image live cells in developing pre-implantation mouse embryos and embryo-derived stem cells.

The central goal of my ongoing studies is to determine how gene expression might influence the decision a stem cell or lineage progenitor makes to differentiate or self-renew.

Publications by Panos Xenopoulos

Chary, V.K., Xenopoulos, P., Piggot, P.J. (2006) Blocking chromosome translocation during sporulation of Bacillus subtilis can result in prespore-specific activation of sG that is independent of sE and of engulfment. Journal of Bacteriology 188:7267-7273..

Bogush, M., Xenopoulos, P., Piggot, P.J. (2007) Separation of chromosome termini during sporulation of Bacillus subtilis depends on SpoIIIE. Journal of Bacteriology 189:3564-3572.

Chary, V.K., Xenopoulos, P., Piggot, P.J. (2007) Expression of the sF -directed csfB locus prevents premature appearance of sG activity during sporulation of Bacillus subtilis. Journal of Bacteriology 189:8754-8757.

Eldar, A.*, Chary, V.K.*, Xenopoulos, P., Fontes, M.E., Losón, O.C., Dworkin, J., Piggot, P.J., Elowitz, M.B. (2009) Partial penetrance facilitates developmental evolution in bacteria. Nature. 460:510-514.

Chary, V.K., Xenopoulos, P., Eldar, A., Piggot, P.J. (2010) Loss of compartmentalization of sE activity need not impair formation of spores by Bacillus subtilis. Journal of Bacteriology 192:5616-5624..

Xenopoulos, P., Piggot, P.J. (2010) Regulation of chromosome replication and growth of the mother cell during sporulation of Bacillus subtilis. Journal of Bacteriology 193:3117-3126.

Xenopoulos, P., Nowotschin, S. and Hadjantonakis, A.-K. (2012) Live imaging fluorescent proteins in early mouse embryos. Methods in Enzymology. 506:361-389.

Xenopoulos, P., Kang, M. and Hadjantonakis, A.-K. (2012) Lineage commitment in the inner cell mass of the mouse blastocyst. Results and Problems in Cell Differentiation. 55:185-202.

Xenopoulos P*, Schrode N*, Piliszek A, Frankenberg S, Plusa B, Hadjantonakis, A.-K. (2013) Anatomy of a blastocyst: Cell behaviors driving cell fate choice and morphogenesis in the early mouse embryo. Genesis. Journal in Process.

Nowotschin S, Xenopoulos P, Schrode N, Hadjantonakis A.-K. (2013) A bright single-cell resolution live imaging reporter of Notch signaling in the mouse. BMC Developmental Biology 13(1):15.

* Equal authorship.