(I) The morphogenesis of the early mammalian embryo.

Elucidating the cellular and molecular mechanisms underlying embryo growth, differentiation and patterning.

(II) Lineage specification and embryo-derived stem cells.

Identifying stem and progenitor cell populations resident within the early mammalian embryo and investigating the reprogramming of differentiated cells.

(III) The generation of tools and development of methods for in vivo imaging.

The visualization of live cell behaviors operating in situ combined with the power of mouse genetics towards understanding the mechanisms regulating embryonic development, homeostasis and disease progression in mammals.