Our lab investigates the fundamental evolutionary mechanisms underlying metastasis using pancreatic cancer as our model tumor type. Metastasis is the result of a series of biological hurdles subject to Darwinian selection including the birth of metastasis-enabled cells within a heterogeneous primary tumor microenvironment, intravasation of these cells into a functional vascular bed, survival in the circulation, extravasation from the vasculature, and establishment of an autonomous cell population within the newly encountered foreign microenvironment.


Heterogeneity of pancreatic cancer metastases in a single patient revealed by quantitative proteomics. Kim MS, Zhong Y, Yachida S, Rajeshkumar NV, Abel ML, Marimuthu A, Mudgal K, Hruban RH, Poling JS, Tyner JW, Maitra A, Iacobuzio-Donahue CA*, Pandey A. Mol Cell Proteomics. 2014 Jun 3. pii: mcp.M114.038547. *co-senior author

Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors. Yachida S, White CM, Naito Y, Zhong Y, Brosnan JA, Macgregor-Das AM, Morgan RA, Saunders T, Laheru DA, Herman JM, Hruban RH, Klein AP, Jones S, Velculescu V, Wolfgang CL, Iacobuzio-Donahue CA. Clin Cancer Res. 2012 Nov 15;18(22):6339-47.

Computational modeling of pancreatic cancer reveals kinetics of metastasis suggesting optimum treatment strategies. Haeno H, Gonen M, Davis MB, Herman JM, Iacobuzio-Donahue CA*, Michor F. Cell. 2012 Jan 20;148(1-2):362-75. *co-senior author

Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B, Kamiyama M, Hruban RH, Eshleman JR, Nowak MA, Velculescu VE, Kinzler KW, Vogelstein B, Iacobuzio-Donahue CA. Nature. 2010 Oct 28;467(7319):1114-7.

DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. Iacobuzio-Donahue CA, Fu B, Yachida S, Luo M, Abe H, Henderson CM, Vilardell F, Wang Z, Keller JW, Banerjee P, Herman JM, Cameron JL, Yeo CJ, Halushka MK, Eshleman JR, Raben M, Klein AP, Hruban RH, Hidalgo M, Laheru D. J Clin Oncol. 2009 Apr 10;27(11):1806-13. 

View Christine A. Iacobuzio-Donahue’s physician profile.
Selected Achievements

Team Science Award, American Association for Cancer Research (2012)

Ramzi Cotran Young Investigator Award, United States and Canadian Academy of Pathology (2009)

AACR-Barletta Foundation Career Development Award in Translational Pancreatic Cancer Research (2005)

Member, Alpha Omega Alpha (2002)