A postdoctoral position is available for highly motivated candidates with a background in molecular/cellular biology and/or genetics to join a research group interested in identifying molecular mechanisms that regulate normal and diseased stem cells in the hematopoietic system. We hypothesize that normal hematopoietic stem/progenitor cells accumulate multiple genetic/epigenetic “hits” during leukemogenesis; therefore, isolation of pre-leukemic stem/progenitor cell intermediates will be critical to dissecting the processes of disease initiation, progression, transformation, and maintenance, as well as identifying the cell population targeted for transformation.
The candidate will identify microRNAs and/or mRNAs that regulate normal and malignant stem cells by comparing highly-purified disease stem/progenitor cells to their normal counterparts during leukemic progression. Disorders of interest include acute leukemias and myelodysplastic syndromes. Evaluation of gene function will include the use of in vitro assays and mouse models; however, special emphasis will be placed on increasing the relevance of experimental findings to human disease by validating potential therapeutic targets using primary patient samples and in vivo xenotransplantation models.
Applicants should hold a PhD and/or MD degree and have strong laboratory and analytical skills as well as a willingness to work with animals. Prior experience in hematopoietic/leukemia stem cell biology, microRNAs, or bioinformatics would be very helpful.
Informal inquiries may be made to Christine Mullane at email@example.com.