Mitochondrial dysfunction is associated with multiple pathologies including Parkinson’s disease, cancer, bacterial infection, and metabolic disorders as well as general aging. We investigate how cells adapt to survive mitochondrial dysfunction, primarily focusing on an intracellular signaling pathway known as the mitochondrial unfolded protein response (UPRmt).

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Selected Achievements

Bristol-Myers Squibb/James D. Robinson III Junior Faculty Chair (2014)

Boyer Award in Basic Research (2014)

Ellison Medical Foundation New Scholar in Aging (2011)

Gerstner Young Investigator (2010)

Alfred W. Bressler Scholar (2010)

At Work: Cell Biologist Cole Haynes

At Work: Cell Biologist Cole Haynes

Cell biologist Cole Haynes studies the stress responses that cells naturally mount to protect and maintain mitochondria.