Molecular Pharmacology Program

The Daniel Heller Lab

Daniel A. Heller, PhD

Member, Molecular Pharmacology Program, SKI

Cancer Nanomedicine Laboratory

We are a biomedical engineering laboratory that develops nanotechnologies to advance breakthroughs in the research, diagnosis, and treatment of cancer and allied diseases. We develop drug delivery technologies to target therapies to disease sites, advanced diagnostics to detect disease at earlier stages, and nanosensors to accelerate the discovery of new therapies. Please check out our recent innovations using the “View Lab Overview” button below…

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Research Projects

VIDEO | 02:10

Go inside the lab of Daniel Heller from SKI’s Molecular Pharmacology Program.

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Featured News

SKI biomedical engineer Dr. Daniel Heller

Getting Drugs Across the Blood-Brain Barrier Using Nanoparticles

Learn how MSK researchers are investigating the use of nanoparticles to carry drugs across the blood-brain barrier.

A Sensor Sniffs for Cancer, Using Artificial Intelligence

By detecting molecular signatures in the blood, the sensor may help improve cancer screenings.

To Detect Ovarian Cancer Early, Researchers Look to Nanotechnology

Could an implantable IUD help detect cancer early, when it is most curable? Scientists at the Sloan Kettering Institute are betting yes.

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Publications Highlights

D Tylawsky, H Kiguchi, J Vaynshteyn, J Gerwin, J Shah, T. Islam, J Boyer, D Boué, M Snuderl, M Greenblatt, Y Shamay, P Raju, DA Heller*, “P-selectin-targeted nanocarriers induce active crossing of the blood–brain barrier via caveolin-1-dependent transcytosis. Nature Materials. 22,391-399 (2023).

Highlighted in: MSK News and Nature Materials News & Views

M Kim, C Chen, P Wang, JJ Mulvey, Y Yang, C Wun, M Antman-Passig, H-B Luo, S Cho, K Long-Roche, LV Ramanathan, A Jagota, M Zheng, Y Wang, DA Heller*. “Machine-Learning-Based Detection of an Ovarian Cancer Disease Fingerprint from Serum via Quantum Defect-Modified Carbon Nanotube Arrays.” Nature Biomedical Engineering (2022). https://www.mskcc.org/news/sensor-sniffs-cancer-using-artificial-intelligence

Z Yaari, Y Yang, E Apfelbaum, C Cupo, A Settle, Q Cullen, W Cai, K Long Roche, DA Levine, M Fleisher, L Ramanathan, M Zheng, A Jagota, DA Heller*. ”A Perception-Based Machine-Perception Nanosensor Platform to Detect Cancer Biomarkers.” Science Advances 7 (2021) eabj0852. MSK News: https://www.mskcc.org/news/detect-ovarian-cancer-early-researchers-look-nanotechnology

J Budhathoki-Uprety, J Shah, JA Korsen, AE Wayne, TV Galassi, JR Cohen, JD Harvey, PV Jena, LV Ramanathan, EA Jaimes, DA Heller*. “Synthetic Molecular Recognition Nanosensor Paint for Microalbuminuria.” Nature Communications 10 (2019) 3605.
[MSK News: https://www.mskcc.org/news/science-meets-art-produce-diagnostic-test-us…]

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People

Daniel A. Heller, PhD

Member, Molecular Pharmacology Program, SKI

Biomedical engineer Daniel Heller is Head of the Cancer Nanotechnology Laboratory, which invents disruptive technologies to revolutionize the diagnosis and treatment of cancer and allied diseases.
PhD, University of Illinois at Urbana-Champaign

[email protected]: Email Address
646-888-3419: Office Phone
Download CV: PDF File

Members

Daniel A. Heller, PhD — Daniel A. Heller
Lab Head

Philip Asamani
Graduate Student, CUNY Chemistry PhD Program

Naxhije Berisha
CUNY Chemistry/Nanotechnology PhD Program Student

Atena Farahpour
CUNY Chemistry/Nanotechnology PhD Program Student

Dana Goerzen
Graduate Student, Weill Cornell PBSB PhD Program

Takeshi Irie
Assistant Attending, Anesthesiology and Critical Care

Arianna Izawa-Ishiguro
Pharmacology PhD Graduate Student

Erin Keblish
Graduate Student, Weill Cornell PBSB PhD Program

Mijin Kim
Postdoctoral Research Associate

Quincey LaPlant
Assistant Attending L1, Radiation Oncology

Magdalini Panagiotakopoulos
Postdoctoral Research Associate

Raashed Raziuddin
Graduate Student, Weill Cornell Pharmacology PhD Program

Ashley Sullivan

MSK Bridge Program Scholar

Kristen Vogt
Tri-institutional PhD Program in Chemical Biology

Laura Wilson
Senior SKI Administrative Assistant

Jaina Wollowitz
Graduate student, Tri-Institutional PhD Program in Chemical Biology

Lab Alumni

Merav Antman-Passig
Postdoctoral Research Fellow

Elana Apfelbaum
Graduate Student, Weill Cornell Pharmacology PhD Program

Hanan Baker
Resident in Anesthesiology, Bonica Scholars Program, University of Washington

Gavin Black
Associate Consultant, Triangle Insights Group, LLC

Januka Budhathoki-Uprety, PhD — Januka Budhathoki-Uprety
Assistant Professor, North Carolina State University

Chen Chen
Postdoctoral Fellow, Genentech

Christian Cupo
Graduate Student, Columbia University

Ron Feiner
Equity Research Associate - Medical Devices at Oppenheimer & Co. Inc

Rune Frederiksen
Platform Scientist, Zoetis Denmark

Thomas Galassi
Managing Director, Investor Communications at LifeSci Advisors LLC

Emma Grabarnik
Scientist I, Nanotechnology Characterization Laboratory, National Cancer Institute, National Institutes of Health

Declan Gwynne
Senior Research Technician

Prakrit Jena, PhD — Prakrit Jena
CTO, Lime Therapeutics, Inc.

Brian J. Joseph
Healey ALS Scholar at Columbia University Irving Medical Center

Hiro Kiguchi
Attending Physician, Division of Oncology, Children's Hospital of Philadelphia

Jaclyn Kubala
Scientist I, SalioGen Therapeutics

Pictured: Rachel Langenbacher — Rachel Langenbacher
Associate Medical Writer – PPD

Mandana T. Manzari
Business Development at Resilience

Ewelina Randall
Associate Scientist, Merck

Daniel Roxbury
Associate Professor, University of Rhode Island

Yosef Shamay
Assistant Professor, Faculty of Biomedical Engineering, Technion-Israel Institute of Technology

Maria Sirenko
Postdoctoral Fellow, NYU Langone, New York, NY

Ramya Sridharan
Sr. Assoc. - Prescient Healthcare Group

Daniel Tylawsky
Senior Scientist, Regeneron

Jasmine Wallas — Jas Wallas
Patent Agent at Smith Baluch LLP

Ryan Williams, PhD — Ryan Williams
Assistant Professor, CCNY

Zvi Yaari, PhD — Zvi Yaari
Assistant Professor, School of Pharmacy, Department of Medicine, Hebrew University of Jerusalem, Israel

Lab Affiliations

Achievements

American Institute for Medical and Biological Engineering (AIMBE) Fellow (2021)
Pharmacology Teaching and Mentoring Award, Weill Cornell Graduate School (2020)
American Cancer Society Research Scholar (2018)
NSF CAREER Award (2018)
Pershing Square Sohn Prize for Young Innovators in Cancer Research (2017)

NIH Director’s New Innovator Award (2012)
Damon Runyon Cancer Research Foundation Postdoctoral Fellowship (2010)
Beckman Institute Graduate Fellowship (2006)

Lab News & Events

Upcoming event

Microenvironment actuated CAR T cells improve solid tumor efficacy without toxicity

Wednesday, May 22, 2024 - 12:45 PM to 2:45 PM

View all upcoming events

Accolades

Team Recognitions

Congratulations to Atena Farahpour - awarded the Fall 2023 NanoBioNYC student award in Biomedical Materials!
Congratulations to Dr. Mijin Kim for being selected as a 2023 STAT Wunderkind! The award recognizes the work of early-career scientists and clinicians.
Congratulations to Chen Chen on the Best Poster Award at the 19th Annual Tri-institutional Chemical Biology Symposium!
Congratulations to Mijin Kim on winning the 2023 MSK Postdoctoral Researcher Award!
Congratulations to Dr. Mijin Kim - NIH K99/R00 awardee!
Congratulations to Naxhije Berisha - Tow Fellowship Awardee!
Congratulations to Dr. Mijin Kim - Kravis WiSE Postdoctoral Fellowship Winner!
Congratulations to Stephen Ruiz - awarded the MERIT Mandel Graduate Fellowship!
Congratulations to Magdalini Panagiotakopoulos – Tow Postdoctoral Fellowship Awardee!
Congratulations to Dr. Mijin Kim – MIT Technology Review 35 Under 35 Innovator!
Congratulations to Magdalini Panagiotakopoulos on winning the Controlled Release Society Poster Prize
Congratulations to Erin Keblish on winning the 2023 Electrochemical Society Best Poster Award for Industrial/Applied Science
Congratulations to Magdalini Panagiotakopoulos for winning 2nd place and the People's Choice Award in the 2023 MSK Postdoc Slam
Congratulations to Stephen Ruiz for winning the 63rd International Conference on the Bioscience of Lipids Oral Communication Award!!
Congratulations to Mijin Kim for winning the 2023 STAT Wunderkind Award!!

https://twitter.com/HellerLab

Get in Touch

[email protected]

Lab Head Email
646-888-3419

Office Phone

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Daniel A. Heller discloses the following relationships and financial interests:

Concarlo Therapeutics, Inc.
Professional Services and Activities
Lime Therapeutics, Inc.
Equity; Fiduciary Role / Position; Professional Services and Activities (Uncompensated)
Mediphage Bioceuticals, Inc.
Equity; Professional Services and Activities (Uncompensated)

Nanorobotics, Inc.
Equity
Resident Diagnostics, Inc.
Equity; Professional Services and Activities (Uncompensated)
Selectin Therapeutics, Inc.
Equity; Professional Services and Activities (Uncompensated)

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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