Complete Publications (Graphical Abstracts)

Read up on the latest publications in diversity-oriented synthesis, rational drug design, and chemical biology research from the Tan Lab!

            Selected Publications:
            Complete Publications:

Text Only | Graphical Abstracts
Text Only | Graphical Abstracts

Full-text versions of articles are available from the publisher with online journal subscription. PubMed Central (PMC) versions of articles are available free of charge.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | Postdoctoral | Graduate | Undergraduate ]

Tan Lab Publications

  1. Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice.
    Lun, S.; Guo, H.; Adamson, J.; Cisar, J. S.; Davis, T. D.; Sundaramn Chavadi, S.; Warren, J. D.; Quadri, L. E. N.*; Tan, D. S.*; Bishai, W. R.* Antimicrob. Agents Chemother. 2013, 57, 5138–5140.
    Abstract | PubMed  ]
    AAC 2013 graphical abstract, Antimicrobial Agents and Chemotherapy

  2. Diversifying complexity.
    Sharma, I.; Tan, D. S.* Nat. Chem. 2013, 5, 157–158.
    Abstract | PubMed  ]
    NCHEM 2013 graphical abstract, Nature Chemistry

  3. Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion.
    Bauer, R. A.; Wenderski, T. A.; Tan, D. S.* Nat. Chem. Biol. 2013, 9, 21–29.
    Abstract | PubMed | PMC ]
    NCB 2013 graphical abstract, Nature Chemical Biology

  4. Stereoselective synthesis of acortatarins A and B.
    Wurst, J. M.; Verano, A. L.; Tan, D. S.* Org. Lett. 2012, 14, 4442–4445.
    Abstract | PubMed | PMC ]
    OL 2012 graphical abstract, Organic Letters v2

  5. A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion.
    Kopp, F.; Stratton, C. F.; Akella, L. B.; Tan, D. S.* Nat. Chem. Biol. 2012, 8, 358–365.
    Abstract | PubMed | PMC ]
    NCB 2012a graphical abstract, Nature Chemical Biology

    (Highlighted in SciBX )

  6. Stable analogues of OSB-AMP: Potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquninone biosynthesis.
    Lu, X.; Zhou, R.; Sharma, I.; Li, X.; Kumar, G.; Swaminathan, S.; Tonge, P. J.*; Tan, D. S.* ChemBioChem 2012, 13, 129–136.
    Abstract | PubMed | PMC ]
    CBC 2012 graphical abstract, ChemBioChem

  7. Hydrogen-bonding catalysis and inhibition by simple solvents in the stereoselective kinetic epoxide-opening spirocyclization of glycal epoxides to form spiroketals.
    Wurst, J. M.; Liu, G.; Tan, D. S.* J. Am. Chem. Soc. 2011, 133, 7916–7925.
    Abstract | PubMed | PMC ]
    JACS 2011 graphical abstract, Journal of the American Chemical Society

  8. Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library.
    Moura-Letts, G.; DiBlasi, C. M.; Bauer, R. A.; Tan, D. S.* Proc. Natl. Acad. Sci. USA 2011, 108, 6745–6750.
    Abstract | PubMed | PMC ]
    PNAS 2011 graphical abstract, Proceedings of the National Academy of Sciences USA

  9. The tert-butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis.
    Bauer, R. A.; DiBlasi, C. M.; Tan, D. S.* Org. Lett. 2010, 12, 2084–2087.
    Abstract | PubMed | PMC ]
    OL 2010 graphical abstract, Organic Letters

  10. Expanding the range of 'druggable' targets with natural product-based libraries: An academic perspective.
    Bauer, R. A.; Wurst, J. M.; Tan, D. S.* Curr. Opin. Chem. Biol. 2010, 14, 308–314.
    Abstract | PubMed | PMC ]
    COCB 2010 graphical abstract, Current Opinion in Chemical Biology

  11. Active site remodelling accompanies thioester bond formation in the SUMO E1.
    Olsen, S. K.; Capili. A. D.; Lu, X.; Tan, D. S.*; Lima, C. D.* Nature 2010, 463, 906–912.
    Abstract | PubMed | PMC ]
    NAT 2010 graphical abstract, Nature

    (Highlighted in Nature, Chem. Eng. News, Nat. Rev. Mol. Cell Biol., Nat. Chem. Biol., Structure, ACS Chem. Biol., and Faculty of 1000 Biology )

  12. Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.
    Lu, X.; Olsen, S. K.; Capili, A. D.; Cisar, J. S.; Lima, C. D.*; Tan, D. S.* J. Am. Chem. Soc. 2010, 132, 1748–1749.
    Abstract | PubMed | PMC ]
    JACS 2010 graphical abstract, Journal of the American Chemical Society

    (Highlighted in Chem. Eng. News, Nat. Rev. Mol. Cell Biol., ACS Chem. Biol., and Faculty of 1000 Biology )

  13. Stereoselective synthesis of benzannulated spiroketals: Influence of the aromatic ring on reactivity and conformation.
    Liu, G.; Wurst, J. M.; Tan, D. S.* Org. Lett. 2009, 11, 3670–3673.
    Abstract | PubMed | PMC ]
    OL 2009 graphical abstract, Organic Letters

  14. Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis.
    Lu, X.; Zhang, H.; Tonge, P. J.*; Tan, D. S.* Bioorg. Med. Chem. Lett. 2008, 18, 5963–5966.
    Abstract | PubMed | PMC ]
    BOMCL 2008 graphical abstract, Bioorganic and Medicinal Chemistry Letters

  15. Small molecule inhibition of microbial natural product biosynthesis – An emerging antibiotic strategy.
    Cisar, J. S.; Tan, D. S.* Chem. Soc. Rev. 2008, 37, 1320–1329.
    Abstract | PubMed | PMC ]
    CSR 2008 graphical abstract, Chemical Society Reviews

  16. Mycobacterial phenolic glycolipid virulence factor biosynthesis: Mechanism and small-molecule inhibition of polyketide chain initiation.
    Ferreras, J. A.; Stirrett, K. L.; Lu, X.; Ryu, J.-S.; Soll, C. E.; Tan, D. S.; Quadri, L. E. N.* Chem. Biol. 2008, 15, 51–61.
    Abstract | PubMed | PMC ]
    C&B 2008 graphical abstract, Chemistry and Biology

    (Highlighted in Chem. Biol. )

  17. Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules.
    Cisar, J. S.; Ferreras, J. A.; Soni, R. K.; Quadri, L. E. N.*; Tan, D. S.* J. Am. Chem. Soc. 2007, 129, 7752–7753.
    Abstract | PubMed | PMC ]
    JACS 2007 graphical abstract, Journal of the American Chemical Society

    (Highlighted in Faculty of 1000 Biology )

  18. A unified synthetic approach to polyketides having both skeletal and stereochemical diversity.
    Shang, S.; Iwadare, H.; Macks, D. E.; Ambrosini, L. M.; Tan, D. S.* Org. Lett. 2007, 9, 1895–1898.
    Abstract | PubMed | PMC ]
    OL 2007 graphical abstract, Organic Letters

  19. Stereocontrolled synthesis of spiroketals via Ti(Oi-Pr)4-mediated kinetic spirocyclization of glycal epoxides with retention of configuration.
    Moilanen, S. B.; Potuzak, J. S.; Tan, D. S.* J. Am. Chem. Soc. 2006, 128, 1792–1793.
    Abstract | PubMed | PMC ]
    JACS 2006 graphical abstract, Journal of the American Chemical Society

    (Highlighted in Nature )

  20. Stereocontrolled synthesis of spiroketals via a remarkable methanol-induced kinetic spirocyclization reaction.
    Potuzak, J. S.; Moilanen, S. B.; Tan, D. S.* J. Am. Chem. Soc. 2005, 127, 13796–13797.
    Abstract | PubMed  ]
    JACS 2005 graphical abstract, Journal of the American Chemical Society

  21. Diversity-oriented synthesis: Exploring the intersections between chemistry and biology.
    Tan, D. S.* Nat. Chem. Biol. 2005, 1, 74–84.
    Abstract | PubMed ]
    NCB 2005i graphical abstract, Nature Chemical Biology

  22. Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis.
    Ferreras, J. A.; Ryu, J.-S.; Di Lello, F.; Tan, D. S.*, Quadri, L. E. N.* Nat. Chem. Biol. 2005, 1, 29–32.
    Abstract | PubMed ]
    NCB 2005e graphical abstract, Nature Chemical Biology

    (Highlighted in Nature, Nat. Chem. Biol., Chem. Eng. News., and Mercosur Económico )

  23. Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries.
    Shang, S.; Tan, D. S.* Curr. Opin. Chem. Biol. 2005, 9, 248–258.
    Abstract | PubMed ]
    COCB 2005 graphical abstract, Current Opinion in Chemical Biology

  24. An acid-stable tert-butyldiarylsilyl (TBDAS) linker for solid-phase organic synthesis.
    DiBlasi, C. M.; Macks, D. E.; Tan, D. S.* Org. Lett. 2005, 7, 1777–1780.
    Abstract | PubMed ]
    OL 2005 graphical abstract, Organic Letters

    (Highlighted in Lett. Org. Chem. [PDF] )

  25. Enantioselective synthesis of erythro-4-deoxyglycals as scaffolds for target- and diversity-oriented synthesis: New insights into glycal reactivity.
    Moilanen, S. B.; Tan, D. S.* Org. Biomol. Chem. 2005, 3, 798–803.
    Abstract | PubMed ]
    OBC 2005 graphical abstract, Organic and Biomolecular Chemistry

  26. Current progress in natural product-like libraries for discovery screening.
    Tan, D. S.* Comb. Chem. High-Throughput Screen. 2004, 7, 631–643.
    Abstract | PubMed ]
    CCHTS 2004 graphical abstract, Combinatorial Chemistry and High-Throughput Screening

  27. Synthesis of C1-alkyl and C1-acylglycals from glycals using a B-alkyl Suzuki–Miyaura cross coupling approach.
    Potuzak, J. S.; Tan, D. S.* Tetrahedron Lett. 2004, 45, 1797–1801.
    Abstract ]
    TL 2004 graphical abstract, Tetrahedron Letters

  28. Discovery and applications of small molecule probes for studying biological processes.
    Potuzak, J. S.; Moilanen, S. B.; Tan, D. S.* Biotechnol. Genet. Eng. Rev. 2004, 21, 11–78.
    TOC | PDF | PubMed ]
    BGER 2004 graphical abstract, Biotechnology and Genetic Engineering Reviews

  29. Sweet surrender to chemical genetics.
    Tan, D. S.* Nat. Biotechnol. 2002, 20, 561–563.
    Abstract | PubMed ]
    NBT 2002 graphical abstract, Nature Biotechnology

Postdoctoral Publications

  1. Total synthesis of guanacastepene A: A route to enantiomeric control.
    Mandal, M.; Yun, H.; Dudley, G. B.; Lin, S.; Tan, D. S.; Danishefsky, S. J.* J. Org. Chem. 2005, 70, 10619–10637.
    Abstract | PubMed ]
    JOC 2005 graphical abstract, Journal of Organic Chemistry

    (Featured on the Cover )

  2. Synthesis of the functionalized tricyclic skeleton of guanacastepene A: A tandem epoxide-opening β-elimination/Knoevenagel cyclization.
    Tan, D. S.; Dudley, G. B; Danishefsky, S. J.* Angew. Chem., Int. Ed. 2002, 41, 2185–2188.
    Abstract | PubMed ]
    ACIE 2002a graphical abstract, Angewandte Chemie International Edition

  3. A stereoselective route to guanacastepene A through a surprising epoxidation.
    Lin, S.; Dudley, G. B.; Tan, D. S.; Danishefsky, S. J.* Angew. Chem., Int. Ed. 2002, 41, 2188–2191.
    Abstract | PubMed ]
    ACIE 2002b graphical abstract, Angewandte Chemie International Edition

  4. Remarkable stereoselectivity in the alkylation of a hydroazulenone: Progress toward the total synthesis of guanacastepene.
    Dudley, G. B.; Tan, D. S.; Kim, G.; Tanski, J. M.; Danishefsky, S. J.* Tetrahedron Lett. 2001, 42, 6789–6791.
    Abstract ]
    TL 2001 graphical abstract, Tetrahedron Letters

Graduate Publications

  1. A mercury-catalyzed transetherification cyclization leading to fused cyclic polyethers.
    Tan, D. S.; Schreiber, S. L.* Tetrahedron Lett. 2000, 41, 9509–9513.
    Abstract ]
    TL 2000 graphical abstract, Tetrahedron Letters

  2. Ligand discovery using encoded combinatorial libraries.
    Tan, D. S.*; Burbaum, J. J.* Curr. Opin. Drug Discovery Dev. 2000, 3, 439–453.
    Abstract | PubMed ]
    CODDD 2000 graphical abstract, Current Opinion in Drug Discovery and Development

  3. Synthesis and preliminary evaluation of a library of polycyclic small molecules for use in chemical genetic assays.
    Tan, D. S.; Foley, M. A.; Stockwell, B. R.; Shair, M. D.; Schreiber, S. L.* J. Am. Chem. Soc. 1999, 121, 9073–9087.
    Abstract ]
    JACS 1999 graphical abstract, Journal of the American Chemical Society

  4. Stereoselective synthesis of over two million compounds having structural features both reminiscent of natural products and compatible with miniaturized cell-based assays.
    Tan, D. S.; Foley, M. A.; Shair, M. D.; Schreiber, S. L.* J. Am. Chem. Soc. 1998, 120, 8565–8566.
    Abstract ]
    JACS 1998 graphical abstract, Journal of the American Chemical Society

    (Highlighted in Science, Chem. Eng. News. )

Undergraduate Publication

  1. Enzymatic resolution coupled with substrate racemization using a thioester substrate.
    Tan, D. S.; Günter, M. M.; Drueckhammer, D. G.* J. Am. Chem. Soc. 1995, 117, 9093–9094.
    Abstract ]
    JACS 1995 graphical abstract, Journal of the American Chemical Society