Here is a list of research papers that were presented for discussion in our 2005 weekly group meetings. Papers are selected by group members as a means to broaden our knowledge in chemistry and chemical biology.

12 Dec 2005, presented by Sirkka Moilanen
Cell-specific targeting of nanoparticles by multivalent attachment of small molecules.
Weissleder, R.*; Kelly, K.; Sun, E. Y.; Shtatland, T.; Josephson, L. Nat. Biotechnol. 2005, 23, 1418-1423.
[ Abstract ]

5 Dec 2005, presented by Xuequan Lu
From nonpeptide toward noncarbon protease inhibitors: Metallacarboranes as specific and potent inhibitors of HIV protease.
Cígler, P.; Kožíšek, M.; Řezáčová, P.; Brynda, J.; Otwinowski, Z.; Pokorná, J.; Plešek, J.; Grüner, B.; Dolečková-Marešová, L.; Máša, M.; Sedláček, J.; Bodem, J.; Kräusslich, H.-G.; Král, V.; Konvalinka, J.* Proc. Natl. Acad. Sci. USA 2005, 102, 15394-15399.
[ Abstract ]

28 Nov 2005, presented by Hayato Iwadare
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.
Camps, M.; Rückle, T.; Ji, H.; Ardissone, V.; Ritelen, F.; Shaw, J.; Ferrandi, C.; Chabert, C.; Gillieron, C.; Françon, B.; Martin, T.; Gretener, D.; Perrin, D.; Leroy, D.; Vitte, P.-A.; Hirsch, E.; Wymann, M. P.; Cirillo, R.; Schwarz, M. K.; Rommel, C.* Nat. Med. 2005, 11, 936-943.
[ Abstract ]

21 Nov 2005, presented by Justin Potuzak
Small-molecule inhibition of TNF-α.
He, M. M.; Stroustrup Smith, A.; Oslob, J. D.; Flanagan, W. M.; Braisted, A. C.; Whitty, A.; Cancilla, M. T.; Wang, J.; Lugovskoy, A. A.; Yoburn, J. C.; Fung, A. D.; Farrington, G.; Eldredge, J. K.; Day, E. S.; Cruz, L. A.; Cachero, T. G.; Miller, S. K.; Friedman, J. E.; Choong, I. C.; Cunningham, B. C.* Science 2005, 310, 1022-1025.
[ Abstract ]

14 Nov 2005, presented by Justin Cisar
A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression.
Caligiuri, M.; Becker, F.; Murthi, K.; Kaplan, F.; Dedier, S.; Kaufmann, C.; Machl, A.; Zybarth, G.; Richard, J.; Bockovich, N.; Kluge, A.; Kley, N.* Chem. Biol. 2005, 12, 1103-1115.
[ Abstract ]

24 Oct 2005, presented by Christine DiBlasi
The melanocyte differentiation program predisposes to metastasis after neoplastic transformation.
Gupta, P. B.; Kuperwasser, C.; Brunet, J.-P.; Ramaswamy, S.; Kuo, W.-L.; Gray, J. W.; Naber, S. P.; Weinberg, R. A.* Nat. Genet. 2005, 37, 1047-1054.
[ Abstract ]

17 Oct 2005, presented by Shiying Shang
EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans.
Koprivica, V.; Cho, K.-S.; Park, J. B.; Yiu, G.; Atwal, J.; Gore, B.; Kim, J. A.; Lin, E.; Tessier-Lavigne, M.; Chen, D. F.; He, Z.* Science 2005, 310, 106-110.
[ Abstract ]

10 Oct 2005, presented by Sirkka Moilanen
Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling.
Evans, M. J.; Saghatelian, A.; Sorensen, E. J.; Cravatt, B. F.* Nat. Biotechnol. 2005, 23, 1303-1307.
[ Abstract ]

03 Oct 2005, presented by Hayato Iwadare
Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors.
Idris, A. I.; van't Hof, R. J.; Greig, I. R.; Ridge, S. A.; Baker, D.; Ross, R. A.; Ralston, S. H.* Nat. Med. 2005, 11, 774-779.
[ Abstract ]

26 Sep 2005, presented by Justin Potuzak
Discovery of a new peptide natural product by Streptomyces coelicolor genome mining.
Lautru, S.; Deeth, R. J.; Bailey, L. M.; Challis, G. L.* Nat. Chem. Biol. 2005, 1, 265-269.
[ Abstract ]

19 Sep 2005, presented by Christine DiBlasi
Induction of interleukin-8 preserves the angiogenic response in HIF-1α-deficient colon cancer cells.
Mizukami, Y.; Jo, W.-S.; Duerr, E.-M.; Gala, M.; Li, J.; Zhang, X.; Zimmer, M. A.; Iliopoulos, O.; Zukerberg, L. R.; Kohgo, Y.; Lynch, M. P.; Rueda, B. R.; Chung D. C.* Nat. Med. 2005, 11, 992-997.
[ Abstract ]

06 Sep 2005, presented by Justin Cisar
Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization.
Langehan, J. M.; Peters, N. R.; Guzei, I. A.; Hoffmann, F. M.; Thorson, J. S.* Proc. Natl. Acad. Sci. USA 2005, 102, 12305-12310.
[ Abstract ]

29 Aug 2005, presented by Shiying Shang
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.
Degterev, A.; Huang, Z.; Boyce, M.; Li, Y.; Jagtap, P.; Mizushima, N.; Cuny, G. D.; Mitchison, T. J.; Moskowitz, M. A.; Yuan, J.* Nat. Chem. Biol. 2005, 1, 112-119
[ Abstract ]

22 Aug 2005, presented by Sirkka Moilanen
Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system.
Sengupta, S.; Eavarone, D.; Capila, I.; Zhao, G.; Watson, N.; Kiziltepe, T.; Sasisekharan, R.* Nature 2005, 436, 568-572.
[ Abstract ]

15 Aug 2005, presented by Hayato Iwadare
Structure activity relationships and quantitative structure activity relationships for the flavonoid-mediated inhibition of breast cancer resistance protein.
Zhang, S.; Yang, X.; Coburn, R. A.; Morris, M. E.* Biochem. Pharmacol. 2005, 70, 627-639.
[ Abstract ]

8 Aug 2005, presented by Daniel Macks
Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation.
Bordeleau, M.-E.; Matthews, J.; Wojnar, J. M.; Lindqvist, L.; Novac, O.; Jankowsky, E.; Sonenberg, N.; Northcote, P.; Teesdale-Spittle, P.; Pelletier, J.* Proc. Natl. Acad. Sci. USA 2005, 102, 10460-10465.
[ Abstract ]

1 Aug 2005, presented by Justin Potuzak
Efficient synthetic inhibitors of anthrax lethal factor.
Forino, M.; Johnson, S.; Wong, T. Y.; Rozanov, D. V.; Savinov, A. Y.; Li, W.; Fattorusso, R.; Becattini, B.; Orry, A. J.; Jung, D.; Abagyan, R. A.; Smith, J. W.; Alibek, K.; Liddington, R. C.; Strongin, A. Y.; Pellecchia, M.* Proc. Natl. Acad. Sci. USA 2005, 102, 9499-9504.
[ Abstract ]

11 Jul 2005, presented by Justin Cisar
Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages.
Rengarajan, J.; Bloom, B. R.; Rubin, E. J.* Proc. Natl. Acad. Sci. USA 2005, 102, 8327-8332.
[ Abstract ]

5 July 2005, presented by Christine DiBlasi
Stat3 is required for ALK-mediated lympomagenesis and provides a possible therapeutic target.
Chiarle, R.; Simmons, W. J.; Cai, H.; Dhall, G.; Zamo, A.; Raz, R.; Karras, J. G.; Levy, D. E.; Inghirami, G.* Nat. Med. 2005, 11, 623-629.
[ Abstract ]

27 Jun 2005, presented by Shiying Shang
An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
Oltersdorf, T.; Elmore, S. W.; Shoemaker, A. R.; Armstrong, R. C.; Augeri, D. J.; Belli, B. A.; Bruncko, M.; Deckwerth, T. L.; Dinges, J.; Hajduk, P. J.; Joseph, M. K.; Kitada, S.; Korsmeyer, S. J.; Kunzer, A. R.; Letai, A.; Li, C.; Mitten, M. J.; Nettesheim, D. G.; Ng, S.; Nimmer, P. M.; O'Connor, J. M.; Oleksijew, A.; Petros, A. M.; Reed, J. C.; Shen, W.; Tahir, S. K.; Thompson, C. B.; Tomaselli, K. J.; Wang, B.; Wendt, M. D.; Zhang, H.; Fesik, S. W.*; Rosenberg, S. H.* Nature 2005, 435, 677-681
[ Abstract ]

30 May 2005, presented by Sirkka Moilanen
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors.
Song, W.; Zhu, P.; Lee, S.-K.; Chowdhury, D.; Kussman, S.; Dykxhoorn, D. M.; Feng, Y.; Palliser, D.; Weiner, D. B.; Shankar, P.; Marasco, W. A.; Lieberman, J.* Nat. Biotechnol. 2005, 23, 709-717.
[ Abstract ]

16 May 2005, presented by Hayato Iwadare
Structual basis for antagonism and resistance of bicalutamide in prostate cancer.
Bohl, C. E.; Gao, W.; Miller, D. D.; Bell, C. E.*; Dalton, J. T.* Proc. Natl. Acad. Sci. USA 2005, 102, 6201-6206.
[ Abstract ]

9 May 2005, presented by Jae-Sang Ryu
Allosteric inhibition of protein tyrosine phosphatase 1B.
Weismann, C.; Barr, K. J.; Kung, J.; Zhu, J.; Erlanson, D. A.; Shen, W.; Fahr, B. J.; Zhong, M.; Taylor, L.; Randal, M.; McDowell, R. S.; Hansen, S. K.* Nat. Struct. Mol. Biol. 2004, 11, 730-737.
[ Abstract ]

2 May 2005, presented by Justin Potuzak
Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice.
Shan, D.; Chen, L.; Njardarson, J. T.; Gaul, C.; Ma, X.; Danishefsky, S. J.; Huang, X.-Y.* Proc. Natl. Acad. Sci. USA 2005, 102, 3772-3776.
[ Abstract ]

25 Apr 2005, presented by Christine DiBlasi
A small molecule-kinase interaction map for clinical kinase inhibitors.
Fabian, M. A.; Biggs, W. H.; Treiber, D. K.; Atteridge, C. E.; Azimioara, M. D.; Benedetti, M. G.; Carter, T. A.; Ciceri, P.; Edeen, P. T.; Floyd, M.; Ford, J. M.; Galvin, M.; Gerlach, J. L.; Grotzfeld, R. M.; Herrgard, S.; Insko, D. E.; Insko, M. A.; Lai, A. G; Lélias, J.-M.; Mehta, S. A.; Milanov, Z. V.; Velasco, A. M.; Wodicka, L. M.; Patel, H. K.; Zarrinkar, P. P.*; Lockhart, D. J.* Nat. Biotechnol. 2005, 23, 329-336.
[ Abstract ]

4 Apr 2005, presented by Justin Potuzak
Combating drug-resistant bacteria: Small molecule mimics of plasmid incompatibility as antiplasmid compounds.
DeNap, J. C. B.; Thomas, J. R.; Musk, D. J.; Hergenrother, P. J.* J. Am. Chem. Soc. 2005, 126, 15402-15404.
[ Abstract ]

14 Mar 2005, presented by Justin Cisar
A non-ATP-competative inhibitor of BCR-ABL overrides imatinib resistance.
Gumireddy, K.; Baker, S. J.; Cosenza, S. C.; John, P.; Kang, A. D.; Robell, K. A.; Reddy, M. V. R.; Reddy, E. P.* Proc. Natl. Acad. Sci. USA 2005, 102, 1992-1997.
[ Abstract ]

21 Feb 2005, presented by Sirkka Moilanen
Label-free detection of small-molecule-protein interactions by using nanowire nanosensors.
Wang, W. U.; Chen, C.; Lin, K.-h.; Fang, Y.; Lieber, C. M.* Proc. Natl. Acad. Sci. USA 2005, 102, 3208-3212.
[ Abstract ]

14 Feb 2005, presented by Jae-Sang Ryu
A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design.
Card, G. L.; Blasdel, L.; England, B. P.; Zhang, C.; Suzuki, Y.; Gillette, S.; Fong, D.; Ibrahim, P. N.; Artis, D. R.; Bollag, G.; Milburn, M. V.; Kim, S.-H.; Schlessinger, J.; Zhang, K. Y. J.* Nat. Biotechnol. 2005, 23, 201-207.
[ Abstract ]

3 Jan 2005, presented by Sirkka Moilanen
Tumor imaging by means of proteolytic activation of cell-penetrating peptides.
Jiang, T.; Olson, E. S.; Nguyen, Q. T.; Roy, M.; Jennings, P. A.; Tsien, R. Y.* Proc. Natl. Acad. Sci. USA 2004, 101, 17867-17872.
[ Abstract ]