Group Meeting Papers 2008

Here is a list of research papers that were presented for discussion in our 2008 weekly group meetings. Papers are selected by group members as a means to broaden our knowledge in chemistry and chemical biology.

9 Dec 2008, presented by Xuequan Lu
Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches.
Trost, B. M.*; Dong, G. Nature 2008, 456, 485-488.
[ Abstract ]

24 Nov 2008, presented by Felix Kopp
Cross-coupling of aryl/alkenyl pivalates with organozinc reagents through nickel-catalyzed CO bond activation under mild reaction conditions.
Li, B.-J.; Li, Y.-Z.; Lu, X.-Y.; Liu, J.; Guan, B.-T.; Shi, Z.-J.* Angew. Chem. Intl. Ed. 2008, 47, 10124-10127.
[ Abstract ]

10 Nov 2008, presented by Guodong Liu
A concise asymmetric total synthesis of aspidophytine.
Nicolaou, K. C.*; Dalby, S. M.; Majumder, U. J. Am. Chem. Soc. 2008, 130, 14942-14943.
[ Abstract ]

27 Oct 2008, presented by Justin Cisar
Targeted polypharmacology: Discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
Apsel, B.; Blair, J. A.; Gonzalez, B.; Nazif, T. M.; Feldman, M. E.; Aizenstein, B.; Hoffman, R.; Williams, R. L.; Shokat, K. M.*; Knight, Z. A. Nat. Chem. Biol. 2008, 4, 691-699.
[ Abstract ]

29 Sep 2008, presented by Chris Stratton
Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening.
Schürer, S. C; Brown, S. J.; Gonzalez-Cabrera, P. J.; Schaeffer, M.-T.; Chapman, J.; Jo, E.; Chase, P.; Spicer, T.; Hodder, P.; Rosen, H* ACS Chem. Biol. 2008, 3, 486-498.
[ Abstract ]

19 Aug 2008, presented by Jackie Wurst
Biomimetic synthesis of the IDO inhibitors exiguamine A and B.
Volgraf, M; Lumb, J.-P.; Brastianos, H. C.; Carr, G. ;Chung, M. K. W.; Münzel, M.; Mauk, A. G.; Andersen, R. J.*; Trauner, D.* Nat. Chem. Biol. 2008, 4, 535-537.
[ Abstract ]

11 Aug 2008, presented by Shalini Balakrishnan
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug.
Boecker, F. M.; Joerger, A. C.; Jaggi, G.; Rutherford, T. J.; Veprintsev, D. B.; Fersht, A. R.* Proc. Natl. Acad. Sci. USA 2008, 105, 10360-10365.
[ Abstract ]

28 Jul 2008, presented by Renato Bauer
Disparate proteome reactivity profiles of carbon electrophiles.
Weerapana, E.; Simon, G. M.; Cravatt, B. F.* Nat. Chem. Biol. 2008, 4, 405-407.
[ Abstract ]

30 Jun 2008, presented by Xuequan Lu
Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity.
Xie, P.; Williams, D. S.; Atilla-Gokcumen, G. E.; Milk, L.; Xiao, M.; Smalley, K. S.; Herlyn, M.; Meggers, E.; Marmorstein, R.* ACS Chem. Biol. 2008, 3, 305-316.
[ Abstract ]

26 May 2008, presented by Felix Kopp
Nickel-catalyzed cross-coupling of aryl methyl ethers with aryl boronic esters.
Tobisu, M.; Shimasaki, T.; Chatani, N.* Angew. Chem. Intl. Ed. 2008, 47, 4866-4869.
[ Abstract ]

19 May 2008, presented by Guodong Liu
Catalytic asymmetric Michael reactions of acetaldehyde.
García-García, P.; Ladépêche, A.; Halder, R.; List, B.* Angew. Chem. Intl. Ed. 2008, 47, 4719-4721.
[ Abstract ]

Asymmetric Michael reaction of acetaldehyde catalyzed by diphenylprolinol silyl ether.
Hayashi, Y.*, Itoh, T.; Ohkubo, M.; Ishikawa, H. Angew. Chem. Intl. Ed. 2008, 47, 4722-4724.
[ Abstract ]

5 May 2008, presented by Justin Cisar
Cysteine-free peptide and glycopeptide ligation by direct aminolysis.
Payne, R. J.; Ficht, S.; Greenberg, W. A.; Wong, C.-H.* Angew. Chem. Intl. Ed. 2008, 47, 4411-4415.
[ Abstract ]

28 Apr 2008, presented by Christopher Stratton
Synthesis of 1,9-dideoxy-pre-axinellamine.
Yamaguchi, J.; Seiple, I. B.; Young, I. S.; O'Malley, D. P.; Maue, M.; Baran, P. S.* Angew. Chem. Intl. Ed. 2008, 47, 3578-3580.
[ Abstract ]

Total synthesis of (±)-axinellamines A and B.
O'Malley, D. P.; Yamaguchi, J.; Young, I. S.; Seiple, I. B.; Baran, P. S.* Angew. Chem. Intl. Ed. 2008, 47, 3581-3583.
[ Abstract ]

21 Apr 2008, presented by Shalini Balakrishnan
Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics.
Bashor, C. J.; Helman, N. C.; Yan, S.; Lim, W. A.* Science 2008, 319, 1539-1543.
[ Abstract ]

31 Mar 2008, presented by Jacqueline Wurst
Anti-MRSA agent discovery using diversity-oriented synthesis.
Thomas, G. L.; Spandl, R. J.; Glandsorp, F. G.; Welch, M.; Bender, A.; Cockfield, J.; Lindsay, J. A.; Bryant, C.; Brown, D. F. J.; Loiseleur, O.; Rudyk, H.; Ladlow, M.; Spring, D. R.* Angew. Chem. Intl. Ed. 208, 47, 2808-2812.
[ Abstract ]

17 Mar 2008, presented by Renato Bauer
Stereoretentive synthesis and chemoselective amide-forming ligations of C-terminal peptide α-ketoacids.
Ju, L.; Lippert, A. R.; Bode, J. W* J. Am. Chem. Soc. 2008, 130, 4253-4255.
[ Abstract ]

3 Mar 2008, presented by Xuequan Lu
Catalytic C-H functionalization by metal carbenoid and nitrenoid insertion.
Davies, H. M. L.*; Manning, J. R. Nature 2008, 451, 417-424.
[ Abstract ]

11 Feb 2008, presented by Christine DiBlasi
Negative regulation of the deacetylase SIRT1 by DBC1.
Zhao, W.; Kruse, J.-P.; Tang, Y.; Jung, S. Y.; Qin, J.; Gu, W.* Nature 2008, 451, 587-590.
[ Abstract ]

28 Jan 2008, presented by Felix Kopp
Oxidative cross-coupling of arenes induced by single-electron transfer leading to biaryls by use of organoiodine(III) oxidants.
Dohi, T.; Ito, M.; Morimoto, K.; Iwata, M.; Kita, Y.* Angew. Chem., Intl. Ed. 2008, 47, 1301-1304.
[ Abstract ]

15 Jan 2008, presented by Guodong Liu
A predictably selective aliphatic C-H oxidation reaction for complex molecule synthesis.
Chen, M. S.; White, M. C.* Science 2007, 318, 783-787.
[ Abstract ]

08 Jan 2008, presented by Justin Cisar
Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin.
Chandrasekaran, A.; Srinivasan, A.; Raman, R.; Viswanathan, K.; Raguram, S.; Tumpey, T. M.; Sasisekharan, V.; Sasisekharan, R* Nat. Biotechnol. 2008, 26, 107-113.
[ Abstract ]