Christopher Stratton

Xu, H.; Sullivan, T. J.; Sekiguchi, J.; Kirikae, T.; Ojima, I.; Stratton, C. F.; Mao, W.; Rock, F. L.; Alley, M. R. K.; Johnson, F.; Walker, S. G.; Tonge, P. J.* “Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus.” Biochemistry 2008, 47, 4228-4236.
[ Abstract | PDF | Supporting Info ]

Bell, A. F.; Stratton, C. F.; Zhang, X.; Novichenok, P.; Jaye, A. A.; Nair, P. A.; Parikh, S.; Rawat, R.; Tonge, P. J.* “Evidence from Raman spectroscopy that InhA, the mycobacterial enoyl reductase, modulates the conformation of the NADH cofactor to promote catalysis.” J. Am. Chem. Soc. 2007, 129, 6425-6431.
[ Abstract | PDF ]

Rafi, S.; Novichenok, P.; Kolappan, S.; Zhang, X.; Stratton, C. F.; Rawat, R.; Kisker, C.*; Simmerling, C.*; Tonge, P. J.* “Structure of acyl carrier protein bound to FabI, the FASII enoyl reductase from Escherichia coli.” J. Biol. Chem. 2006, 281, 39285-39293.
[ Abstract | PDF ]

Sullivan, T. J.; Truglio, J. J.; Boyne, M. E.; Novichenok, P.; Zhang, X.; Stratton, C. F.; Li, H.-J.; Kaur, T.; Amin, A.; Johnson, F.; Slayden, R. A.*; Kisker, C.*; Tonge, P. J.* “High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis.” ACS Chem. Biol. 2006, 1, 43-53.
[ Abstract | PDF | Supporting Info ]