Christopher Stratton, PhD
Graduate Student (2007 - 2012)
E-mail:
cfstratton@gmail.com Postdoctoral Fellow with Prof. Vern L. Schramm
Department of Biochemistry
Albert Einstein College of Medicine
PhD, Weill Cornell Medical College, 2012
Tri-Institutional Training Program in Chemical Biology
BS, SUNY Stony Brook, 2006
Thesis: The Diversity-Oriented Synthesis of Macrocycles using Oxidative Ring Expansion Reactions, June 27, 2012
Publications
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A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion.
Kopp, F.; Stratton, C. F.; Akella, L. B.; Tan, D. S.* Nat. Chem. Biol. 2012, 8, 358–365.
[ Abstract | PubMed | PMC ]
(Highlighted in SciBX ) -
Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus.
Xu, H.; Sullivan, T. J.; Sekiguchi, J.; Kirikae, T.; Ojima, I.; Stratton, C. F.; Mao, W.; Rock, F. L.; Alley, M. R. K.; Johnson, F.; Walker, S. G.; Tonge, P. J.* Biochemistry 2008, 47, 4228–4236.
[ Abstract | PubMed ] -
Evidence from Raman spectroscopy that InhA, the mycobacterial enoyl reductase, modulates the conformation of the NADH cofactor to promote catalysis.
Bell, A. F.; Stratton, C. F.; Zhang, X.; Novichenok, P.; Jaye, A. A.; Nair, P. A.; Parikh, S.; Rawat, R.; Tonge, P. J.* J. Am. Chem. Soc. 2007, 129, 6425–6431.
[ Abstract | PubMed ] -
Structure of acyl carrier protein bound to FabI, the FASII enoyl reductase from Escherichia coli.
Rafi, S.; Novichenok, P.; Kolappan, S.; Zhang, X.; Stratton, C. F.; Rawat, R.; Kisker, C.*; Simmerling, C.*; Tonge, P. J.* J. Biol. Chem. 2006, 281, 39285–39293.
[ Abstract | PubMed ] -
High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis.
Sullivan, T. J.; Truglio, J. J.; Boyne, M. E.; Novichenok, P.; Zhang, X.; Stratton, C. F.; Li, H.-J.; Kaur, T.; Amin, A.; Johnson, F.; Slayden, R. A.*; Kisker, C.*; Tonge, P. J.* ACS Chem. Biol. 2006, 1, 43–53.
[ Abstract | PubMed ]
