Senior Research Scientist, 2010–present
Organix, Inc.
Woburn, MA

Senior Research Scientist, 2009–2010
Anichem, Inc.
North Brunswick, NJ

PhD, CUNY-Queens, 2005

MPhil, CUNY-Queens, 2002

MS, Peking University, 1999

BS, Peking University, 1996

1 Patent Application

15) Olsen, S. K.; Capili. A. D.; Lu, X.; Tan, D. S.*; Lima, C. D.* “Active site remodelling accompanies thioester bond formation in the SUMO E1.” Nature 2010, 463, 906-912.

[ Abstract | PDF | Supporting Info | PMC ]
• Highlighted in Nature, Chem. Eng. News, Nat. Rev. Mol. Cell Biol., Nat. Chem. Biol., Structure, ACS Chem. Biol., and Faculty of 1000 Biology
14) Lu, X.; Olsen, S. K.; Capili, A. D.; Cisar, J. S.; Lima, C. D.*; Tan, D. S.* “Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.” J. Am. Chem. Soc. 2010, 132, 1748-1749.

[ Abstract | PDF | Supporting Info | PMC ]
• Highlighted in Chem. Eng. News, Nat. Rev. Mol. Cell Biol., Nat. Chem. Biol., ACS Chem. Biol., and Faculty of 1000 Biology
13) Lu, X.; Zhang, H.; Tonge, P. J.*; Tan, D. S.* “Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis.” Bioorg. Med. Chem. Lett. 2008, 18, 5963-5966.

[ Abstract | PDF | Supporting Info | PMC ]
12) Ferreras, J. A.; Stirrett, K. L.; Lu, X.; Ryu, J.-S.; Soll, C. E.; Tan, D. S.; Quadri, L. E. N.* “Mycobacterial phenolic glycolipid virulence factor biosynthesis: Mechanism and small-molecule inhibition of polyketide chain initiation.” Chem. Biol. 2008, 15, 51-61.

[ Abstract | PDF | Supporting Info | PMC ]
• Highlighted in Chem. Biol.
11) Lu, X.; Song, L.; Metelitsa, L. S.; Bittman, R.* “Synthesis and evaluation of an α-C-galactosylceramide analogue that induces Th1-biased responses in human natural killer T cells.” ChemBioChem 2006, 7, 1750-1756.

[ Abstract | PDF ]
10) Byun, H.-S.; Lu, X., Bittman, R.* “Stereoselective total synthesis of serine palmitoyl-CoA transferase inhibitors.” Synthesis 2006, 2447-2474.

[ Abstract | PDF ]
9) Lu, X.; Bittman, R.* “Enantioselective synthesis of the phosphate esters of the immunosuppressive lipid FTY720.” Tetrahedron Lett. 2006, 47, 825-827.

[ Abstract | PDF ]
8) Lu, X.; Bittman, R.* “Synthesis of a photoactivatable (2S,3R)-sphingosylphosphorylcholine analogue.” J. Org. Chem. 2005, 70, 4746-4750.

[ Abstract | PDF | Supporting Info ]
7) Lu, X.; Bittman, R.* “An efficient synthesis of D-ribo- and L-lyxo-phytosphingosine from D-tartaric acid.” Tetrahedron Lett. 2005, 46, 3165-3168.

[ Abstract | PDF ]
6) Lu, X.; Arthur, G.; Bittman, R.* “Synthesis of a novel ceramide analogue via Tebbe methylenation and evaluation of its antiproliferative activity.” Org. Lett. 2005, 7, 1645-1648.

[ Abstract | PDF | Supporting Info ]
5) Lu, X.; Bittman, R.* “Efficient and versatile synthesis of (2S,3R)-sphingosine and its 2-azido-3-O-benzylsphingosine analogue.” Tetrahedron Lett. 2005, 46, 1873-1875.

[ Abstract | PDF ]
4) Lu, X.; Byun, H.-S.; Bittman, R.* “Synthesis of L-lyxo-phytosphingosine and its 1-phosphonate analogue using a threitol acetal synthon.” J. Org. Chem. 2004, 69, 5433-5438.

[ Abstract | PDF | Supporting Info ]
3) Lu, X.; Cseh, S.; Byun, H.-S.; Tigyi, G.; Bittman, R.* “Total synthesis of two photoactivatable analoguse of the growth-factor-like mediator sphingosine 1-phosphage: Differential interaction with protein targets.” J. Org. Chem. 2003, 68, 7046-7050.

[ Abstract | PDF | Supporting Info ]
2) Liu, J.; Zeng, G.; Lu, X.* “Inter-comparison of 90Sr and 137Cs contents in biological samples and natural U in soil samples.” Fushe Fanghu 2001, 21, 34-39.
1) Lu, X.; Zhai, M.; Li, J.; Ha, H.* “Radiation preparation and thermo-response swelling of interpenetrating polymer network hydrogel composed of PNIPAAm and PMMA.” Radiation Phys. Chem. 2000, 57, 477-480.

[ Abstract ]
06/01/2010 Collaborative Team Advances the Understanding of an Important Activity Inside Cells (MSKCC Center News)

A collaborative team of researchers from Memorial Sloan-Kettering has determined the mechanism for a biological process that plays a key role in regulating cellular behavior. The process — and the enzymes that control it — has been studied for 30 years, but until now it was a mystery to researchers in the field how this complex reaction takes place. [Full text]
02/22/2010 Activation of Protein Tags: Enzymology: To prepare biological labels for attachment, E1 enzymes dramatically remodel themselves (Chemical & Engineering News)

In a tour de force chemical, structural, and mechanistic study that took five years, researchers have solved a long-standing mystery in a Nobel Prize-winning field of research-they have shown how E1 enzymes activate ubiquitin and related proteins to tag other proteins. [Full text]
02/18/2010 Structural Biology: Transformative Encounters (Nature)

Researchers have met the challenge of capturing transient states of the SUMO E1 activating enzyme. Their pictures show radically different crystal structures for two of the steps in this enzyme’s activity. [Full text]
12/27/2007 New Drug Targets May Fight Tuberculosis and Other Bacterial Infections in Novel Way (Weill Cornell News)

Research into “virulence factors” expands war against infectious disease beyond antibiotics, Weill Cornell researchers say. [Full text]
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