Diversity-Oriented Synthesis and Rational Drug Design for Chemical Biology and Drug Discovery Research in the Tan Lab
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Read up on the latest publications in diversity-oriented synthesis, rational drug design, and chemical biology research from the Tan Lab!PubMed Central (PMC) versions of articles are available free of charge. Access to PDF versions of articles requires online subscription.
| 32) | Wurst, J. M.; Liu, G.; Tan, D. S.* “Hydrogen-bonding catalysis and inhibition by simple solvents in the stereoselective kinetic epoxide-opening spirocyclization of glycal epoxides to form spiroketals.” J. Am. Chem. Soc. 2011, 133, 7916-7925. [ Abstract | PDF | Supporting Info ] |
| 31) | Moura-Letts, G.; DiBlasi, C. M.; Bauer, R. A.; Tan, D. S.* “Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library.” Proc. Natl. Acad. Sci. USA 2011, 108, 6745-6750. [ Abstract | PDF | Supporting Info ] |
| 30) | Bauer, R. A.; DiBlasi, C. M.; Tan, D. S.* “The tert-butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis.” Org. Lett. 2010, 12, 2084-2087. [ Abstract | PDF | Supporting Info | PMC ] |
| 29) | Bauer, R. A.; Wurst, J. M.; Tan, D. S.* “Expanding the range of ‘druggable’ targets with natural product-based libraries: An academic perspective.” Curr. Opin. Chem. Biol. 2010, 14, 308-314. [ Abstract | PDF | Supporting Info ] |
| 28) | Olsen, S. K.; Capili. A. D.; Lu, X.; Tan, D. S.*; Lima, C. D.* “Active site remodelling accompanies thioester bond formation in the SUMO E1.” Nature 2010, 463, 906-912. [ Abstract | PDF | Supporting Info | PMC ] |
| • | Highlighted in Nature, Chem. Eng. News, Nat. Rev. Mol. Cell Biol., Nat. Chem. Biol., Structure, ACS Chem. Biol., and Faculty of 1000 Biology |
| 27) | Lu, X.; Olsen, S. K.; Capili, A. D.; Cisar, J. S.; Lima, C. D.*; Tan, D. S.* “Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.” J. Am. Chem. Soc. 2010, 132, 1748-1749. [ Abstract | PDF | Supporting Info | PMC ] |
| • | Highlighted in Chem. Eng. News, Nat. Rev. Mol. Cell Biol., Nat. Chem. Biol., ACS Chem. Biol., and Faculty of 1000 Biology |
| 26) | Liu, G.; Wurst, J. M.; Tan, D. S.* “Stereoselective synthesis of benzannulated spiroketals: Influence of the aromatic ring on reactivity and conformation.” Org. Lett. 2009, 11, 3670-3673. [ Abstract | PDF | Supporting Info | PMC ] |
| 25) | Lu, X.; Zhang, H.; Tonge, P. J.*; Tan, D. S.* “Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis.” Bioorg. Med. Chem. Lett. 2008, 18, 5963-5966. [ Abstract | PDF | Supporting Info | PMC ] |
| 24) | Cisar, J. S.; Tan, D. S.* “Small molecule inhibition of microbial natural product biosynthesis - An emerging antibiotic strategy.” Chem. Soc. Rev. 2008, 37, 1320-1329. [ Abstract | PDF | PMC ] |
| 23) | Ferreras, J. A.; Stirrett, K. L.; Lu, X.; Ryu, J.-S.; Soll, C. E.; Tan, D. S.; Quadri, L. E. N.* “Mycobacterial phenolic glycolipid virulence factor biosynthesis: Mechanism and small-molecule inhibition of polyketide chain initiation.” Chem. Biol. 2008, 15, 51-61. [ Abstract | PDF | Supporting Info | PMC ] |
| • | Highlighted in Chem. Biol. |
| 22) | Cisar, J. S.; Ferreras, J. A.; Soni, R. K.; Quadri, L. E. N.*; Tan, D. S.* “Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules.” J. Am. Chem. Soc. 2007, 129, 7752-7753. [ Abstract | PDF | Supporting Info | PMC ] |
| • | Highlighted in Faculty of 1000 Biology |
| 21) | Shang, S.; Iwadare, H.; Macks, D. E.; Ambrosini, L. M.; Tan, D. S.* “A unified synthetic approach to polyketides having both skeletal and stereochemical diversity.” Org. Lett. 2007, 9, 1895-1898. [ Abstract | PDF | Supporting Info | PMC ] |
| 20) | Moilanen, S. B.; Potuzak, J. S.; Tan, D. S.* “Stereocontrolled synthesis of spiroketals via Ti(Oi-Pr)4-mediated kinetic spirocyclization of glycal epoxides with retention of configuration.” J. Am. Chem. Soc. 2006, 128, 1792-1793. [ Abstract | PDF | Supporting Info | PMC ] |
| • | Highlighted in Nature |
| 19) | Potuzak, J. S.; Moilanen, S. B.; Tan, D. S.* “Stereocontrolled synthesis of spiroketals via a remarkable methanol-induced kinetic spirocyclization reaction.” J. Am. Chem. Soc. 2005, 127, 13796-13797. [ Abstract | PDF | Supporting Info ] |
| 18) | Tan, D. S.* “Diversity-oriented synthesis: Exploring the intersections between chemistry and biology.” Nature Chem. Biol. 2005, 1, 74-84. [ Abstract | PDF ] |
| • | Highlighted in Nat. Chem. Biol. |
| 17) | Ferreras, J. A.; Ryu, J.-S.; Di Lello, F.; Tan, D. S.*, Quadri, L. E. N.* “Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis.” Nature Chem. Biol. 2005, 1, 29-32. [ Abstract | PDF | Supporting Info ] |
| • | Highlighted in Nature, Nat. Chem. Biol., Chem. Eng. News, and Mercosur Económico (PDF) |
| 16) | Shang, S.; Tan, D. S.* “Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries.” Curr. Opin. Chem. Biol. 2005, 9, 248-258. [ Abstract | PDF ] |
| 15) | DiBlasi, C. M.; Macks, D. E.; Tan, D. S.* “An acid-stable tert-butyldiarylsilyl (TBDAS) linker for solid-phase organic synthesis.” Org. Lett. 2005, 7, 1777-1780. [ Abstract | PDF | Supporting Info ] |
| • | Highlighted in Lett. Org. Chem. (PDF) |
| 14) | Moilanen, S. B.; Tan, D. S.* “Enantioselective synthesis of erythro-4-deoxyglycals as scaffolds for target- and diversity-oriented synthesis: New insights into glycal reactivity.” Org. Biomol. Chem. 2005, 3, 798-803. [ Abstract | PDF | Supporting Info ] |
| 13) | Tan, D. S.* “Current progress in natural product-like libraries for discovery screening.” Comb. Chem. High-Throughput Screen. 2004, 7, 631-643. [ Abstract ] |
| 12) | Potuzak, J. S.; Tan, D. S.* “Synthesis of C1-alkyl and C1-acylglycals from glycals using a B-alkyl Suzuki–Miyaura cross coupling approach.” Tetrahedron Lett. 2004, 45, 1797-1801. [ Abstract | PDF | Supporting Info ] |
