Douglas A. Levine, MD, FACOG, FACS

The Gynecology Research Laboratory is a disease-focused laboratory investigating the genomic basis of ovarian and uterine cancers for the purpose of improving prevention and control of these diseases. We are particularly interested in advancing opportunities for individualized therapy for women with gynecologic malignancies through integrated and functional genomic approaches. Our goal is to create new knowledge that will translate into clinical utility to improve the standard of care for ovarian and endometrial carcinoma. We have long studied the translational and biologic aspects of BRCA dysfunction as related to risk of disease and homologous recombination deficiency. We use an extensive biospecimen resource housed in the laboratory to study human tumors and validate discoveries with additional in vitro experimentation.

Publications

Verhaak RG, Tamayo P, Yang JY, Hubbard D, Zhang H, Creighton CJ, Fereday S, Lawrence M, Carter SL, Mermel CH, Kostic AD, Etemadmoghadam D, Saksena G, Cibulskis K, Duraisamy S, Levanon K, Sougnez C, Tsherniak A, Gomez S, Onofrio R, Gabriel S, Chin L, Zhang N, Spellman PT, Zhang Y, Akbani R, Hoadley KA, Kahn A, Köbel M, Huntsman D, Soslow RA, Defazio A, Birrer MJ, Gray JW, Weinstein JN, Bowtell DD, Drapkin R, Mesirov JP, Getz G, Levine DA, Meyerson M; Cancer Genome Atlas Research Network. Prognostically relevant gene signatures of high-grade serous ovarian carcinoma. J Clin Invest. 2013 Jan 2;123(1):517-25. doi: 10.1172/JCI65833. Epub 2012 Dec 21.

Soslow RA, Wethington SL, Cesari M, Chiappetta D, Olvera N, Shia J, Levine DA. Clinicopathologic analysis of matched primary and recurrent endometrial carcinoma. Am J Surg Pathol. 2012 Dec;36(12):1771-81. doi: 10.1097/PAS.0b013e318273591a.

Barlin JN, Jelinic P, Olvera N, Bogomolniy F, Bisogna M, Dao F, Barakat RR, Chi DS, Levine DA. Validated gene targets associated with curatively treated advanced serous ovarian carcinoma. Gynecol Oncol. 2013 Mar;128(3):512-7. doi: 10.1016/j.ygyno.2012.11.018. Epub 2012 Nov 17.

Hanrahan AJ, Schultz N, Westfal ML, Sakr RA, Giri DD, Scarperi S, Janakiraman M, Olvera N, Stevens EV, She QB, Aghajanian C, King TA, Stanchina Ed, Spriggs DR, Heguy A, Taylor BS, Sander C, Rosen N, Levine DA, Solit DB. Genomic complexity and AKT dependence in serous ovarian cancer. Cancer Discov. 2012 Jan;2(1):56-67. doi: 10.1158/2159-8290.CD-11-0170.

Soslow RA, Han G, Park KJ, Garg K, Olvera N, Spriggs DR, Kauff ND, Levine DA. Morphologic patterns associated with BRCA1 and BRCA2 genotype in ovarian carcinoma. Mod Pathol. 2012 Apr;25(4):625-36. doi: 10.1038/modpathol.2011.183. Epub 2011 Dec 23.

Office phone:
212-639-7335
View Douglas A. Levine’s physician profile.
Selected Achievements

Co-Chair of TCGA Ovarian and Endometrial Working Groups, Foundation for Women’s Cancer Excellence in Ovarian Cancer Research Prize (2013)

Course Director, American Association for Cancer Research Special Conference on Ovarian Cancer Research (2103)

Scientific Advisory Committee Member, Ovarian Cancer Research Fund (2010)