Figure 1 Figure 1 A highly simplified model of Notch signaling. Neur and Mib are E3 ubiquitin ligases that activate DSL ligands. Interaction between the extracellular domains of DSL and Notch triggers cleavage and release of the Notch intracellular domain (Nintra).
Figure 2 Figure 2 Loss of Notch signaling results in ectopic sensory organs (due to failure of inhibitory signaling during neural restriction), and in loss of wing tissue (due to failure of inductive signaling during wing margin specification).
Figure 3 Figure 3 The ubiquitin ligase D-mib induces endocytosis of Delta (in red), a prerequisite for activation of Delta signaling activity.