Our laboratory investigates innate and adaptive immune responses to infection by pathogenic organisms. We have established several model systems to characterize innate immunity and antigen specific T cell responses. We use the intracellular bacterium Listeria monocytogenes to investigate early defense against bacterial infection.

Publications

van Heijst JW, Ceberio I, Lipuma LB, Samilo DW, Wasilewski GD, Gonzales AM, Nieves JL, van den Brink MR, Perales MA, Pamer EG. Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation. Nat Med. 2013 Mar;19(3):372-7. doi: 10.1038/nm.3100. Epub 2013 Feb 24.

Ubeda C, Bucci V, Caballero S, Djukovic A, Toussaint NC, Equinda M, Lipuma L, Ling L, Gobourne A, No D, Taur Y, Jenq RR, van den Brink MR, Xavier JB, Pamer EG. Intestinal microbiota containing Barnesiella species cures vancomycin-resistant Enterococcus faecium colonization. Infect Immun. 2013 Mar;81(3):965-73. doi: 10.1128/IAI.01197-12. Epub 2013 Jan 14.

Ubeda C, Lipuma L, Gobourne A, Viale A, Leiner I, Equinda M, Khanin R, Pamer EG. Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice. J Exp Med. 2012 Jul 30;209(8):1445-56. doi: 10.1084/jem.20120504. Epub 2012 Jul 23.

Taur Y, Xavier JB, Lipuma L, Ubeda C, Goldberg J, Gobourne A, Lee YJ, Dubin KA, Socci ND, Viale A, Perales MA, Jenq RR, van den Brink MR, Pamer EG.Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin Infect Dis. 2012 Oct;55(7):905-14. doi: 10.1093/cid/cis580. Epub 2012 Jun 20.

Kinnebrew MA, Buffie CG, Diehl GE, Zenewicz LA, Leiner I, Hohl TM, Flavell RA, Littman DR, Pamer EG. Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity. 2012 Feb 24;36(2):276-87. doi: 10.1016/j.immuni.2011.12.011. Epub 2012 Feb 2.

Office phone:
646-888-2679
Office fax:
646-422-0502
Laboratory phone:
646-888-2361
View Eric G. Pamer’s physician profile.
Selected Achievements

Member, Association of American Physicians (2011)

Fellow, Infectious Diseases Society of America (2010)

Member, American Society for Clinical Investigation (1998)

Pew Scholar in the Biomedical Sciences, Pew Charitable Trust (1994)