Research in my laboratory is aimed at developing pharmacologic tools that selectively target the pathogenic role of molecular chaperones; understanding how molecular chaperones effect their specialized roles in pathogenic cells; and creating a map of disease-specific molecular alterations, using selective chaperone modulators. Our laboratory operates at the interface of chemistry, biology, and medicine. Its research is focused on generating pharmacological and methodological tools for understanding the clinical relevance of modulating the function or expression of proteins involved in transformation (oncogenic and neurodegenerative) and in using these tools for the translation of agents into therapeutics. My group is interdisciplinary and functions with the understanding that we are able to discover and synthesize pharmacological agents, determine their mechanisms of action and significance in disease treatment, and ultimately develop rational strategies for their use in clinic.