Chemical Biology Approach to Investigate Regulation of Pathogenic Stress by the Molecular Chaperone Machinery

Molecular chaperones are ubiquitously expressed proteins with wide-ranging functions in the folding and cellular translocation of a variety of proteins. Whereas these house-keeping functions are well recognized and have been the subject of intense investigation, it is now becoming clearer that chaperones are also co-opted in pathogenic cells to carry out disease-specific specialized roles. It is now believed that in pathogenic systems, chaperones abet transformation and allow for the blossoming of the disease phenotype.

Development of Chemical Tools and Assays

Chemical tools address the biology of proteins in the cellular environment where the protein is limiting but not absent and can probe and manipulate a protein’s function in a controlled manner.