Grégoire Altan-Bonnet: Publications

Tkach KE, Barik D, Voisinne G, Malandro N, Hathorn MM, Cotari JW, Vogel R, Merghoub T, Wolchok J, Krichevsky O, Altan-Bonnet G. “T cells translate individual, quantal activation into collective, analog cytokin responses via time-integrated feedbacks” Elife (Cambridge), 2014 Apr 9

Jesse W. Cotari, Guillaume Voisinne, Orly Even-Dar, Volkan Karabacak & Grégoire Altan-Bonnet “Cell-to-cell variability analysis of signal transduction reveals switch in cytokine sensitivity for T lymphocytes” Science Signaling, (2013) in press

Paul François, Guillaume Voisinne, Eric D Siggia, Grégoire Altan-Bonnet & Massimo Vergassola A phenotypic model for early T-cell activation displaying sensitivity, specificity and antagonism” Proceedings of the National Academy of Sciences USA, (2013) in press

Karen Tkach & Grégoire Altan-Bonnet “T cell responses to antigen: hasty proposals resolved through long engagements” Current Opinion in Immunology (2012) 25:1-6

Thomas Höfer, Oleg Krichevsky & Grégoire Altan-Bonnet “Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses” Frontiers in Immunology, (2012) 3:268

Grégoire Altan-Bonnet & Fred Russel Kramer “Nucleic acid hybridization: Robust sequence discrimination” Nature Chemistry, (2012) 4: 155-157

Emanuela Romano, Jesse W Cotari, Rosa Barreira da Silva, Brian C Betts, David J Chung, Francesca Avogadri, Mitsu J Fink, Erin T St Angelo, Babak Mehrara, Glenn Heller, Christian Münz, Gregoire Altan-Bonnet, James W Young Human Langerhans cells use an IL-15R-α/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1Blood, (2012) 119[22]: 5182-5190

Rachel A Gottschalk, Matthew M Hathorn, Hélène  Beuneu, Emily Corse, Michale L Dustin, Grégoire Altan-Bonnet, James P Allison “Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses” Proceedings of the National Academy of Sciences, (2012)

Thierry Emonet & Grégoire Altan-Bonnet “Systems Immunology: a primer for Biophysicists” Section: “Mathematical Modeling of Complex Systems: from genes and molecules to organs and organisms: immune system” Chapter 9:26 for “Comprehensive Biophysics” (Edited by Edward Egelman) (2012 -in press)

Emily J Quann, X Liu, Grégoire Altan-Bonnet, Morgan Huse “A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells” Nature Immunology 12 (7), 647-654 (2011)

Ofer Feinerman*, Garrit Jentsch*, Karen Tkach, Jesse W. Coward, Matthew Hathorn, Michael W. Sneddon, Thierry Emonet, Kendall A. Smith & Grégoire Altan-Bonnet “Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response” Molecular Systems Biology 6:437 (2010)

Jesse Coward, Ronald N. Germain, and Grégoire Altan-Bonnet “Perspectives for computer modeling in the study of T cell activation” Cold Spring Harb Perspect Biol. 2010 Jun 1;2(6):a005538.

Robert J Prill, Daniel Marbach, Julio Saez-Rodriguez, Peter K Sorger, Leonidas G Alexopoulos, Xiawei Xue, Neil D Clarke, Grégoire Altan-Bonnet , and Gustavo Stolovitzky. “Towards a rigorous assessment of systems biology models: the DREAM3 challenges.” PLoS One, 5(2):e9202, (2010)

Nihal Altan-Bonnet & Grégoire Altan-Bonnet “Fluorescence Correlation Spectroscopy in living cells: a practical approach”Current Protocols in Cell Biology (2009) Chapter 4:Unit 4.24.

Gabrielle A. Rizzuto, Taha Merghoub, Daniel Hirschhorn-Cymerman, Cailian Liu, Alexander M Lesokhin, Diana Sahawneh, Hong Zhong, Katherine S. Panageas, Miguel-Angel Perales, Grégoire Altan-Bonnet, Jedd D. Wolchok*, Alan N. Houghton* “Self-antigen specific CD8+ T cell precursor frequency determines the quality of the anti-tumor immune response” Journal of Experimental Medicine (2009) 10.1084/jem.20081382

Ofer Feinerman*, Joël Veiga*, Jeffrey R. Dorfman, Ronald N. Germain & Grégoire Altan-Bonnet “Variability and robustness in T cell activation from regulated heterogeneity in protein levels” Science (2008) 321(5892):1081-4. PMID: 18719282

Sydney X. Lu, Onder Alpdogan, Melanie Chow, David Suh, Vanessa M. Hubbard, Jhoanne Bautista, Adam A. Kochman, Johannes L. Zakrzewski, Theo D. Kim, O. Marsinay Smith, Jeremy Grubin, Andrew Chow, Neel Patel, Christopher King, Grégoire Altan-Bonnet, Marcel R.M. van den Brink “The Signaling Profile of Alloactivated T cells During Acute Graft-Versus-Host-Disease” Blood (2008) 112(13): 5254-5258

Ofer Feinerman, Ronald N. Germain & Grégoire Altan-Bonnet“Quantitative challenges to understanding T cell ligand discrimination”Molecular Immunology (2008) 45(3): 619-3

Flora Castellino*, Alex Y. Huang*, Grégoire Altan-Bonnet, Sabine Stoll, Clemens Scheinecker and Ronald N. Germain “Chemokines enhance immunity by guiding naive CD8 T cells to sites of CD4 T cell–dendritic cell interaction” Nature 440, 890-895 (2006) [DOI:10.1038/nature04651]

Grégoire Altan-Bonnet and Ronald N. Germain “Modeling T cell antigen discrimination based on feedback control of digital ERK response” PLoS biology (2005) Volume 3, Issue 11, e356 [DOI: 10.1371/journal.pbio.0030356]