Computational biologist Grégoire Altan-Bonnet focuses on probing and testing the integration of cellular activation that makes up the immune response.

Publications

Cotari JW, Voisinne G, Dar OE, Karabacak V, Altan-Bonnet G. Cell-to-cell variability analysis dissects the plasticity of signaling of common γ chain cytokines in T cells. Sci Signal. 2013 Mar 12;6(266):ra17. doi: 10.1126/scisignal.2003240. [PMID: 23482665]

François P, Voisinne G, Siggia ED, Altan-Bonnet G, Vergassola M. Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E888-97. doi: 10.1073/pnas.1300752110. Epub 2013 Feb 19. [PMID: 23431198]

Feinerman O, Jentsch G, Tkach KE, Coward JW, Hathorn MM, Sneddon MW, Emonet T, Smith KA, Altan-Bonnet G. Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response. Mol Syst Biol. 2010 Nov 30;6:437. doi: 10.1038/msb.2010.90. [PMID: 21119631]

Feinerman O, Veiga J, Dorfman JR, Germain RN, Altan-Bonnet G. Variability and robustness in T cell activation from regulated heterogeneity in protein levels. Science. 2008 Aug 22;321(5892):1081-4. doi: 10.1126/science.1158013. [PMID: 18719282]

Tkach KE, Barik D, Voisinne G, Malandro N, Hathorn MM, Cotari JW, Vogel R, Merghoub T, Wolchok J, Krichevsky O, Altan-Bonnet G. Elife (Cambridge). 2014 Apr 9;3:e01944. doi: 10.7554/eLife.01944.

Altan-Bonnet G, Germain RN. Modeling T cell antigen discrimination based on feedback control of digital ERK responses. PLoS Biol. 2005 Nov;3(11):e356. Epub 2005 Oct 25. [PMID: 16231973]

Office phone:
646-888-2619
Laboratory phone:
646-888-2399
Selected Achievements

Development of methods to analyze cell-to-cell variability within isogenic population of cells

Quantitative analysis of the role of cytokine competition as a key mediator of the balance between tolerance and response among T lymphocytes

Development of a fully integrated computational/experimental approach to study the immune response