Bergman PJ, McKnight J, Novosad A, Charney S, Farrelly J, Craft D, Wulderk M, Jeffers Y, Sadelain M, Hohenhaus A, Segal N, Gregor P, Engelhorn M, Riviere I, Houghton AN, Wolchok JD. Long term survival of dogs with advanced malignant melanoma following DNA vaccination with xenogeneic human tyrosinase: A phase I trial. Clin Cancer Res, 2003;9:1284-90.

Wolchok JD, Chapman PB. How can we tell when cancer vaccines vaccinate? J Clin Oncol 2003:21:586-87.

Hawkins WG, Trcka J, Segal N, Blachere NE, Gold JS, Moroi Y, Browne WB, Lewis JJ, Wolchok JD, Houghton AN. The role of lipopolysaccharide in T-cell responses following DNA vaccination. Vaccine 2003: 21:1548-53.

Perales MA, Fantuzzi G, Goldberg SM, Turk MJ, Mortazavi F, Busam K, Houghton AN, Wolchok JD. GM-CSF DNA induces specific patterns of cytokines and chemokines in the skin: implications for DNA vaccines. Cytokines, Cell Mol Ther, 2003;7: 125-33.

Gold JS, Ferrone CR, Guevara-Patino JA, Hawkins WG, Dyall R, Engelhorn ME, Wolchok JD, Lewis JJ, Houghton AN. A single heteroclitic epitope determines cancer immunity after xenogeneic DNA immunization against a tumor differentiation antigen. J Immunol 2003;170:5188-94.

Ramirez-Montagut T, Turk MJ, Wolchok JD, Guevara-Patino JA, Houghton AN. Immunity to melanoma: unraveling the relation to tumor immunity and autoimmunity. Oncogene 2003;22:3180-87.

Wolchok JD, Gregor PD, Nordquist LT, Slovin SF, Scher Hl. DNA vaccines: an active immunization strategy for prostate cancer. Semin Oncol 2003;30:659-66.

Ragupathi G, Livingston PO, Hood C, Gathuru J, Krown SE, Chapman PB, Wolchok JD, Williams LJ, Oldfield RC, Hwu WJ. Consistent antibody response against ganglioside GD2 induced in patients with melanoma by a GD2 lactone-keyhole limpet hemocyanin conjugate vaccine plus immunological adjuvant QS-21. Clin Cancer Res 2003;9:5214-20.

Guevara-Patino JA, Turk MJ, Wolchok JD, Houghton AN. Immunity to cancer through immune recognition of altered self: studies with melanoma. Adv. Cancer Res. 2003;90:157-77.

Su YB, Sohn S, Krown SE, Livingston PO, Wolchok JD, Quinn C, Williams L, Foster T, Sepkowitz KA, Chapman PB. Selective CD4 Lymphopenia in melanoma patients treated with temozolomide: A toxicity with therapeutic implications. J Clin Oncol 2004;22:610-16.

Gregor PD, Wolchok JD, Ferrone CR, Buchinsky H, Gurvara-Patino JA, Perales MA, Mortazavi F, Bacich D, Heston W, Latouch JB, Sadelain M, Allison JP, Scher HI, Houghton AN. CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems. Vaccine, 2004;22:1700-08.

Srinivasan R, Wolchok JD. Tumor antigens for cancer immunotherapy: therapeutic potential of xenogeneic DNA vaccines. J Transl Med 2004; 2:12.

Perales ML, Wolchok JD. CD4 help and tumor immunity: beyond the activation of cytotoxic T lymphocytes. Ann Surg Oncol 2004;11:881-2.

Segal NH, Blachere NE, Shiu HY, Leejee S, Antonescu C, Lewis JJ, Wolchok JD, Houghton AN. Antigens recognized by autologous antibodies of patients with soft tissue sarcoma. Cancer Immun. 2005;5:4.

Palomba ML, Roberts WK, Dao T, Manukian G, Guevara-Patino JA, Wolchok JD, Scheinberg DA, Houghton AN. CD8+ T-cell-dependent immunity following xenogeneic DNA immunization against CD20 in a tumor challenge model of B-cell lymphoma. Clin Cancer Res. 2005;11:370-9.

Gregor PD, Wolchok JD, Turaga V, Latouche JB, Sadelain M, Bacich D, Heston WD, Houghton AN, Scher HI. Induction of autoantibodies to syngeneic prostate-specific membrane antigen by xenogeneic vaccination. Int J Cancer. 2005;116:415-21.

Goldberg SM, Bartido SM, Gardner JP, Guevara-Patino JA, Montgomery SC, Perales MA, Maughan MF, Dempsey J, Donovan GP, Olson WC, Houghton AN, Wolchok JD. Comparison of two cancer vaccines targeting tyrosinase: plasmid DNA and recombinant alphavirus replicon particles. Clin Cancer Res. 2005;11:8114-21.

Cohen AD, Wolchok JD. DNA vaccines for melanoma. Cancer Chemother Biol Response Modif 2005; 22:761-8.

Goldberg SM, Bartico SM, Gardner JP, Guevara-Patino JA, Montgomery SC, Perales MA, Maughan MF, Dempsey J, Donovan GP, Olson WC, Houghton AN, Wolchok JD. Comparison of two cancer vaccines targeting tyrosinase: plasmid DNA and recombinant alphavirus replicon particles. Clin Cancer Res 2005;11:8114-21.

Cohen AD, Diab A, Perales M-A, Wolchok JD, Rizzuto G, Merghoub T, Huggins D, Liu C, Turk MJ, Restifo NP, Sakaguchi S, Houghton AN. Agonist anti-GITR antibody enhances vaccine-induced CD8+ T-cell responses and tumor immunity. Cancer Res 2006;66:4904-12.

Guevara-Patiño JA, Engelhorn ME, Turk MJ, Liu C, Duan F, Rizzuto G, Cohen AD, Merghoub T, Wolchok JD, Houghton AN. Optimization of a self-antigen for presentation of multiple epitopes in cancer immunity. J Clin Invest 2006;116:1382-90.

Liao JC, Gregor P, Wolchok JD, Orlandi F, Craft D, Leung C, Houghton AN, Bergman PJ. Vaccination with human tyrosinase DNA induces antibody responses in dogs with advanced melanoma. Cancer Immun 2006;6:8.

Cohen AD, Diab A, Perales MA, Wolchok JD, Rizzuto G, Merghoub T, Huggins D, Liu C, Turk MJ, Restifo NP, Sakaguchi S, Houghton AN. Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity. Cancer Res 2006:66:4904-12.

Kaufman HL, Wolchok JD. Is tumor immunity the same thing as autoimmunity? Implications for cancer immunotherapy. J Clin Oncol 2006; 24:2230-2.

Uchi H, Stan R, Turk MJ, Engelhorn ME, Rizzuto GA, Goldberg SM, Wolchok JD, Houghton AN. Unraveling the complex relationship between cancer immunity and autoimmunity: lessons for melanoma and vitiligo. Adv. Immunol 2006;90:215-41.

Stan R, Wolchok JD, Cohen AD. DNA vaccines against cancer. Hematol Oncol Clin North Am 2006;20:613-36.

Perales MA, Diab A, Cohen AD, Huggins DW, Guevara-Patino JA, Hubbard VM, Engelhorn ME, Kochman AA, Eng JM, Mortazavi F, Alpdogan O, Terwey TH, Heller G. Wolchok JD, Houghton AN, van den Brink MR. DNA immunization against tissue-restricted antigens enhances tumor immunity after allogeneic hemopoietic stem cell transplantation. J Immunol 2006; 177:4159-67.

Ferrone CR, Perales MA, Goldberg SM, Somberg CJ, Hirschhorn-Cymerman D, Gregor PD, Turk MJ, Ramirez-Montagut T, Gold JS, Houghton AN, Wolchok JD. Ajuvanticity of plasmid DNA encoding cytokines fused to immunoglobulin Fc domains. Clin Cancer Res 2006; 12:5511-9.

Orlandi F, Venanzi FM, Concetti A, Yamauchi H, Tiwari S, Norton L, Wolchok JD, Houghton AN, Gregor PD. Antibody and CD8+ T Cell Responses against HER2/neu Required for Tumor Eradication after DNA Immunization with a Flt-3 Ligand Fusion Vaccine. Clinical Cancer Research. 2007:13:6195-203.

Wolchok JD, Yuan J, Houghton AH, Gallardo HF, Rasalan TS, Wang J, Zhang Y, Ranganathan R, Chapman PB, Krown SE, Livingston PO, Heywood M, Panageas KS, Terzulli SL, Perales MA. Safety and Immunogenicity of Tyrosinase DNA Vaccines in Patients with Melanoma. Mol Ther 2007;15):2044-2050.

Engelhorn M., Guevara-Patiño JA, Merghoub T, Liu C, Ferrone CR, Rizzut GA, Hirschhorn Cymerman D, Posnett DN, Houghton AN, Wolchok JD. Mechanisms of immunization against cancer using chimeric antigens. Mol Ther. 2008;16:773-781.

Perales MA, Yuan J, Powel S, Gallardo HF, Rasalan TS, Gonzalez C, Manukian G, Wang J, Zhang Y, Chapman PB, Krown SE, Livingston PO, Ejadi S, Panageas KS, Engelhorn ME, Terzulli SL, Houghton AN, Wolchok JD. Phase I/II Study of GM-CSF DNA as an Adjuvant for a Multipeptide Cancer Vaccine in Patients With Advanced Melanoma. Mol Ther. 2008; 16:2022-9.

Saenger YM, Li Y, Chiou KC, Chan B, Rizzuto G, Terzulli SL, Merghoub T, Houghton AN, and Wolchok JD. Improved tumor immunity using anti-tyrosinase related protein-1 mAb combined with DNA vaccines in murine melanoma. Cancer Res. 2008;68:9884-91.

Wolchok JD, Saenger Y. The mechanism of anti-CTLA-4 activity and the negative regulation of T-cell activation. Oncologist 2008 13 Suppl 4:2-9 (Review).

Yuan J, Gnjatic S, Li H, Powel S, Gallardo HF, Ritter E, Ku GY, Jungbluth Aa, Segal NH , Rasalan TS, Manukian G, Xu Y, Roman RA, Terzulli SL, Heywood M, Pogoriler E, Ritter G, Old LJ, Allison JP, Wolchok JD. CTLA-4 blockade enchances polyfunctional N-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit. Proc Nat Acad Sci 2008;105:20410-5.

Jenq RR, King CG, Volk C, Suh D, Smith OM, Rao UK, Yim NL, Holland AM, Lu SX, Zakrzewski JL, Goldberg GL, Diab A, Alpdogan O, Penack O, NA IK, Kappel LW, Wolchok JD, Houghton AN, Perales MA, van den Brink MR. Keratinocyte growth factor enchances DNA plasmid tumor vaccine responses after murine alloegeniec bone marrow transplantation. Blood 2009;113:1574-80.

Posnett DN, Engelhorn ME, Lin Y, Merghoub T, Duan F, Wolchok JD, Houghton AN. Development of effective vaccines for old mice in a tumor model. Vaccine 2009;27:1093-100.

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