During my PhD in Antonio Jacinto's lab, Portugal, I studied how signaling mediated by Rho1 GTPase is temporally and spatially controlled during morphogenesis via RhoGEFs and RhoGAPs, using epithelial cell invagination in the Drosophila embryo as a model system. In Jennifer Zallen's lab, at SKI, I have studied how a downstream target of Rho1 - Rho kinase - controls planar polarization of epithelial cells during convergence and extension movements in the Drosophila gastrula.
Education and Training
Postdoctoral Research Fellow
Memorial Sloan Kettering Institute, New York, Department of Developmental Biology.
Doctoral Research Scientist
Instituto Gulbenkian de Ciência, Oeiras, Portugal and Institute of Molecular Medicine, Lisbon, Portugal. PhD in Developmental Biology.
Mayo Clinic, Rochester, MN, Transplantation Biology Program.
Max Delbruck Center for Molecular Medicine, Berlin, Germany.
Graduation in Genetics and Microbiology by the Faculty of Sciences, University of Lisbon, Portugal.
Simoes S., Blankenship T., Weitz O., Farrell D., Tamada M., Fernandez-Gonzalez R. and Zallen J. (2010). Rho kinase directs Bazooka/Par3 planar polarity during Drosophila axis elongation. Developmental Cell 19(3), 377-88.
Fernandez-Gonzalez R., Simoes S., Röper J., Eaton S., and Zallen J. (2009). Myosin II dynamics are regulated by tension in intercalating cells. Developmental Cell 17 (5), 1-8.
Lovegrove, B., Simoes S., Rivas, M. L., Sotillos, S., Johnson, K., Knust, E., Jacinto, A. and Hombria, J. C. (2006). Coordinated control of cell adhesion, polarity, and cytoskeleton underlies hox-induced organogenesis in Drosophila. Current Biology 16, 2206-16.
Simoes S., Denholm, B., Azevedo, D., Sotillos, S., Martin, P., Skaer, H., Hombria, J. C. and Jacinto, A. (2006). Compartmentalisation of Rho regulators directs cell invagination during tissue morphogenesis. Development 133, 4257-67.
Moita, C., Simoes S., Moita L.F., Jacinto A., Fernandes P. (2005). The cadherin superfamily in Anopheles gambiae: a comparative study with Drosophila melanogaster. Computational Functional Genomics 6, 204-216.
Keshavarzi, S., Rietz, C., Simoes S., Shih, S., Platt, J. L., Wong, J., Wabl, M. and Cascalho, M. (2003). The possibility of B-cell-dependent T-cell development. Scandinavian Journal of Immunology 57, 446-52.
Parreira, L., Neves, H. and Simoes S. (2003). Notch and lymphopoiesis: a view from the microenvironment. Seminars in Immunology 15, 81-9.