Research Articles
Xi, Q., Wang, Z., Zaromytidou, A., Zhang, X. H.-F., Chow-Tsang, L.F., Liu, J.X., Kim, H., Manova-Todorova, K., Kaartinen, V., Studer, L., Mark, W., Patel, D.J. and Massagué, J. A poised chromatin platform for TGF-b access to master regulators. Cell 147, 1511-1524 (2011).
Chen, Q., Zhang, X.H.-F., and Massagué, J. Macrophage binding to receptor VCAM-1 transmits survival signals in metastatic breast cancer cells that invade the lungs. Cancer Cell 20, 538-549 (2011).
Aragón, E., Goerner, N., Zaromytidou, A.-I., Xi, Q., Escobedo, A., Massagué, J.*, Macias, M.J. A Smad action-turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev. 25, 1275-1288 (2011).
Oskarsson, T., Acharyya, S., Zhang, X.H.F, Tavazoie, S., Morris, P.G., Downey, R., Manova-Todorova, K., Brogi, E. and Massagué, J. Breast cancer cells produce tenascin-C as a metastatic niche component to colonize the lungs. Nature Med. 17, 867-874 (2011).
Alarcon, C., Zaromytidou, A.I., Xi, Q., Gao, S., Yu, J., Fujisawa, S., Barlas, A., Miller, A.N., Manova-Todorova, K., Macias, M.J., Sapkota, G., Pan, D. and Massague, J., Nuclear CDKs drive Smad transcriptional action and turnover in BMP and TGF-beta pathways. Cell 139, 757-769 (2009).
Gao, S., Alarcon, C., Sapkota, G., Rahman, S., Chen, P-Y., Goerner, N., Macias, M.J., Erdjument-Bromage, H., Tempst, P. and Massague, J., Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol. Cell 36, 457-468 (2009).
Kim, M-Y., Oskarsson, T., Acharyya, S., Nguyen, D.X., Zhang, X. H-F., Norton, L. and Massague, J., Tumor self-seeding by circulating cancer cells. Cell 139, 1315-1326 (2009).
Bos, P.D., Zhang, X.H-F, Nadal, C., Shu, W., Gomis, R.R., Nguyen, D.X., Minn, A.J., van de Vijver, M.J., Gerald, W.L., Foekens, J.A. and Massague, J., Genes that mediate breast cancer metastasis to the brain. Nature 459: 1005-1009 (2009)
Zhang, X.H-F, Wang, Q., Gerald, W.L., Hudis, C.A., Norton, L., Smid, M., Foekens, J.A. and Massague, J., Laten bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell 16: 67-78 (2009)
Nguyen, D.X., Chiang, A.C., Zhang, X.H-F, Kim, J.Y., Kris, M.G., Ladanyi, M., Gerald, W.L. and Massague, J., WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell 138: 51-62 (2009)
Tavazoie, S.F., Alarcon, C., Oskarsson, T., Padua, D., Wang, Q., Bos, P.D., Gerald W.L. and Massague, J., Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451: 147-152 (2008)
Padua, D., Zhang, X.H., Wang, Q., Nadal, C., Gerald W.L., Gomis, R.R. and Massague, J., TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 133: 66-77 (2008)
Gupta, G.P., Nguyen, D.X., Chiang, A., Kim, J.Y., Nadal, C., Gomis, R.R., Manova-Todorova, K. and Massagu-, J., Mediators of vascular remodeling co-opted for sequential steps in lung metastasis. Nature 446, 765-770 (2007)
Sapkota, G., Alarcon, C., Spagnoli, F., Brivanlou, A.H. and Massagué, J., Balancing BMP signaling through integrated inputs into the Smad1 linker. Mol. Cell 25, 441-454 (2007)
He, W., Dorn, D.C., Erdjument-Bromage, H., Tempst, P. Moore, M.A.S., Massagué, J., Hematopoiesis controlled by distinct TIF1-gamma and Smad4 branches of the TGF-beta pathway. Cell, 125, 929-941 (2006)
Minn, A.J., Gupta, G.P., Siegel, P.M., Bos, P.D., Shu, W., Giri, D.D., Viale, A., Olshen, A.B., Gerald W.L. and Massagué, J., Genes that mediate breast cancer metastasis to lung. Nature 436, 518-524 (2005)
Review Articles
Comen, E. Norton, L. and Massagué, J. Clinical implications of cancer self-seeding. Nature Rev. Clin. Oncol. 8, 369-377 (2011).
Nguyen, D.X, Bos, P.D. and Massagué, J. Metastasis: from dissemination to organ-specific colonization. Nature Rev. Cancer 9, 274-284 (2009).
Massague, J., TGF-beta in Cancer. Cell 134: 215-230 (2008).
Chiang, A.C. and Massague, J., Molecular basis of metastasis. N. Engl. J. Med. 359: 2814-2823 (2008).
Nguyen, D.X. and Massagué. J., Genetic determinants of cancer metastasis. Nature Rev. Genetics 8, 341-352 (2007).
Gupta, G.P. and Massagué, J., Cancer metastasis: building a framework Cell 127, 679-695 (2006).
Massagué, J., Seoane, J. and Wotton, D., Smad transcription factors. Genes Dev. 19, 2783-2810 (2005).
Shi, Y. and Massagué, J., Mechanisms of TGFb signaling from cell membrane to the nucleus. Cell 113, 685-700 (2003).
