Research Articles

Sevenich, L. Bowman, R.L., Mason, S.D., Quail, D.F., Rapaport, F., Elie, B.T., Brogi, E., Brastianos, P.K., Hahn, W.C., Holsinger, L.J., Massagué, J., Leslie, C.S. and Joyce, J.A.   A brain metastasis-promoting role for cathepsin S identified from analysis of tumor- and stroma-supplied proteolytic networks. Nature Cell Biol. In press (2014)

Vanharanta, S., Marney, C.B. Shu, W., Valiente, M., Zou, Y., Mele, A., Darnell R.B., and Massagué, J. Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer. eLife 2014;10.7554/eLife.02734

Morales, M., Arenas1, E.J., Urosevic, J., Guiu, M., Fernández, E., Planet, E., Fenwick, R.B., Fernández, S., Salvatella, X., Reverter, D., Carracedo, A., Massagué, J., Gomis, R.R. RARRES3 suppresses breast cancer lung metastasis by regulating adhesion and differentiation. EMBO Mol. Med. DOI: 10.15252/emmm.201303675   

Valiente, M., Obenauf, A.C., Jin, X., Chen, Q., Zhang, X.H.F., Lee, D.J., Chaft, J.E., Kris, M.G., Huse, J.T., Brogi, E. and Massagué, J. Serpins promote cancer cell survival and vascular cooption in brain metastasis. Cell. 2014 Feb 27;156(5):1002–1016.

Zhang, X. H.-F., Jin, X., Malladi, S., Kim, J.Y., Wen, Y.H., Brogi, E., Smid, M., Foekens, J. and Massagué, J. Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell. 2013 Aug 29;154(5):1060-73.

Vanharanta S, Shu W, Brenet F, Hakimi AA, Heguy A, Viale A, Reuter VE, Hsieh JJ, Scandura JM, Massagué J. Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Nature Med. 19, 50-56 (2013).

Acharyya S, Oskarsson T, Vanharanta S, Malladi S, Kim J, Morris PG, Manova-Todorova K, Leversha M, Hogg N, Seshan VE, Norton L, Brogi E, Massagué J. A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell 150, 165-178 (2012).

Xi Q, Wang Z, Zaromytidou AI, Zhang XH, Chow-Tsang LF, Liu JX, Kim H, Barlas A, Manova-Todorova K, Kaartinen V, Studer L, Mark W, Patel DJ, Massagué J. A poised chromatin platform for TGF-β access to master regulators. Cell 147, 1511-1524 (2011).

Chen Q, Zhang XH, Massagué J. Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell 20, 538-549 (2011).

Aragón, E., Goerner, N., Zaromytidou, A.-I., Xi, Q., Escobedo, A., Massagué, J.*, Macias, M.J. A Smad action-turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev. 25, 1275-1288 (2011).

Oskarsson, T., Acharyya, S., Zhang, X.H.F, Tavazoie, S., Morris, P.G., Downey, R., Manova-Todorova, K., Brogi, E. and Massagué, J. Breast cancer cells produce tenascin-C as a metastatic niche component to colonize the lungs. Nature Med. 17, 867-874 (2011).

Alarcon, C., Zaromytidou, A.I., Xi, Q., Gao, S., Yu, J., Fujisawa, S., Barlas, A., Miller, A.N., Manova-Todorova, K., Macias, M.J., Sapkota, G., Pan, D. and Massague, J., Nuclear CDKs drive Smad transcriptional action and turnover in BMP and TGF-beta pathways. Cell 139, 757-769 (2009).

Kim, M-Y., Oskarsson, T., Acharyya, S., Nguyen, D.X., Zhang, X. H-F., Norton, L. and Massague, J., Tumor self-seeding by circulating cancer cells. Cell 139, 1315-1326 (2009).

Bos, P.D., Zhang, X.H-F, Nadal, C., Shu, W., Gomis, R.R., Nguyen, D.X., Minn, A.J., van de Vijver, M.J., Gerald, W.L., Foekens, J.A. and Massague, J., Genes that mediate breast cancer metastasis to the brain. Nature 459: 1005-1009 (2009)

Zhang, X.H-F, Wang, Q., Gerald, W.L., Hudis, C.A., Norton, L., Smid, M., Foekens, J.A. and Massague, J., Laten bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell 16: 67-78 (2009)

Nguyen, D.X., Chiang, A.C., Zhang, X.H-F, Kim, J.Y., Kris, M.G., Ladanyi, M., Gerald, W.L. and Massague, J., WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell 138: 51-62 (2009)

Tavazoie, S.F., Alarcon, C., Oskarsson, T., Padua, D., Wang, Q., Bos, P.D., Gerald W.L. and Massague, J., Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451: 147-152 (2008)

Padua, D., Zhang, X.H., Wang, Q., Nadal, C., Gerald W.L., Gomis, R.R. and Massague, J., TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 133: 66-77 (2008)

Gupta, G.P., Nguyen, D.X., Chiang, A., Kim, J.Y., Nadal, C., Gomis, R.R., Manova-Todorova, K. and Massagu-, J., Mediators of vascular remodeling co-opted for sequential steps in lung metastasis. Nature 446, 765-770 (2007)

Minn, A.J., Gupta, G.P., Siegel, P.M., Bos, P.D., Shu, W., Giri, D.D., Viale, A., Olshen, A.B., Gerald W.L. and Massagué, J., Genes that mediate breast cancer metastasis to lung. Nature 436, 518-524 (2005)

Review Articles

Oskarsson, T., Batlle, E. and Massagué, J. Metastatic stem cells. Cell Stem Cell 14, 306-321 (2014).

Vanharanta, S. and Massagué, J. Origins of metastatic traits. Cancer Cell 24, 410-421 (2013). 

Massagué J. TGFβ signalling in context. Nat Rev Mol Cell Biol. 18, 5521-5525 (2012).

Nguyen, D.X, Bos, P.D. and Massagué, J. Metastasis: from dissemination to organ-specific colonization. Nature Rev. Cancer 9, 274-284 (2009).

Massague, J., TGF-beta in Cancer. Cell 134: 215-230 (2008).

Chiang, A.C. and Massague, J., Molecular basis of metastasis. N. Engl. J. Med. 359: 2814-2823 (2008).

Gupta, G.P. and Massagué, J., Cancer metastasis: building a framework Cell 127, 679-695 (2006).

Shi, Y. and Massagué, J., Mechanisms of TGFb signaling from cell membrane to the nucleus. Cell 113, 685-700 (2003).