I am head of the nuclear medicine physics section, which supports research in PET/CT, targeted therapies, and molecular imaging. As both a medical and biophysicist, I investigate nuclear imaging methodologies to define tumor targets in terms of their metabolic and microenvironmental properties. I have a special interest in the quantitative imaging of tumor hypoxia — a known factor in determining resistance to treatment — and in ways of precisely delivering radiotherapy to a tumor, including targeting radionuclides using antibodies that can home in on cancer cells to provide a diagnostic image as well as deposit a therapeutic dose.


Bartlett RM, Beattie BJ, Naryanan M, Georgi JC, Chen Q, Carlin SD, Roble G, Zanzonico PB, Gonen M, O'Donoghue J, Fischer A, Humm JL. Image-guided PO2 probe measurements correlated with parametric images derived from 18F-fluoromisonidazole small-animal PET data in rats. J Nucl Med. 2012 Oct;53(10):1608-15. doi: 10.2967/jnumed.112.103523. Epub 2012 Aug 29.

McCall KC, Humm JL, Bartlett R, Reese M, Carlin S. Copper-64-diacetyl-bis(N(4)-methylthiosemicarbazone) pharmacokinetics in FaDu xenograft tumors and correlation with microscopic markers of hypoxia. Int J Radiat Oncol Biol Phys. 2012 Nov 1;84(3):e393-9. doi: 10.1016/j.ijrobp.2012.05.005. Epub 2012 Jun 23.

Frey EC, Humm JL, Ljungberg M. Accuracy and precision of radioactivity quantification in nuclear medicine images. Semin Nucl Med. 2012 May;42(3):208-18. doi: 10.1053/j.semnuclmed.2011.11.003.

O'Donoghue JA, Smith-Jones PM, Humm JL, Ruan S, Pryma DA, Jungbluth AA, Divgi CR, Carrasquillo JA, Pandit-Taskar N, Fong Y, Strong VE, Kemeny NE, Old LJ, Larson SM. 124I-huA33 antibody uptake is driven by A33 antigen concentration in tissues from colorectal cancer patients imaged by immuno-PET. J Nucl Med. 2011 Dec;52(12):1878-85. doi: 10.2967/jnumed.111.095596. Epub 2011 Nov 8.

Schwartz J, Jaggi JS, O’Donoghue JA, Ruan S, McDevitt M, Larson SM, Scheinberg DA and Humm JL. Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody. Phys Med Biol. 2011 Feb 7;56(3):721-33. doi: 10.1088/0031-9155/56/3/012. Epub 2011 Jan 10.

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Selected Achievements

Loevinger-Berman Award, Society of Nuclear Medicine and Molecular Imaging (2012)

Fellow, American Association of Physicists in Medicine (2007)