Research in the Goldberg laboratory is focused on a molecular description of the mechanisms of vesicle transport and compartmentation in eukaryotic cells. We use x-ray crystallography to determine protein atomic structures and biochemical analyses to elucidate mechanisms.
Current studies encompass three areas:
Lee C, Goldberg J. Structure of coatomer cage proteins and the relationship among COPI, COPII, and clathrin vesicle coats. Cell. 2010 Jul 9;142(1):123-32. doi: 10.1016/j.cell.2010.05.030. Epub 2010 Jun 24.
Fath S, Mancias JD, Bi X, Goldberg J. Structure and organization of coat proteins in the COPII cage. Cell. 2007 Jun 29;129(7):1325-36.
Yu X, Breitman M, Goldberg J. A structure-based mechanism for Arf1-dependent recruitment of coatomer to membranes. Cell. 2012 Feb 3;148(3):530-42. doi: 10.1016/j.cell.2012.01.015.
Bi X, Mancias JD, Goldberg J. Insights into COPII coat nucleation from the structure of Sec23.Sar1 complexed with the active fragment of Sec31. Dev Cell. 2007 Nov;13(5):635-45.
