The immune system responds to viral infections by introducing a complex interplay of immune cells and factors, whose goal is to eliminate the intruding pathogen. One such effector cell in the antiviral response is the Natural Killer (NK) cell, which secretes inflammatory cytokines and directly kills infected cells. The focus of our research is aimed at defining the signals that NK cells require to mount an effective immune response against pathogens. We are also exploring the regulatory mechanisms keeping NK cells in check, thereby safeguarding against potential autoimmunity.

Publications

Beaulieu AM, Zawislak CL, Nakayama T, Sun JC.  2014.  The transcription factor Zbtb32 controls the proliferative burst of virus- specific NK cells responding to infection. Nat Immunol.  15:546-53.

Firth MA, Madera S, Beaulieu AM, Gasteiger G, Castillo EF, Schluns KS, Kubo M, Rothman PB, Vivier E, Sun JC.  2013.  Nfil3-independent lineage maintenance and anti-viral response of natural killer cells.  J Exp Med.  210:2981-90.

Zawislak CL, Beaulieu AM, Loeb GB, Karo J, Canner D, Bezman NA, Lanier LL, Rudensky AY, Sun JC.  2013.  Stage-specific regulation of Natural Killer cell homeostasis and response against viral infection by microRNA-155.  Proc Natl Acad Sci U S A.  110:6967-72.

Sun JC, Madera S, Bezman NA, Beilke JN, Kaplan MH, Lanier LL.  2012.  Proinflammatory cytokine signaling required for the generation of natural killer cell memory.  J Exp Med.  209:947-54. 

Sun JC, Beilke JN, Lanier LL.  2009.  Adaptive immune features of natural killer cells.  Nature  457:557-61.

Office phone:
646-888-3228
Office fax:
646-422-0452
Laboratory phone:
646-888-3237
E-mail:
sunj@mskcc.org
Selected Achievements

Geoffrey Beene Junior Faculty Chair (2014)

AAI Pfizer-Showell Early Career Investigator Award (2012)

Searle Scholar Award (2011)

Cancer Research Institute Investigator Award (2011)

NIH K99 Career Development Award (2010)