Kathryn V. Anderson, PhD

Chair, Developmental Biology Program, SKI
Pictured: Kathryn Anderson
Office phone:
212-639-6485
Office fax:
646-422-2355
Laboratory phone:
212-639-6543
Research topics:
Cell Biology; Cell Signaling; Gene Regulation; Genetics & Genomics; Immunology; Neuroscience; Protein Folding & Trafficking; Stem Cell Biology

Genes that Control Mouse Embryogenesis

We use a genetic approach to identify new genes that control important events in early mouse embryogenesis. We screen for recessive, ENU- induced mutations that cause clear morphological abnormalities at midgestation. Using the completed mouse genome sequence, it is now straightforward to identify the genes responsible for the mutant phenotypes.

This project is a component of the Sloan-Kettering Mouse Project: a collaborative project to screen for mutants that affect 3 stages of mouse embryogenesis. The project has identified more than 100 mutations with clear effects on mouse embryonic. Studies in our lab focus on two classes of mutations: genes that control cell type specification in the nervous system and genes that control specification and morphogenesis of the body axis. In these studies, we have found that there are close connections between embryonic development and cell biology.

Mutations that affect embryonic morphogenesis

Mutations that affect embryonic morphogenesis and patterning act at the level of cell biology. Mesodermal cells from Nap1khlo embryos lack normal lamellipodia (left); many of the Nap1khlo embryos have duplications of the anterior-posterior body axis. The organization of the microtubule axoneme of cilia is abnormal in Arl13bhnn embryos (right); Hedgehog signaling and neural patterning are also abnormal in these embryos.