The Kim lab is interested in the role that epigenetic regulation plays in pluripotency and cancer. Specifically, we are using comparative methylome studies to assess genome-wide patterns of methylation in cells derived from various tissue types and donors, including pluripotent stem cells generated via multiple methodologies. The goal of these studies is to identify the mechanisms that regulate DNA methylation and to define their contribution to the cell's ability to self-renew, differentiate, and function normally.