Our research group studies the utility of different methods to characterize the chronic and long-term adverse cardiovascular side effects of conventional and novel cancer therapies. By investigating the use of these tools, we can better understand how cancer therapeutics damage organs such as the heart and skeletal muscles, as well as identify those individuals at high risk of cardiovascular side effects. In doing so, we can design therapeutic interventions to prevent and/or mitigate these devastating side effects.

Publications

Jones LW, Douglas PS, Khouri MG, Mackey JR, Wojdyla D, Kraus WE, Whellan DJ, O’Connor CM. Safety and efficacy of aerobic training in cancer patients with clinically-stable heart failure: An analysis of the HF-ACTION randomized trial. Journal of Clinical Oncology. In Press.

Betof AS, Lascola CD, Fowler E, Scarbrough PM, Jones LW*, Dewhirst MW*. Exercise inhibits tumor progression and sensitizes tumors to chemotherapy in orthotopic models of breast cancer. Journal of the National Cancer Institute. In Press.

Jones LW, Hornsby WE, Freedland SJ, Lane A, West MJ, Moul JW, Ferrandino MN, Allen JD, Kenjale AA, Thomas SM, Herndon JE, Koontz BF, Chan J, Khouri MG, Douglas PS, Eves ND. Effects of non-linear aerobic training on erectile dysfunction and cardiovascular function following radical prostatectomy for clinically-localized prostate cancer. European Urology, 2013.

Jones LW, Fels DR, West MJ, Allen JD, Broadwater G, Barry WT, Wilke LG, Masko E, Douglas PS, Dash RC, Povsic TJ, Peppercorn J, Marcom PK, Blackwell KL, Kimmick G, Turkington T, Dewhirst MW. Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy. Cancer Prevention Research, 2013; 6(9):925-37.

Jones LW, Courneya KS, Mackey JR, Muss HB, Pituskin EN, Scott JM, Hornsby WE, Coan AD, Herndon JE, Douglas PS, Haykowsky M. Cardiopulmonary function and age-related decline across the breast cancer survivorship continuum. Journal of Clinical Oncology, 2012;30:2530-7.