Malcolm A. S. Moore, DPhil

The laboratory undertakes research on the hematopoietic stem cells and progenitor populations, in normal mice and humans, and in neoplastic and genetic diseases. The laboratory has a long history of the using in vitro clonogenic assays for characterization of factors (e.g. G-CSF) involved in differentiation of hematopoietic progenitor cells into mature cells (Fig1). Subsequent studies, utilizing in vitro stem cell assays (Fig 2), have been directed at factors influencing stem cell proliferation, particularly cytokines favoring self-renewal rather than differentiation (ligands for c-Kit and flk2/flt3, Interleukins-1, -6, -11, thrombopoietin). Currently, retroviral, lentiviral and adenoviral gene delivery systems are being used to modify human stem cells self-renewal, differentiation and migration by introduction of genes for telomerase, Notch, CXCR4 and the HOX family. The process of leukemogenesis is being studied by transduction of normal human stem cells with leukemogenic genes such as bcr-abl, AML-ETO, Nup98/HOXA9 and mutated forms of Flt3 and Ras.

Publications

Lee J, Shieh JH, Zhang J, Liu L, Zhang Y, Morrone G, Moore MAS, and Zhou P.  Improved ex vivo expansion of adult hematopoietic stem cells by overcoming CUL4-mediated degradation of HOXB4. BLOOD. Blood. 2013 May 16;121(20):4082-9. doi: 10.1182/blood-2012-09-455204. Epub 2013 Mar 21. PMID: 23520338

Hartwell KA, Peter G Miller PG, Mukherjee S, Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M, Järås M, Puram R, Dancik V, Al-Shahrour F, Kindler T, Tothova Z, Chattopadhyay S, Hasaka T, Narayan R, Dai M, Huang C, Shterental S, Chu LP, Haydu JE, Shieh J-H, Steensms DP, Munoz B, Bittker JA, Shamji AF, Clemons PA, Tolliday NJ, Carpenter AE, Gilliland DG, Stern AM, Moore MAS*, Scadden DT*, Schreiber SL*, Ebert BL*, Golub TR*.  Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. Nat Chem Biol. 2013 Dec;9(12):840-8. *co-senior authors  PMID:24161946

Wang P, Dong S, Shieh JH, Peguero E, Hendrickson R, Moore MA, Danishefsky SJ. Erythropoietin derived by chemical synthesis. Science. 2013 Dec 13;342 PMID: 24337294

Ambati SR, Lopes EC, Kosugi K, Mony U, Zehir A, Shah SK, Taldone T, Moreira AL, Meyers PA, Chiosis G, Moore MA. Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma. Mol Oncol. 2013 Dec 15. pii: S1574-7891(13)00177-4. PMID: 24388362

Thayanithy V, Babatunde V, Dickson E, Wong P, Oh S,  Ke X, Barlas A, Sho  Fujisawa S, Romin Y, Moreira A, Downey R, Steer C, Subramanian S, Manova-Todorova K, Moore MA,  Lou E.  Tumor Exosomes Induce Tunneling Nanotubes in Lipid Raft-Enriched Regions of Human Mesothelioma Cells.  Exp Cell Res. 2014 Jan 24. 323(1): 178-188. PMID: 24468420

Office phone:
212-639-7090
Office fax:
212-717-3618
Laboratory phone:
212-639-8171
Laboratory fax:
212-717-3618