Hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for a variety of hematological malignancies. Despite improvements in the overall survival of transplant recipients, infections and disease relapse remain the major causes of post-transplant morbidity and mortality. In addition, the widespread use of HSCT it has been limited by the onset of graft-versus-host disease (GVHD)
My current projects include:
- I am interested in the development of strategies to regenerate the immune system after HSCT. Currently, I am addressing the role and molecular basis of chemical castration as a tool to reconstitute the immune system through the use of experimental models.
- Several laboratories have demonstrated that T regulatory cells are capable of inhibiting GVHD without impacting the Graft-versus-tumor response. The main obstacle to clinical application of Tregs in humans is their paucity in peripheral blood. I am investigating novel experimental models to expand Tregs in vitro and in vivo and to use them as a tool in preventing GVHD.