My career aim is to develop and evaluate strategies that improve outcomes after hematopoietic stem cell transplantation (HSCT), in particular by augmenting graft-versus-tumor (GVT) to reduce the rates of malignant relapse and alleviating graft-versus-host disease (GVHD). To this goal, I have studied therapies that modulate alloreactive T cells in GVT and GVHD, using mouse models of HSCT.
To develop strategies of augmenting anti-tumor immunity following HSCT, I have focused in particular on T cell repertoire enhancement strategies. Simultaneously, I have begun to study the T cell repertoire in the setting of GVHD. Finally, I have also examined how aspects of mucosal immunology can impact on intestinal GVHD, including the microbial flora and dietary factors.