Targeting of Proteins to Membranes by Fatty Acylation

We are investigating the role of myristate and palmitate in targeting proteins to membranes and to plasma membrane microdomains known as rafts.

Lipid Modification of Hedgehog Proteins

Modification of Hedgehog proteins by palmitate and cholesterol.

Hedgehog Palmitoylation as a Target to Block Pancreatic Cancer

Inhibitors of Hhat (hedgehog acyltransferase) are being used in the study of pancreatic cancer cell growth.