Marilyn Resh: Publications

Patwardhan, P. and Resh, M.D. (2010) Myristoylation regulates c-Src protein stability and tyrosine kinase activity. Mol. Cell. Biol. 30:4094-4107.

Buglino, J. and Resh, M.D. (2010) Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic hedgehog. PLoS ONE 5(6): e11195. doi:10.1371/journal.pone.0011195.

See, W.L., Heinberg, A.R., Holland, E.C., and Resh, M.D. (2010) p27 deficiency is associated with migration defects in PDGF-expressing gliomas in vivo. Cell Cycle 9:1562-1567.

See, W.L., Miller, J.P., Squatrito, M., Holland, E.C., Resh, M.D. and Koff, A. (2010) Defective DNA double-strand break repair underlies enhanced tumorigenesis and chromosomal instability in p27 deficient mice with growth-factor induced oligodendrogliomas. Oncogene 29: 1720-1731.

Martinez, N.W., Xue, X., Berro, R.G., Kreitzer, G., and Resh, M.D. (2008) The kinesin KIF4 regulates intracellular trafficking and stability of the HIV-1 Gag polyprotein. J. Virol.82: 9937-9950.

Buglino, J. and Resh, M.D. (2008) Hhat is a palmitoyl acyltransferase with specificity for N-palmitoylation of Sonic Hedgehog. J. Biol. Chem. 283:22076-88.

Donepudi, M. and Resh, M.D. (2008) c-Src trafficking and co-localization with the EGF Receptor promotes EGF ligand-independent EGF Receptor Activation and Signaling. Cell Signal. 20: 1359-1367.

Valiathan, R. and Resh, M.D. (2008) Differential control of CXCR4 and CD4 downregulation by HIV-1 Gag. Virology J. 5:23.

Resh, M.D. (2006) Palmitoylation of intracellular signaling molecules. Science STKE (359), re14 [DOI: 10.1126/stke.3592006re14].

Resh, M.D. (2006) Trafficking and Signaling by Fatty Acylated and Prenylated Proteins. Nature Chem. Biol. 2: 584-590.

Valiathan, R. and Resh, M.D. (2004) Expression of HIV-1 Gag modulates ligand-induced down-regulation of the EGF Receptor. J. Virol. 78:12386-12394

Resh, M.D. (2004) Membrane targeting of lipid modified signal transduction proteins. In Subcellular Biochemistry: Membrane Dynamics and Domains. Vol. 37 Kluwer Academic/Plenum Publishers (P.J. Quinn, ed.), 217-232.

Wolf, R.M., Draghi, N., Liang, X., Dai, C., Uhrbom, L., Eklof, C., Westermark, B., Holland, E.C. and Resh, M.D. (2003) p190RhoGAP can act to Inhibit PDGF induced Gliomas in Mice: A Putative Tumor Suppressor Encoded on Human Chromosome 19q13.3. Genes and Dev. 17: 476-487.

Liang, X., Draghi, NA and Resh, M.D. (2004) Signaling from Integrins to Fyn to Rho family GTPases regulates oligodendrocyte differentiation. J. Neurosci. 24: 24:7140-7149.

Liang, X., Lu, Y., Neubert, T. and Resh, M.D. The N-terminal SH4 region of the Src family kinase Fyn is modified by methylation and heterogeneous fatty acylation: Role in membrane targeting, cell adhesion and spreadi. J. Biol. Chem 2004; 279: 8133-8139

Lindwasser, O.W., Resh, M.D. . HIV-1 Gag contains a dileucine-like motif that regulates association with multivesicular bodies.. J. Virol. 2004; 78: 6013-6023

Resh MD. A myristoyl switch regulates membrane binding of HIV-1 Gag.. Proc. Natl. Acad. Sci USA 2004; 101: 417-418

Webb. Y., Hermida-Matsumoto, L. and Resh, M.D. (2000) Inhibition of protein palmitoylation, raftlocalization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids. J. Biol. Chem. 275: 261-270.

van't Hof, W. and Resh, M.D. (1999) Dual fatty acylation of p59fyn is Required for Association with the T Cell Receptor Zeta Chain through Phosphotyrosine-Src Homology Domain-2 Interactions. J. Cell Biol. 145: 377-389.

Chen, X. and Resh, M.D. (2001) Activation of Mitogen-Activated Protein Kinase by Membrane Targeted Raf Chimeras is Independent of Raft Localization. J. Biol. Chem. 276: 34617-34623.

Wolf, R.M., Wilkes, J., Chao, M. and Resh, M.D. (2001) Phosphorylation of p190RhoGAP by Fyn Regulates Process Extension During Oligodendrocyte Differentiation. J. Neurobiol. 49:62-78.

Liang, X., Nazarian, A.; Erdjument-Bromage, H.; Bornmann, W., Tempst, P. and Resh, M.D. (2001) Heterogeneous Fatty Acylation of Src Family Kinases with Polyunsaturated Fatty Acids Regulates Raft Localization and Signal Transduction. J. Biol. Chem. 276: 30987-30994.

Lindwasser, O.W. and Resh, M.D. (2001) Multimerization of HIV-1 Gag Promotes its Localization to Barges, Raft-Like Membrane Microdomains. J. Virol. 75:7913-7924.

Hermida-Matsumoto, L. and Resh, M.D. (2000) Localization of HIV-1 Gag and Env at the Plasma Membrane by Confocal Imaging. J. Virol. 74: 8670-8679. [Cover Photo - J. Virol. March 2001, Volume 75, Issue 5].

Tritel, M. and Resh, M.D. (2000) Kinetic Analysis of HIV-1 Assembly Reveals the Presence of Sequential Intermediates. J. Virol. 74: 5845-5855.

Chen, X. and Resh, M.D. (2002) Cholesterol Depletion from the Plasma Membrane Triggers Ligand-Independent Activation of the EGF Receptor. J. Biol. Chem. 277: 49631-49637.

Lindwasser, O.W. and Resh, M.D. (2002) Myristoylation as a Target for Inhibiting HIV-1 Assembly: Unsaturated Fatty Acids Block Viral Budding. Proc. Natl. Acad. Sci. USA: 99:13037-13042.

Liang, X., Lu, Y., Neubert, T., and Resh, M.D. (2002) Mass Spectrometric Analysis of GAP-43/Neuromodulin Reveals the Presence of a Variety of Fatty Acylated Species. J. Biol. Chem. 277:33032-33040.