The goal of my laboratory's research is to understand how fatty acylation influences the structure and function of membrane-bound and secreted signaling proteins. Our focus is on the Src family tyrosine protein kinases and Hedgehog proteins.

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Laboratory phone:
212-639-2551 / 2552
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Selected Achievements

Excellence in Teaching and Mentoring Award, Weill Cornell Graduate School (2009)

Established Scientist, American Heart Association (1994-1999)

Pew Scholar in the Biomedical Sciences, Pew Charitable Trusts (1987-1991)

Discovery of the “”two-signal hypothesis”” for binding of myristoylated proteins to membranes

Discovery of a myristoyl switch mechanism for membrane binding of HIV-1 Gag

First to establish Hedgehog acyltransferase as a bona fide palmitoyl acyltransferase for Hedgehog proteins

Discovery of the first-in-class hedgehog palmitoylation inhibitor