Michael S. Glickman: Publications

Peer-reviewed Journals

Landry, D.W., Zhao, K., Yang, G.X., Glickman, M., and Georgiadis, T.M. 1993. Antibody- catalyzed degradation of cocaine. Science 259:1899-1901.

Glickman, M., and Klein, R.S. 1997. Acute epiglottitis due to Pasteurella multocida in an adult without animal exposure. Emerg Infect Dis 3:408-409.

Glickman, M.S., Cox, J.S., and Jacobs, W.R., Jr. 2000. A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis. Mol Cell 5:717-727.

Glickman, M.S., Cahill, S.M., and Jacobs Jr., W.R. 2001. The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans cyclopropane synthetase. J Biol Chem. 276: 2228-33.

Glickman, M.S., and Jacobs, W.R., Jr. 2001. Microbial pathogenesis of Mycobacterium tuberculosis: dawn of a discipline. Cell 104:477-485.

Huang, C.C., Smith, C.V., Glickman, M.S., Jacobs, W.R., Jr., and Sacchettini, J.C. 2002. Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis. J Biol Chem 277:11559-11569.

Glickman, M.S. 2003. The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the alpha-mycolic acid. J Biol Chem 278:7844-7849.

Otero, J., Jacobs, W.R., Jr., and Glickman, M.S. 2003. Efficient allelic exchange and transposon mutagenesis in Mycobacterium avium by specialized transduction. Appl Environ Microbiol 69:5039-5044.

Gong, C., Martins, A., Bongiorno, P., Glickman*, M., and Shuman*, S. 2004. Biochemical and genetic analysis of the four DNA ligases of mycobacteria. J Biol Chem 279:20594-20606. *Corresponding Authors.

Rao, V., Fujiwara, N., Porcelli, S.A., and Glickman, M.S. 2005. Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule. J Exp Med 201:535-543.

Gong, C., Bongiorno, P., Martins, A., Stephanou, N.C., Zhu, H., Shuman*, S., and Glickman*, M.S. 2005. Mechanism of nonhomologous end-joining in mycobacteria: a low-fidelity repair system driven by Ku, ligase D and ligase C. Nat Struct Mol Biol 12:304-312. *Corresponding Authors.

Makinoshima, H., and Glickman, M.S. 2005. Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysis. Nature 436:406-409.

Akey, D., Martins, A., Aniukwu, J., Glickman, M.S., Shuman, S., and Berger, J.M. 2006. Crystal structure and nonhomologous end-joining function of the ligase component of Mycobacterium DNA ligase D. J Biol Chem 281:13412-13423.

Zhu, H., Nandakumar, J., Aniukwu, J., Wang, L.K., Glickman, M.S., Lima, C.D., and Shuman, S. 2006. Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D. Proc Natl Acad Sci U S A 103:1711-1716.

Rao, V., Gao, F., Chen, B., Jacobs, W.R., Jr., and Glickman, M.S. 2006. Trans-cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis -induced inflammation and virulence. J Clin Invest 116:1660-1667.

  • Commentary: Riley LW. Of mice, men, and elephants: Mycobacterium tuberculosis cell envelope lipids and pathogenesis. J Clin Invest. 2006 116(6):1475-8

Sinha, K.M., Stephanou, N.C., Gao, F., Glickman*, M.S., Shuman*, S. 2006. Mycobacterial UvrD1 is a Ku-dependent DNA helicase that plays a role in multiple DNA repair events, including double-strand break repair. J Biol Chem 282: 15114-15125. *Corresponding Authors.

Makinoshima, H., and Glickman, M.S. 2006. Site-2 proteases in prokaryotes: regulated intramembrane proteolysis expands to microbial pathogenesis. Microbes Infect 8:1882-1888.

Stephanou, N.C., Gao, F., Bongiorno, P., Ehrt, S., Schnappinger, D., Shuman, S., Glickman, M.S. 2007. Mycobacterial Nonhomologous End Joining Mediates Mutagenic Repair of Chromosomal Double-Strand DNA Breaks. J Bacteriol. 189(14):5237-46. Epub 2007 May 11.

Martiniuk F., Rao S.D., Rea T.H., Glickman M.S., Giovinazzo J., Rom W.N., Cabrera A., Levis W.R. 2007. Leprosy as immune reconstitution inflammatory syndrome in HIV-positive persons. Emerg Infect Dis 13:1438-1440.

Shuman, S., and Glickman, M.S. 2007. Bacterial DNA repair by non-homologous end joining. Nat Rev Microbiol 5: 852-861.

Velmurugan K., Chen B., Miller J.L., Azogue S., Gurses S., Hsu T., Glickman M., Jacobs Jr. W.R., Porcelli S.A., Briken V. 2007. Mycobacterium tuberculosis nuoG Is a virulence gene that inhibits apoptosis of infected host cells. Plos Pathog 3: 972-980.

Aniukwu J., Glickman M.S.*, Shuman S*. 2008. The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends. Genes Dev 22: 512-27. *Co-Corresponding Authors.

  • Commentary: Gu, J and Lieber, MR . Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining. Genes Dev. 15;22(4):411-5

Sinha, K.M., Stephanou, N.C., Unciuleac, M.C., Glickman M.S.*, and Shuman S*. 2008. Domain requirements for DNA unwinding by mycobacterial UvrD2, an essential DNA helicase. Biochemistry 47:9355-64. Epub 2008 Aug 15. *Co-Corresponding Authors.

Gallegos, A.M., Pamer, E.G. *, and Glickman, M.S.* 2008. Delayed protection by ESAT-6 specific effector CD4+ T cells following airborne M. tuberculosis infection. J Exp Med 205:2359-68. Epub 2008 Sep 8. *Co-Corresponding Authors.

Kamboj, M., Louie, E., Kiehn, T., Papanicolaou, G., Glickman, M., and, Sepkowitz, K. Mycobacterium haemophilum infection after alemtuzumab treatment. 2008 Emerg Infect Dis 14: 1821-3.

El-Hajj, H.H., Marras, S.A., Tyagi, S., Shashkina, E., Kamboj, M., Kiehn, T.E., Glickman, M.S., Kramer, F.R., and Alland, D. 2009. Use of sloppy molecular beacon probes for identification of mycobacterial species. J Clin Microbiol 47: 1190-8. Epub 2009 Jan 26.

Sinha, K.M, Glickman, M.S., Shuman, S. 2009. Mutational analysis of Mycobacterium UvrD1 identifies functional groups required for ATP hydrolysis, DNA unwinding, and chemomechanical coupling. Biochemistry 49: 4019-4030.

Barkan, D., Lui, Z., Sacchettini, J.C., and Glickman, M.S. 2009. Mycolic acid cyclopropanation is essential for viability, drug resistance and cell wall integrity of Mycobacterium tuberculosis. Chem and Biol 16: 499-509.

Sinha, K.M., Unciuleac, M.C., Glickman, M.S., and Shuman, S. 2009. AdnAB: a New DSB-resecting Motor-Nuclease from Mycobacteria. Genes Dev 23: 1423-1437.

Stallings, C.L., Stephanou, N.C., Chu, L., Hochschild, A., Nickels, B.E., and Glickman, M.S. 2009. CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence. Cell 138: 146-159.

  • Commentaries
    Connolly, L.E., Cox, J.S. CarD tricks and magic spots: mechanisms of stringent control in mycobacteria. Cell Host Microbe. 2009 6(1):1-2.
    Molloy, S. Another CarD in the pack Nature Reviews Microbiology7, 618.

Barkan, D., Rao, V., Sukenick, G.D., andGlickman, M.S. 2010 Redundant Function of cmaA2 and mmaA2In Mycobacterium tuberculosis Cis-Cyclopropanation of Oxygenated Mycolates. J Bacteriol. 192:3661-8. Epub 2010 May 14.

Sklar, J., Makinoshima, H., Schneider, J., and Glickman, M.S. 2010. M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates. Mol Microbiol. 77: 605-17. Epub 2010 Jun 1. [PMCID:PMC3008510]

Stallings, C. and Glickman, M.S. 2010. Is Mycobacterium tuberculosis stressed out? A critical assessment of the genetic evidence. Microbes Infect. 12:1091-101. Epub 2010 Aug 5.

Barkan, D., Stallings, C.L., and Glickman, M.S. 2011. An improved counterselectable marker system for mycobacterial recombination using galK and 2-Deoxy-Galactose. Gene. 470: 31-36. Epub 2010 Sep 17.

Gupta, R., Barkan, D., Redelman-Sidi, G., Shuman, S., and Glickman, M.S. 2011. Mycobacteria exploit three genetically distinct DNA double-strand break repair pathways. Mol Microbiol. 79:316-30. Epub 2010 Nov 24. PMC Journal - In Process.

  • Commentary: Warner, D.F. and Mizrahl, V. 2011. Making ends meet in mycobacteria. Mol Microbiol. 79:283-7.

Gallegos, AM., van Heijst, J.W.J., Samstein, M., Su, X., Pamer, E.G., and Glickman, M.S. 2011. A Gamma Interferon Independent Mechanism of CD4 T Cell Mediated Control of M. tuberculosis infection in vivo. PLoS Pathog 7: e1002052. doi:10.1371/journal.ppat.1002052.

Stallings, C.L., Chu, L., Li, L.X., and Glickman, M.S. 2011. Catalytic and non-catalytic roles for the mono-ADP-ribosyltransferase Arr in the mycobacterial DNA damage response. PLoS One 6(7):e21807. Epub 2011 Jul 18.

Meyer, R., Rappo, U., Glickman, M., Seo, S.K., Sepkowitz, K., Eagan, J., Small, T.N. 2011. Legionella jordanis in hematopoietic SCT patients radiographically mimicking invasive mold infection. Bone Marrow Transplant 46:1099-103. doi: 10.1038/bmt.2011.94. PMC Journal - In Process.

Glickman, M.S. and Sawyers, C.L. 2012. Converting cancer therapies into cures: lessons from infectious diseases. Cell 148: 1089-98.

Barkan, D., Hedhli, D., Yan, H.G., Huygen, K., and Glickman, M.S. 2012. M. tuberculosis lacking all mycolic acid cyclopropanation is viable but highly attenuated and hyperinflammatory in mice. Infect Immun 80: 1958-68. Epub 2012 Mar 19.

Huang, G., Redelman Sidi, G., Rosen, N., Glickman, M.S., and Jiang, X. 2012. Inhibition of mycobacterial infection by the tumor suppressor PTEN. JBiol Chem. 287:23196-202. Epub 2012 May 21.

Weiss, L.A., Harrison, P.G., Nickels, B.E., Glickman, M.S., Campbell, E.A., Darst, S.A., Stallings, C.L. 2012. The Interaction of CarD with RNAP Mediates Mycobacterium tuberculosis Viability, Rifampicin Resistance, and Pathogenesis. J Bacteriol. 194: 5621-31. Epub 2012 Aug 17.

Zhu, H., Bhattarai, H., Yan H., Shuman, S., and Glickman, M.S. 2012. Characterization of Mycobacterium smegmatis PolD2 and PolD1 as RNA/DNA polymerases homologous to the POL domain of bacterial DNA ligase D. Biochemistry. 51: 10147-58. Epub 2012 Dec 11.

Gupta, R., Ryzhikov, M., Koroleva, O., Unciuleac, M., Shuman, S., Korolev, S., Glickman, M.S. 2012. A dual role for mycobacterial RecO in RecA-dependent homologous recombination and RecA-independent single-strand annealing. Nucleic Acids Res. 2013 Jan 7. [Epub ahead of print]. PMC Journal - In Process.

Redelman-Sidi, G., Iyer, G., Solit, D., and Glickman, M.S. 2013. Oncogenic activation of Pak1 dependent Macropinocytosis pathway determines BCG entry into bladder cancer cells. Cancer Res. 2013 Feb 1;73(3):1156-67. doi: 10.1158/0008-5472.CAN-12-1882.

Srivastava D.B, Leon K., Osmundson J., Garner A.L., Weiss L.A., Westblade L.F., Glickman, M.S., Landick R., Darst S.A., Stallings C.L., Campbell, E.A. 2013.  Structure and function of CarD, an essential mycobacterial transcription factor. Proc Natl Acad Sci USA 110:12619-24.

Schneider, J.S. and Glickman, M.S. 2013. Function of site-2 proteases in bacteria and bacterial pathogens. Biochim Biophys Acta. 2013 Dec;1828(12):2808-14. doi: 10.1016/j.bbamem.2013.04.019.

Hedhli,, D. Barkan, D. Daffe, M. Glickman and Huygen, K.  M . tuberculosis mutants lacking oxygenated mycolates show increased immunogenicity and protective efficacy as compared to M. bovis BCG vaccine in an experimental mouse model. PLoS One. 2013 Oct 17;8(10):e76442. doi: 10.1371/journal.pone.0076442.

Miriam Samstein, Heidi A. Schreiber, Ingrid M. Leiner, Bože Sušac, Michael S. Glickman, Eric G. Pamer.  Essential yet limited role for CCR2+ inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming. Elife. 2013 Nov 12;2:e01086. doi: 10.7554/eLife.01086.

Jessica S Schneider , Shilpa R Reddy , Hock Y E , Henry Evans , Michael S. Glickman. Site-2 protease substrate specificity and coupling in trans by a PDZ-substrate adapter protein. Proc Natl Acad Sci U S A 2013 Nov 26;110(48):19543-8

Schneider, JS., Sklar, J, and Glickman M.S. The Rip1 protease of M. tuberculosis controls the SigD regulon. J Bacteriol. 2014 May; 196(14):2638-45.

Brook Heaton, Dan Barkan, Paola Bongiorno, Petros Karakousis, Michael S. Glickman. Deficiency of double strand DNA break repair does not impair M. tuberculosis virulence in multiple animal models of infection.  Infect Immun. 2014 Aug; 82(8):3177-85. doi: 10.1128/IAI.01540-14. Epub 2014 May 19.

Redelman-Sidi G, Glickman MS, Bochner BH. The mechanism of action of BCG therapy for bladder cancer—a current perspective. Nat Rev Urol. 2014 Mar;11(3):153-62.

Robert Landick, Azra Krek, Michael S. Glickman, Nicholas D. Socci, and Christina L.  Stallings. Genome-Wide Mapping of the Distribution of CarD, RNAP σA, and RNAP β on the Mycobacterium smegmatis Chromosome using Chromatin Immunoprecipitation Sequencing. Genom Data. 2014 Dec;2:110-113

Allison Fay and Michael S. Glickman. An essential nonredundant role for mycobacterial DnaK in native protein folding. PLoS Genet. 2014 Jul 24;10(7):e1004516.

Hitesh Bhattarai, Richa Gupta, Michael S. Glickman. DNA Ligase C1 mediates the LigD independent NHEJ pathway of Mycobacterium smegmatis. J Bacteriol. 2014 Oct 1; 196(19):3366-76.  Epub 2014 Jun 23.

  • Commentary: Matthews LA, Simmons LA. Bacterial Non-Homologous End Joining Requires Teamwork. J Bacteriol. 2014 Jul 21

Kendra K. Harris, Allison Fay, Han Yan, Pratima Kunwar, Nicholas Socci, Narender Pottabathini, Ramakrishna R. Juventhala, Hakim Djaballah, and Michael S. Glickman. A Novel Imidazoline Antimicrobial Scaffold that inhibits DNA replication with Activity Against Mycobacteria and Drug Resistant Gram-Positive Cocci. ACS Chem Biology,2014 Sep 15. [Epub ahead of print].

58.  Ryzhikov M, Gupta R, Glickman M, Korolev S. RecO Protein Initiates DNA Recombination and Strand Annealing through Two Alternative DNA Binding  Mechanisms. J Biol Chem. 2014 Oct 17;289(42):28846-55. Epub 2014 Aug 28.

Books, Book Chapters, and Reviews

Glickman, M.S. and Goldberg, M.B. 1998. Epidemiology and Microbiology of Shigella Gastroenteritis. In: Rose B.D., editor. UpToDate Medicine (serial on CD ROM), Wellesley.

Glickman, M.S., and Jacobs, W.R., Jr. 2001. Microbial pathogenesis of Mycobacterium tuberculosis: dawn of a discipline. Cell 104:477-485.

Glickman, M.S., and Pamer, E.G. 2004.Cell Mediated Immunity to Infection. In: Mandell et al. Principles and Practice of Infectious Diseases. Churchill Livingstone.

Makinoshima, H., and Glickman, M.S. 2006. Site-2 proteases in prokaryotes: regulated intramembrane proteolysis expands to microbial pathogenesis. Microbes Infect 8:1882-1888.

Glickman, M.S. 2007. Cording, Cord factors, and Trehalose Dimycolate. In: Daffé, M. and Reyrat, J.M., editors. The Mycobacterial Cell Envelope. ASM Press.

Shuman, S., and Glickman, M.S. 2007. Bacterial DNA repair by non-homologous end joining. Nat Rev Microbiol 5: 852-861.

Stallings, C. and Glickman, M.S. 2010. Is Mycobacterium tuberculosis stressed out? A critical assessment of the genetic evidence. Microbes Infect. 12:1091-101. Epub 2010 Aug 5.

Glickman, M.S. 2010. Mycobacterium tuberculosis Infection in Cancer Patients. In: Amar Safdar, MD, editor. Management of Infections in Cancer Patients. Humana Press.

Stallings, C. and Glickman, M.S. 2011. CarD- A New RNA Polymerase Modulator in Mycobacteria. Transcr. 2:15-18. Epub 2010 Sep 14.

Glickman M.S. 2014. Double Strand DNA break repair in Mycobacteria. In Molecular Genetics of Mycobacteria, ASM Press.