The pervasive influence of the immune system on human health and disease underscores the importance of mechanistic understanding of immune regulation under pathophysiological conditions. Modern immunology is built on the foundation of clonal selection and pattern recognition theories that emphasize innate and adaptive immune recognition in controlling immune responses.


Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. Peng M, Yin N, Li MO. Cell.2014 Sep 25;159(1):122-33.

The cellular and molecular origin of tumor-associated macrophages. Franklin RA, Liao W, Sarkar A, Kim MV, Bivona MR, Liu K, Pamer EG, Li MO. Science. 2014 May 23;344(6186):921-5.

The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection. Kim MV, Ouyang W, Liao W, Zhang MQ, Li MO. Immunity.2013 Aug 22;39(2):286-97.

Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Ouyang W, Liao W, Luo CT, Yin N, Huse M, Kim MV, Peng M, Chan P, Ma Q, Mo Y, Meijer D, Zhao K, Rudensky AY, Atwal G, Zhang MQ, Li MO. Nature. 2012 Nov 7;491(7425):554-9.

T cell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-β1 cytokine. Donkor MK, Sarkar A, Savage PA, Franklin RA, Johnson LK, Jungbluth AA, Allison JP, Li MO. Immunity. 2011 Jul 22;35(1):123-34.

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Selected Achievements

Scholar, Leukemia and Lymphoma Society (2014)

Louise and Allston Boyer Young Investigator Award for Basic Research (2012)

Scholar, American Cancer Society (2012)

Scholar, Rita Allen Foundation (2008)

Hulda Irene Duggan Arthritis Investigator (2007)

Ming Li

At Work: Immunologist Ming Li

Immunologist Ming Li hopes to uncover insights that would allow scientists to harness the power of the immune system for cancer therapy.