Morgan Huse: Publications

Le Floc’h, A. Tanaka, Y., Bantilan, N. S., Voisinne, G., Altan-Bonnet, G., Fukui, Y., and Huse, M. (2013). Annular PIP3 Accumulation Controls Actin Architecture and Modulates Cytotoxicity at the Immunological Synapse. J. Exp. Med. 210, 2721-2737.

Huse, M., Le Floc’h, A., and Liu, X. (2013). From Lipid Second-Messengers to Molecular Motors: Microtubule-Organizing Center Reorientation in T Cells. Immunol. Rev. 256, 95-106. 

Liu, X., Kapoor, T. M., Chen, J. K., and Huse, M. (2013). Diacylglycerol Promotes Centrosome Polarization in T Cells via Reciprocal Localization of Dynein and Myosin II. Proc. Nat. Acad. Sci. USA 110, 11976-11981. 

Gasteiger, G., Hemmers, S., Firth, M. A., Le Floc’h, A., Huse, M., Sun, J. C., and Rudensky, A. Y. (2013). IL-2-dependent Tuning of NK Cell Sensitivity for Target Cells is Controlled by Regulatory T Cells. J. Exp. Med. 210, 1167-1178. 

Pittari G., Liu X. R., Selvakumar A., Zhao Z., Merino E., Huse M., Chewning J. H., Hsu K. C., and Dupont B. (2013). NK Cell Tolerance of Self-Specific Activating Receptor KIR2DS1 in Individuals with Cognate HLA-C2 Ligand. J. Immunol. 190, 4650-4660. 

Huse, M., Milanoski, S. C., and Abeyweera, T. P. (2013). Building Tolerance by Dismantling Synapses: Inhibitory Receptor Signaling in Natural Killer Cells.  Immunol. Rev. 251, 143-153. 

Ouyang, W., Liao, W., Luo, C.T., Yin, N., Huse, M., Kim, M.V., Peng, M., Chan, P., Ma, Q., Mo, Y., Meijer, D., Zhao, K., Rudensky, A.Y., Atwal, G., Zhang, M.Q., and Li, M.O. (2012). Novel Foxo1-dependent Transcriptional Programs Control T(reg) Cell Function. Nature, 491, 554-559.

Merino, E., Abeyweera, T. P., Firth, M. A., Zawislak, C. L., Basu, R., Liu, X., Sun, J. C., and Huse, M. (2012). Protein Kinase C-q Clustering at Immunological Synapses Amplifies Effector Responses in Natural Killer Cells. J. Immunol. 189, 4859-4869.

Huse, M. (2012). Microtubule-Organizing Center Polarity and the Immunological Synapse: Protein Kinase C and Beyond.  Front. Immunol. 3, 235.

Quann, E. J., Liu, X., Altan-Bonnet, G., and Huse, M. (2011). A Cascade of Protein Kinase C Isozymes Promotes Cytoskeletal Polarization in T Cells. Nat. Immunol. 12, 647-654

Huse, M. (2011). Lymphocyte Polarity, the Immunological Synapse and the Scope of Biological Analogy.  Bioarchitecture 1, 180-185.

Abeyweera, T. P., Merino, E., and Huse, M. (2011) Inhibitory Signaling Blocks Activating Receptor Clustering and Induces Cytoskeletal Retraction in Natural Killer Cells. J. Cell Biol. 192, 675-690.

Huse, M. (2010). Photochemical Approaches to T-cell Activation. Immunol. 130, 151-157.

Kuhns, M. S., Girvin, A. T., Klein, L. O., Chen, R., Jensen, K. D. C., Newell, E. W., Huppa, J. B., Lillemeier, B. F., Huse, M., Chien, Y., Garcia, K. C., and Davis, M. M. (2010). Evidence for a Functional Sidedness to the alphabetaTCR. Proc. Nat. Acad. Sci. USA 107, 5094-5099.

Quann, E. J., Merino, E., Furuta, T., and Huse, M. (2009). Localized Diacylglycerol Drives the Polarization of the Microtubule-Organizing Center in T cells. Nat. Immunol. 10, 627-635.

Huse, M. (2009). The T-cell-receptor Signaling Network. J. Cell. Sci. 122, 1269-1273.

Huse, M., Quann, E. J., and Davis, M. M. (2008). Shouts, Whispers, and the Kiss of Death: Directional Secretion in T cells. Nat. Immunol. 9, 1105-1111.

Huse, M.*, Klein, L. O.*, Girvin, A. T., Faraj, J. M., Li, Q., Kuhns, M. S., and Davis, M. M. (2007). Spatial and Temporal Dynamics of T Cell Receptor Signaling with a Photocaged Agonist. Immunity, 27, 76-88 *equal contribution

Davis, M. M., Krogsgaard, M., Huse, M., Huppa, J., Lillemeier, B. F., and Li, Q.-J. (2007). T Cells as a Self-Referential, Sensory Organ. Annu. Rev. Immunol. 25, 681-695

Huse, M., Lillemeier, B. F., Kuhns, M. S., Chen, D. S., and Davis, M. M. (2006). T Cells Use Two Directionally Distinct Pathways for Cytokine Secretion. Nat. Immunol. 7, 247-255.

Krogsgaard, M., Li, Q.-J., Sumen, C., Huppa, J. B., Huse, M., and Davis, M. M. (2005). Agonist/Self Peptide-MHC Heterodimers Drive T Cell Activation and Sensitivity. Nature 434, 238-243

Ottesen J. J., Huse, M., Sekedat, M. D., and Muir, T. W. (2004). Semisynthesis of Phosphovariants of Smad2 Reveals a Substrate Preference for the Activated TbetaR-I Kinase. Biochemistry 43, 5698-5706.

Huse, M. and Kuriyan, J. (2002). The Conformational Plasticity of Protein Kinases. Cell 109, 275-282.

Huse, M. (2002). Structural Biology: Alive and Skiing. Structure 10, 137-138.

Flavell, R. R., Huse, M., Goger, M., Trester-Zedlitz, M., Kuriyan, J., and Muir, T. W. (2002). Efficient Semi-synthesis of a Tetraphosphorylated Analog of the Type I TGF-beta Receptor. Org. Lett.4,165-168.

Wu, J.-W., Hu, M., Chai, J., Seoane, J., Huse, M., Li, C., Rigotti, D. J., Kyin, S., Muir, T. W., Fairman, R., Massagué, J., and Shi, Y. (2001). Crystal Structure of Phosphorylated Smad2: Recognition of Phosphoserine by the MH2 Domain and Insights on Smad Function in TGF-beta Signaling. Mol. Cell 8, 1277-1289.

Huse, M., Muir, T. W., Xu, L., Chen, Y.-G., Kuriyan, J., and Massagué, J. (2001). The TGF-beta Receptor Activation Process: An Inhibitor- to Substrate-binding Switch. Mol. Cell 8, 671-682.

Huse, M., Holford, M. N., Kuriyan J., and Muir, T. W. (2000). Semi-synthesis of Hyperphosphorylated Type I TGF-beta Receptor: Addressing the Mechanism of Kinase Activation. J. Am. Chem Soc. 122, 8337-8338

Huse, M., Chen, Y. G., Massagué, J., and Kuriyan, J. (1999). Crystal Structure of the Cytoplasmic Domain of the Type I TGF-beta Receptor in Complex with FKBP12. Cell 96, 425-436.

Huse, M., Eck, M. J., and Harrison, S. C. (1998). A Zn2+ Ion Links the Cytoplasmic Tail of CD4 to the N-terminal region of Lck. J. Biol. Chem. 273, 18729-18733.

Moarefi, I., LaFevre-Bernt, M., Sicheri, F., Huse, M., Lee, C.-H., Kuriyan, J., and Miller, W. T. (1997). Activation of the Src-family Tyrosine Kinase Hck by SH3 Domain Displacement. Nature 385, 650-653.