Sloan-Kettering Institute // Immunology Program

Morgan Huse: Publications

Ouyang, W., Liao, W., Luo, C.T., Yin, N., Huse, M., Kim, M.V., Peng, M., Chan, P., Ma, Q., Mo, Y., Meijer, D., Zhao, K., Rudensky, A.Y., Atwal, G., Zhang, M.Q., and Li, M.O. (2012). Novel Foxo1-dependent Transcriptional Programs Control T(reg) Cell Function. Nature, 491, 554-559.

Merino, E., Abeyweera, T. P., Firth, M. A., Zawislak, C. L., Basu, R., Liu, X., Sun, J. C., and Huse, M. (2012). Protein Kinase C-q Clustering at Immunological Synapses Amplifies Effector Responses in Natural Killer Cells. J. Immunol. 189, 4859-4869.

Huse, M. (2012). Microtubule-Organizing Center Polarity and the Immunological Synapse: Protein Kinase C and Beyond.  Front. Immunol. 3, 235.

Quann, E. J., Liu, X., Altan-Bonnet, G., and Huse, M. (2011). A Cascade of Protein Kinase C Isozymes Promotes Cytoskeletal Polarization in T Cells. Nat. Immunol. 12, 647-654

Huse, M. (2011). Lymphocyte Polarity, the Immunological Synapse and the Scope of Biological Analogy.  Bioarchitecture 1, 180-185.

Abeyweera, T. P., Merino, E., and Huse, M. (2011) Inhibitory Signaling Blocks Activating Receptor Clustering and Induces Cytoskeletal Retraction in Natural Killer Cells. J. Cell Biol. 192, 675-690.

Huse, M. (2010). Photochemical Approaches to T-cell Activation. Immunol. 130, 151-157.

Kuhns, M. S., Girvin, A. T., Klein, L. O., Chen, R., Jensen, K. D. C., Newell, E. W., Huppa, J. B., Lillemeier, B. F., Huse, M., Chien, Y., Garcia, K. C., and Davis, M. M. (2010). Evidence for a Functional Sidedness to the alphabetaTCR. Proc. Nat. Acad. Sci. USA 107, 5094-5099.

Quann, E. J., Merino, E., Furuta, T., and Huse, M. (2009). Localized Diacylglycerol Drives the Polarization of the Microtubule-Organizing Center in T cells. Nat. Immunol. 10, 627-635.

Huse, M. (2009). The T-cell-receptor Signaling Network. J. Cell. Sci. 122, 1269-1273.

Huse, M., Quann, E. J., and Davis, M. M. (2008). Shouts, Whispers, and the Kiss of Death: Directional Secretion in T cells. Nat. Immunol. 9, 1105-1111.

Huse, M.*, Klein, L. O.*, Girvin, A. T., Faraj, J. M., Li, Q., Kuhns, M. S., and Davis, M. M. (2007). Spatial and Temporal Dynamics of T Cell Receptor Signaling with a Photocaged Agonist. Immunity, 27, 76-88 *equal contribution

Davis, M. M., Krogsgaard, M., Huse, M., Huppa, J., Lillemeier, B. F., and Li, Q.-J. (2007). T Cells as a Self-Referential, Sensory Organ. Annu. Rev. Immunol. 25, 681-695

Huse, M., Lillemeier, B. F., Kuhns, M. S., Chen, D. S., and Davis, M. M. (2006). T Cells Use Two Directionally Distinct Pathways for Cytokine Secretion. Nat. Immunol. 7, 247-255.

Krogsgaard, M., Li, Q.-J., Sumen, C., Huppa, J. B., Huse, M., and Davis, M. M. (2005). Agonist/Self Peptide-MHC Heterodimers Drive T Cell Activation and Sensitivity. Nature 434, 238-243

Ottesen J. J., Huse, M., Sekedat, M. D., and Muir, T. W. (2004). Semisynthesis of Phosphovariants of Smad2 Reveals a Substrate Preference for the Activated TbetaR-I Kinase. Biochemistry 43, 5698-5706.

Huse, M. and Kuriyan, J. (2002). The Conformational Plasticity of Protein Kinases. Cell 109, 275-282.

Huse, M. (2002). Structural Biology: Alive and Skiing. Structure 10, 137-138.

Flavell, R. R., Huse, M., Goger, M., Trester-Zedlitz, M., Kuriyan, J., and Muir, T. W. (2002). Efficient Semi-synthesis of a Tetraphosphorylated Analog of the Type I TGF-beta Receptor. Org. Lett.4,165-168.

Wu, J.-W., Hu, M., Chai, J., Seoane, J., Huse, M., Li, C., Rigotti, D. J., Kyin, S., Muir, T. W., Fairman, R., Massagué, J., and Shi, Y. (2001). Crystal Structure of Phosphorylated Smad2: Recognition of Phosphoserine by the MH2 Domain and Insights on Smad Function in TGF-beta Signaling. Mol. Cell 8, 1277-1289.

Huse, M., Muir, T. W., Xu, L., Chen, Y.-G., Kuriyan, J., and Massagué, J. (2001). The TGF-beta Receptor Activation Process: An Inhibitor- to Substrate-binding Switch. Mol. Cell 8, 671-682.

Huse, M., Holford, M. N., Kuriyan J., and Muir, T. W. (2000). Semi-synthesis of Hyperphosphorylated Type I TGF-beta Receptor: Addressing the Mechanism of Kinase Activation. J. Am. Chem Soc. 122, 8337-8338

Huse, M., Chen, Y. G., Massagué, J., and Kuriyan, J. (1999). Crystal Structure of the Cytoplasmic Domain of the Type I TGF-beta Receptor in Complex with FKBP12. Cell 96, 425-436.

Huse, M., Eck, M. J., and Harrison, S. C. (1998). A Zn2+ Ion Links the Cytoplasmic Tail of CD4 to the N-terminal region of Lck. J. Biol. Chem. 273, 18729-18733.

Moarefi, I., LaFevre-Bernt, M., Sicheri, F., Huse, M., Lee, C.-H., Kuriyan, J., and Miller, W. T. (1997). Activation of the Src-family Tyrosine Kinase Hck by SH3 Domain Displacement. Nature 385, 650-653.