I am actively involved in research on radionuclide-based methods for detecting and localizing tumor hypoxia, immune effector-cell trafficking, patient-specific dosimetry for radionuclide therapies, and small-animal and molecular imaging.  My research employs state-of-the-art in vivo imaging technologies for noninvasively detecting, localizing, and biologically characterizing primary and metastatic cancer cells in patients. In addition, we apply in vivo small-animal (rodent) models of human cancer using high-resolution, quantitative imaging modalities such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT) of radiolabeled tracers (molecular imaging), computed tomography (CT), optical imaging of luminescent and fluorescent probes, and structural and functional ultrasound scanning.