Christos Colovos

Research Fellow (2009 - 2012)

Awards and Scholarships

2011 Society of Thoracic Surgeons’ “Look to the Future” Scholarship

Current Employment

Surgical Resident, Cedar Sinai Medical Center, Los Angles, CA

Publications by Christos Colovos

Manuscripts

Schuchert MJ, Adusumilli PS, Cook CC, Colovos C, Kilic A, Nason KS, Landreneau JP, Zikos T, Jack R, Luketich JD, Landreneau RJ. The impact of scoliosis among patients undergoing repair of giant paraesophageal hernia. J Gastrointest Surg 2011 Jan;15(1):23-8. PMID 20824386

Servais EL, Colovos C, White J, Bograd AJ, Sadelain M, Adusumilli PS. Animal models and molecular imaging tools to investigate lymph node metastases. J Mol Med 2011 Aug;89(8):753-69. PMID 21556810

Servais EL, Colovos C, Kachala S, Adusumilli PS. Pre-clinical mouse models of primary and metastatic pleural cancers of the lung and breast and the use of bioluminescent imaging to monitor pleural tumor burden. Curr Protoc Pharmacol 2011 Sep;Chapter 14:Unit14.21. PMID 21898334

Kadota K, Suzuki K, Colovos C, Sima CS, Rusch VW, Travis WD, Adusumilli PS. A nuclear grading system is a strong predictor of survival in epitheloid diffuse malignant pleural mesothelioma. Mod Pathology 2012 Feb;25(2):260-71. PMID 21983936

Bograd A, Suzuki K, Vertes E, Colovos C, Morales E, Sadelain M, Adusumilli PS. Immune responses and immunotherapeutic interventions in malignant pleural mesothelioma. Cancer Immunol Immunother 2011 Nov;60(11):1509-27. PMID 21913025

Servais EL, Suzuki K, Colovos C, Rodriguez L, Sima C, Fleischer M, Rusch VW, Sadelain M, Adusumilli PS. An in vivo platform for tumor biomarker assessment. PLoS One 2011;6(10):e26722. PMID 22046338

Servais EL, Colovos C, Rodriguez LA, Bograd AJ, Nitadori JI, Sima CS, Rusch VW, Sadelain M, Adusumilli PS. Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 secretion in an orthotopic mouse model and in epithelioid pleural mesothelioma patients. Clin Cancer Res 2012;18(9):2478-89. PMID 22371455

Kadota K, Colovos C, Suzuki K, Rizk NP, Dunphy MP, Zabor EC, Sima CS, Yoshizawa A, Travis WD, Rusch VW, Adusumilli PS. FDG-PET SUVmax combined with IASLC/ATS/ERS histologic classification improves the prognostic stratification of patients with stage I lung adenocarcinoma. Ann Surg Oncol 2012; 19(11):3598-605. PMID 22644511

Colovos C, Villena-Vargas J, Sadelain M, Adusumilli PS. Safety and stability of retrovirally transduced chimeric antigen receptor T cells. Immunotherapy 2012 Sep;4(9):899-902. PMID 23046233

Nitadori J, Colovos C, Kadota K, Sima CS, Sarkaria I, Rizk N, Rusch VW, Travis WD, Adusumilli PS. Visceral Pleural Invasion Does Not Affect Recurrence or Overall Survival among Patients with Lung Adenocarcinoma ≤2 cm: A Proposal to Reclassify T1 Lung Adenocarcinoma. Chest 2013; Jun 27. [Epub ahead of print] PubMed PMID 23807749

Abstracts/Presentations

Villena-Vargas J, Cherkassky L, Colovos C, Servais E, Rodriguez L, Rusch VW, Sadelain M, Adusumilli PS. Critical role of CD28 costimulation in tumor-targeted T-cell therapy clinical trial for pleural malignancies. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia.

Bograd A, Villena-Vargas J, Kachala S, Servais E, Colovos C, Rodriguez L, Rusch VW, Sadelain M, Adusumilli PS. Mesothelin-targeted T-cell therapy optimized for the lung adenocarcinoma tumor microenvironment. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia.

Nitadori J, Colovos C, Kadota K, Sima CS, Rusch VW, Travis WD, Adusumilli PS. Visceral pleural invasion does not impact on recurrence-free or overall survival in lung adenocarcinoma ≤ 2 cm. Chicago Multidisciplinary Symposium in Thoracic Oncology, September 2012, Chicago, IL.

Servais EL, Colovos C, Rodriguez L, Bograd AJ, Nitadori J, Sima C, Sadelain M, Rusch VW, Adusumilli PS. Mesothelin promotes mesothelioma cell invasion and MMP-9 secretion in an orthotopic mouse model and in malignant pleural mesothelioma (MPM) patients: a potential mechanism for MPM regional aggressiveness. American Association for Thoracic Surgery 2012, Lillehei Forum, May 2012, San Francisco, CA.

Colovos C, Rizk NP, Singh N, Bains M, Bikson M, Rusch VW, Adusumilli PS. Real-time intraoperative tissue oxygenation monitoring by wireless pulse oximetry (WiPOX) to assess gastric conduit oxygenation during esophagogastrectomy: a prospective feasibility study. 2011 American College of Surgeons 97th Annual Clinical Congress, October 23-27, 2011, San Francisco, CA (session SF28).

Colovos C, Bograd AJ, Cavnar MJ, Rodriguez L, Rusch VW, Sadelain M, Adusumilli PS. An Immunocompetent orthotopic mouse model of malignant pleural mesothelioma permits pleural tumor immune microenvironment characterization and intrapleural interleukin-12 therapy. International Association for the Study of Lung Cancer (IASLC) 14th World Conference on Lung Cancer, July 2-5, 2011, Amsterdam, The Netherlands.

Servais EL, Suzuki K, Fleisher M, Sima C, Colovos C, Rodriguez L, Rusch VW, Sadelain M, Adusumilli PS. An in vivo platform for biomarker validation in malignant pleural mesothelioma. 10th International Conference of the International Mesothelioma Interest Group (IMIG), August 31-September 3, 2010, Kyoto, Japan.

Servais EL, Colovos C, Kachala SS, Rodriguez L, Kadota K, Rusch VW, Sadelain M, Adusumilli PS. Mesothelin expression promotes invasive phenotype and matrix metalloproteinase secretion in pleural mesothelioma. 10th International Conference of the International Mesothelioma Interest Group (IMIG), August 31-September 3, 2010, Kyoto, Japan.

Servais EL, Colovos C, Rodriguez L, Velez MC, Rusch VW, Sadelain M, Adusumilli PS. Location matters: biological significance of pleural microenvironment in mesothelioma murine models. 10th International Conference of the International Mesothelioma Interest Group (IMIG), August 31-September 3, 2010, Kyoto, Japan.

Servais EL, Colovos C, Suzuki K, Velez M, Rodriguez L, Sima C, Rusch VW, Sadelain M, Adusumilli PS. Mesothelin is a biomarker of tumor aggressiveness and therapy response in malignant pleural mesothelioma (MPM). Oral presentation in surgical forum: American College of Surgeons 96th Annual Clinical Congress, October 3-7, 2010, Washington, DC.

Colovos C, Servais EL, Kachala SK, Rodriguez L, Kadota K, Rusch VW, Sadelain M, Adusumilli PS. Significance of tumor microenvironment in preclinical investigation of malignant pleural mesothelioma. International Symposium on Malignant Mesothelioma, June 10-12, 2010, Washington, DC.

Colovos C, Servais EL, Kachala SK, Rodriguez L, Kadota K, Rusch VW, Sadelain M, Adusumilli PS. Significance of tumor microenvironment in preclinical investigation of malignant pleural mesothelioma. International Symposium on Malignant Mesothelioma, June 10-12, 2010, Washington, DC.