Elliot Servais

Research Fellow (2008 - 2010)

Awards and Scholarships

2010 Society of Thoracic Surgeons “Look to the Future” Scholarship, Baker Street Foundation Research Award, C. Walton Lillehei Resident Forum (AATS) Finalist

Current Employment

Thoracic Surgery Research Fellow, Brigham and Women’s Hospital, Boston, MA

Publications by Elliot Servais

Manuscripts: 

Kachala SS, Bograd AJ, Villena-Vargas J, Suzuki K, Servais EL, Kadota K, Chou J, Sima CS, Vertes E, Rusch VW, Travis WD, Sadelain M, Adusumilli PS. Mesothelin Overexpression Is a Marker of Tumor Aggressiveness and Is Associated with Reduced Recurrence-free and Overall Survival in Early-Stage Lung Adenocarcinoma. Clin Cancer Res. 2014 Feb 15;20(4):1020-8.

Kachala SS, Servais ES, Park BJ, Rusch VW, Adusumilli PS. Therapeutic sentinel lymph node imaging. Semin Thor Cardiovasc Surg 2009;21(4):327-38. PMID 20226346

Servais EL, Rizk NP, Oliveira L, Rusch VW, Bikson M, Adusumilli PS. Real-time intraoperative detection of tissue hypoxia in gastrointestinal surgery by wireless pulse oximetry. Surg Endosc 2011 May;25(5):1383-9. PMID 20972585

Suzuki K, Servais EL, Rizk NP, Solomon SB, Sima CS, Park BJ, Kachala SS, Zlobinsky M, Rusch VW, Adusumilli PS. Palliation and pleurodesis in malignant pleural effusion: the role for tunneled pleural catheters. J Thorac Oncol. 2011 Apr;6(4):762-7. PMID 21325982

Servais EL, Colovos C, White J, Bograd AJ, Sadelain M, Adusumilli PS*. Animal models and molecular imaging tools to investigate lymph node metastases. J Mol Med 2011 Aug;89(8):753-69. PMID 21556810

Servais EL, Colovos C, Kachala S, Adusumilli PS. Pre-clinical mouse models of primary and metastatic pleural cancers of the lung and breast and the use of bioluminescent imaging to monitor pleural tumor burden. Curr Protoc Pharmacol 2011 Sep;Chapter 14:Unit14.21. PMID 21898334

Servais EL, Suzuki K, Colovos C, Rodriguez L, Sima C, Fleischer M, Rusch VW, Sadelain M, Adusumilli PS*. An in vivo platform for tumor biomarker assessment. PLoS One 2011;6(10):e26722. PMID 22046338

Rizk NP, Servais EL, Tang LH, Sima CS, Gerdes H, Fleisher M, Rusch VW, Adusumilli PS*. Tissue and serum mesothelin are potential markers of neoplastic progression in Barrett’s associated esophageal adenocarcinoma. Cancer Epidemiol Biomarkers Prev 2012 Mar;21(3):482-6. PMID 22237988

Servais EL, Colovos C, Rodriguez LA, Bograd AJ, Nitadori JI, Sima CS, Rusch VW, Sadelain M, Adusumilli PS*. Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 secretion in an orthotopic mouse model and in epithelioid pleural mesothelioma patients. Clin Cancer Res 2012;18(9):2478-89. PMID 22371455

Kachala SS, Bograd AJ, Villena-Vargas J, Suzuki K, Servais EL, Kadota K, Chou J, Sima CS, Vertes E, Rusch VW, Travis WD, Sadelain M, Adusumilli PS. Mesothelin Overexpression Is a Marker of Tumor Aggressiveness and Is Associated with Reduced Recurrence-free and Overall Survival in Early-Stage Lung Adenocarcinoma. Clin Cancer Res 2014 (in press) Abstracts/Presentations –

Villena-Vargas J, Cherkassky L, Colovos C, Servais E, Rodriguez L, Rusch VW, Sadelain M, Adusumilli PS. Critical role of CD28 costimulation in tumor-targeted T-cell therapy clinical trial for pleural malignancies. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia.

Bograd A, Villena-Vargas J, Kachala S, Servais E, Colovos C, Rodriguez L, Rusch VW, Sadelain M, Adusumilli PS. Mesothelin-targeted T-cell therapy optimized for the lung adenocarcinoma tumor microenvironment. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia.

 

Kachala S, Bograd AJ, Rodriguez L, Servais EL, Kadota K, Sima C, Rusch VW, Travis WD, Sadelain M, Adusumilli PS. Mesothelin decreases recurrence-free survival in lung adenocarcinoma by imparting an aggressive phenotype. American Association for Thoracic Surgery meeting. May 4-8, 2013; Minneapolis. MN (Oral Presentation).

Servais EL, Colovos C, Rodriguez L, Bograd AJ, Nitadori J, Sima C, Sadelain M, Rusch VW, Adusumilli PS. Mesothelin promotes mesothelioma cell invasion and MMP-9 secretion in an orthotopic mouse model and in malignant pleural mesothelioma (MPM) patients: a potential mechanism for MPM regional aggressiveness. American Association for Thoracic Surgery 2012, Lillehei Forum, May 2012, San Francisco, CA.

Servais EL, Nitadori J, Morales EA, Suzuki K, Bograd AJ, Rizk NP, Downey RJ, Rusch VW, Adusumilli PS. Pre-operative consolidation to tumor ratio on computed tomography and FDG-PET SUVmax predict recurrence after limited resection of early lung adenocarcinoma. American Association for Thoracic Surgery 2012, May 2012, San Francisco, CA.

Servais EL, Suzuki K, Fleisher M, Sima C, Colovos C, Rodriguez L, Rusch VW, Sadelain M, Adusumilli PS. An in vivo platform for biomarker validation in malignant pleural mesothelioma. 10th International Conference of the International Mesothelioma Interest Group (IMIG), August 31-September 3, 2010, Kyoto, Japan.

Servais EL, Colovos C, Kachala SS, Rodriguez L, Kadota K, Rusch VW, Sadelain M, Adusumilli PS. Mesothelin expression promotes invasive phenotype and matrix metalloproteinase secretion in pleural mesothelioma. 10th International Conference of the International Mesothelioma Interest Group (IMIG), August 31-September 3, 2010, Kyoto, Japan.

 

Servais EL, Colovos C, Rodriguez L, Velez MC, Rusch VW, Sadelain M, Adusumilli PS. Location matters: biological significance of pleural microenvironment in mesothelioma murine models. 10th International Conference of the International Mesothelioma Interest Group (IMIG), August 31-September 3, 2010, Kyoto, Japan.

Suzuki K, Servais EL, Sima C, Kachala SS, Rizk NP, Park B, Rusch VW, Adusumilli PS. Outcomes of indwelling tunneled pleural catheters for malignant pleural effusion: the role for surgical evaluation. Oral presentation in surgical forum: American College of Surgeons 96th Annual Clinical Congress, October 3-7, 2010, Washington, DC.

Servais EL, Colovos C, Suzuki K, Velez M, Rodriguez L, Sima C, Rusch VW, Sadelain M, Adusumilli PS. Mesothelin is a biomarker of tumor aggressiveness and therapy response in malignant pleural mesothelioma (MPM). Oral presentation in surgical forum: American College of Surgeons 96th Annual Clinical Congress, October 3-7, 2010, Washington, DC.

Colovos C, Servais EL, Kachala SK, Rodriguez L, Kadota K, Rusch VW, Sadelain M, Adusumilli PS. Significance of tumor microenvironment in preclinical investigation of malignant pleural mesothelioma. International Symposium on Malignant Mesothelioma, June 10-12, 2010, Washington, DC.

Rodriguez L, Colovos C, , Rusch VW, Sadelain M, Adusumilli PS. WT-1 targeted immunotherapy for malignant pleural mesothelioma. International Symposium on Malignant Mesothelioma, June 10-12, 2010, Washington, DC.

Servais EL, Colovos C, Suzuki K, Rodriguez L, Sima C, Rusch VW, Sadelain M, Adusumilli PS. Biomarker validation for a rare malignancy in a mouse model. AACR 100th Annual Meeting, April 17-20, 2010, Washington, DC.

Servais EL, Rizk NP, Oliviera L, Bikson M, Rusch VW, Adusumilli PS. Real-time intraoperative detection of tissue hypoxia in endoscopic gastrointestinal surgery by a novel wireless pulse oximeter (WiPOX). (Abstract #27033, SS04, Basic Science Session) 12th World Congress of Endoscopic Surgery, SAGES, Society of American Gastrointestinal and Endoscopic Surgery, April 14-17, 2010, Washington, DC.

Servais EL, Velez MC, Rusch VW, Sadelain M, Adusumilli PS. A preclinical mouse model of orthotopic pleural cancer that facilitates noninvasive quantitative monitoring of tumor progression and therapy response. Cancer Res 2009;69(23 Suppl):B27.

Oliveira L, Servais E, Rizk N, Adusumilli P, Bikson M. Intra-operative pulse oximetry. J Med Devices 2009;3(2):027533.

Oliveira L,Servais E, Rizk N, Adusumilli P, Bikson M. Intra-operative pulse oximetry. 8th Annual Design of Medical Devices Conference, April 14-16, 2009, Minneapolis, MN.