Prasad Jallepalli: Publications

Selected References

Paschal CR, Maciejowski J, Jallepalli PV. (2012). A stringent requirement for Plk1 T210 phosphorylation during K-fiber assembly and chromosome congression. Chromosoma. May;9.

Burkard ME, Santamaria A, Jallepalli PV. (2012). Enabling and disabling polo-like kinase 1 inhibition through chemical genetics. ACS Chem Biol. Jun;15 7(6):978-81.

Oppermann FS, Grundner-Culemann K, Kumar C, Gruss OJ, Jallepalli PV, Daub H. (2012). Combination of chemical genetics and phosphoproteomics for kinase signaling analysis enables confident identification of cellular downstream targets. Mol Cell Proteomics. Apr;11(4):O111.012351.

Sherwood R, Takahashi TS, Jallepalli PV. (2010). Sister acts: coordinating DNA replication and cohesion establishment. Genes Dev. Dec 15;24(24):2723-31.

Burkard ME, Jallepalli PV. (2010). Validating cancer drug targets through chemical genetics. Biochim Biophys Acta. Dec;1806(2):251-7.

Maciejowski J, George KA, Terret ME, Zhang C, Shokat KM, Jallepalli PV. (2010). Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J Cell Biol. Jul 12;190(1):89-100.

Mocciaro A, Berdougo E, Zeng K, Black E, Vagnarelli P, Earnshaw W, Gillespie D, Jallepalli P, Schiebel E. (2010). Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair. J Cell Biol. May 17;189(4):631-9.

Terret ME, Sherwood R, Rahman S, Qin J, Jallepalli PV. Cohesin acetylation speeds the replication fork. Nature. 2009; 462: 231-234.

Ciccia A, Bredemeyer AL, Sowa ME, Terret ME, Jallepalli PV, Harper JW, Elledge SJ. The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart. Genes Dev. 2009; 23: 2415-25.

Tsou MF, Wang WJ, George KA, Uryu K, Stearns T, Jallepalli PV. Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells. Dev Cell. 2009; 17: 344-354

Berdougo E, Terret ME, Jallepalli PV. Functional Dissection of mitotic regulators through gene targeting in human somatic cells. Methods Mol Biol. 2009; 545: 21-37

Burkard ME, Maciejowski J, Rodrigues-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat KM, Carr SA, Yaffe MB, Jallepalli PV. Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PloS Biol. 2009;7: e1000111.

Berdougo E, Nachury MV, Jackson PK, Jallepalli PV. The nucleolar phosphatase Cdc14B is dispensable for chromosome segregation and mitotic exit in human cells. Cell Cycle. 2008; 7: 1184-90

P.V. Jallepalli and D. Pellman. Aneuploidy in the balance. Science. 2007; 317: 904-905.

C. L. Randall, M.E. Burkard, and P.V. Jallepalli. Polo kinase and cytokinesis: harnessing the awesome power of chemical genetics. Cell Cycle. 2007; 6: 1713-1717.

M.E. Burkard, C.L. Randall, S. Larochelle, C. Zhang, K.M. Shokat, R.P. Fisher, and P.V. Jallepalli. Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. Proc Natl Acad Sci USA. 2007; 104: 4383-4388.

S. Larochelle, K.A. Merrick, M.-E. Terret, L. Wohlbold, N.M. Barboza, C. Zhang, K.M. Shokat, P.V. Jallepalli, and R.P. Fisher. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Molecular Cell. 2007; 25: 839-850.

M.-E. Terret and P.V. Jallepalli. Meiosis: separase strikes twice. Nature Cell Biology. 2005; 8: 910-911.

M. Papi, E. Berdougo, C.L. Randall, S. Ganguly, and P.V. Jallepalli. Multiple roles for separase auto-cleavage during the G2/M transition. Nature Cell Biology. 2005; 7: 1029-1035.

S. Spinette, C. Lengauer, J.A. Mahoney, P.V. Jallepalli, Z. Wang, L. Casciola-Rosen, and A. Rosen. Ufd2, a novel autoantigen in scleroderma, regulates sister chromatid separation. Cell Cycle. 2004; 3: 1638-1644.

Z. Wang, J.M. Cummins, D. Shen, D.P. Cahill, P.V. Jallepalli, T.L. Wang, D.W. Parsons, G. Traverso, M. Awad, N. Silliman, J. Ptak, S. Szabo, J.K. Willson, S.D. Markowitz, M.L. Goldberg, R. Karess, K. W. Kinzler, B. Vogelstein, V.E. Velculescu, and C. Lengauer. Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer Res. 2004; 64: 2998-3001.

H. Rajagopalan, P.V. Jallepalli, V.E. Velculescu, K.W. Kinzler, B. Vogelstein, and C. Lengauer. Inactivation of hCDC4 can cause chromosomal instability. Nature. 2004; 428: 77-81.

Jallepalli PV, Lengauer C, Vogelstein B, Bunz F. The Chk2 tumor suppressor is not required for p53 responses in human cancer cells. J Biol Chem. 2003; 278: 20475-20479.

Nowak MA, Komarova NL, Sengupta A, Jallepalli PV, Shih IeM, Vogelstein B, Lengauer C. The role of chromosomal instability in tumor initiation. Proc Natl Acad Sci USA. 2002; 99: 16226-16231.

Jallepalli PV, Lengauer C. Chromosome segregation and cancer: cutting through the mystery. Nat Rev Cancer. 2001; 1: 109-117.

Jallepalli PV, Waizenegger IC, Bunz F, Langer S, Speicher MR, Peters JM, Kinzler KW, Vogelstein B, Lengauer C. Securin is required for chromosomal stability in human cells. Cell. 2001; 105: 445-457.