Prasad Jallepalli: Publications

V. Rodriguez-Bravo, J. Maciejowski, J. Corona, H.K. Buch, M.T. Kanemaki, J.V. Shah, and P.V. Jallepalli.  Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor.  Cell 156, 1017-1031 (2014).

M.J. Jones and P.V. Jallepalli.  Chromothripsis: chromosomes in crisis.  Dev. Cell 23, 908-917 (2012).

C.R. Paschal, J. Maciejowski, and P.V. Jallepalli.  A stringent requirement for Plk1 T210 phosphorylation during K-fiber assembly and chromosome congression.  Chromosoma 121, 575-572 (2012).

M.E. Burkard, A. Santamaria, and P.V. Jallepalli.  Enabling and disabling Polo-like kinase 1 inhibition through chemical genetics.  ACS Chem Biol 7, 978-981 (2012).

F.S. Oppermann, K. Grundner-Culemann, C. Kumar, O.J. Gruss, P.V. Jallepalli, and H. Daub.  Combination of chemical genetics and phosphoproteomics for kinase signaling analysis enables confident identification of cellular downstream targets.  Mol Cell Proteomics 11, O111.012351 (2012).

R. Sherwood, T.S. Takahashi, and P.V. Jallepalli.  Sister acts: coordinating DNA replication and cohesion establishment.  Genes Dev. 24, 2723-2731 (2010).

J. Maciejowski, K.A. George, M.-E. Terret, C. Zhang, K.M. Shokat, and P.V. Jallepalli. Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.  J. Cell Biol. 190, 89-100 (2010).

A. Mocciaro, E. Berdougo, E. Black, P. Vagnarelli, W. Earnshaw, D. Gillespie, P. Jallepalli, and E. Schiebel.  Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired for DNA repair.  J. Cell Biol. 189, 631-639 (2010).

M.-E. Terret, R. Sherwood, S. Rahman, J. Qin, and P.V. Jallepalli.  Cohesin acetylation speeds the replication fork.  Nature 462, 231-234 (2009).

A. Ciccia, A.L. Bredemeyer, M.E. Sowa, M.-E. Terret, P.V. Jallepalli, J.W. Harper, and S.J. Elledge.  The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart.  Genes Dev. 23, 2415-2425 (2009).

M.-F.B. Tsou, W.J. Wang, K.A. George, K. Uryu, T. Stearns, and P.V. Jallepalli.  Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells.  Dev. Cell 17, 344-354 (2009).

M.E. Burkard, J. Maciejowski, V. Rodriguez-Bravo, M. Repka, D.M. Lowery, K.R. Clauser, C. Zhang, K.M. Shokat, S.A. Carr, M.B. Yaffe, and P.V. Jallepalli.  Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.  PLoS Biol. 7, e1000111 (2009).

E. Berdougo, M.-E. Terret, and P.V. Jallepalli.  Functional dissection of mitotic regulators through gene targeting in human somatic cells.  Methods Mol. Biol. 545, 21-37 (2009).

E. Berdougo, M.V. Nachury, P.K. Jackson, and P.V. Jallepalli.  The nucleolar phosphatase Cdc14B is dispensable for chromosome segregation and mitotic exit in human cells.  Cell Cycle 7, 1184-1190 (2008).

P.V. Jallepalli and D. Pellman.  Aneuploidy in the balance.  Science 317, 904-905 (2007).

C. L. Randall, M.E. Burkard, and P.V. Jallepalli.  Polo kinase and cytokinesis: harnessing the awesome power of chemical genetics.  Cell Cycle 6, 1713-1717 (2007).

M.E. Burkard, C.L. Randall, S. Larochelle, C. Zhang, K.M. Shokat, R.P. Fisher, and P.V. Jallepalli. Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells.  Proc. Natl. Acad. Sci. USA 104, 4383-4388 (2007).

S. Larochelle, K.A. Merrick, M.-E. Terret, L. Wohlbold, N.M. Barboza, C. Zhang, K.M. Shokat, P.V. Jallepalli, and R.P. Fisher.  Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.  Mol. Cell 25, 839-850 (2007).

M.-E. Terret and P.V. Jallepalli.  Meiosis: separase strikes twice.  Nature Cell Biol. 8, 910-911 (2006).

M. Papi, E. Berdougo, C.L. Randall, S. Ganguly, and P.V. Jallepalli.  Multiple roles for separase auto-cleavage during the G2/M transition.  Nature Cell Biol. 7, 1029-1035 (2005).

Z. Wang, J.M. Cummins, D. Shen, D.P. Cahill, P.V. Jallepalli, T.L. Wang, D.W. Parsons, G. Traverso, M. Awad, N. Silliman, J. Ptak, S. Szabo, J.K. Willson, S.D. Markowitz, M.L. Goldberg, R. Karess, K. W. Kinzler, B. Vogelstein, V.E. Velculescu, and C. Lengauer.  Three classes of genes mutated in colorectal cancers with chromosomal instability.  Cancer Res. 64, 2998-3001 (2004).

H. Rajagopalan, P.V. Jallepalli, V.E. Velculescu, K.W. Kinzler, B. Vogelstein, and C. Lengauer.  Inactivation of hCDC4 can cause chromosomal instability.  Nature 428, 77-81 (2004).

P.V. Jallepalli, C. Lengauer, B. Vogelstein, and F. Bunz.  The Chk2 tumor suppressor is not required for p53 responses in human cancer cells.  J. Biol. Chem. 278, 20475-9 (2003).

M.A. Nowak, N.L. Komarova, A. Sengupta, P.V. Jallepalli, I.-E. Shih, B. Vogelstein, and C. Lengauer.  The role of chromosomal instability in tumor initiation.  Proc. Natl. Acad. Sci. USA, 99, 16226-16231 (2002).

P.V. Jallepalli and C. Lengauer.  Chromosome segregation and cancer: cutting through the mystery.  Nature Reviews Cancer 1, 109-117 (2001).

P.V. Jallepalli, I.C. Waizenegger, F. Bunz, S. Langer, M.R. Speicher, J.-M. Peters, K.W. Kinzler, B. Vogelstein, and C. Lengauer.  Securin is required for chromosomal stability in human cells.  Cell 105, 445-457 (2001).