Our laboratory is interested in how human cells accurately duplicate and transmit their chromosomes during each round of division.


M.E. Burkard, C.L. Randall, S. Larochelle, C. Zhang, K.M. Shokat, R.P. Fisher, and P.V. Jallepalli. Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells.  Proc. Natl. Acad. Sci. USA 104, 4383-4388 (2007).

M.E. Burkard, J. Maciejowski, V. Rodriguez-Bravo, M. Repka, D.M. Lowery, K.R. Clauser, C. Zhang, K.M. Shokat, S.A. Carr, M.B. Yaffe, and P.V. Jallepalli.  Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.  PLoS Biol. 7, e1000111 (2009).

M.-F.B. Tsou, W.J. Wang, K.A. George, K. Uryu, T. Stearns, and P.V. Jallepalli.  Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells.  Dev. Cell 17, 344-354 (2009).

M.-E. Terret, R. Sherwood, S. Rahman, J. Qin, and P.V. Jallepalli.  Cohesin acetylation speeds the replication fork.  Nature 462, 231-234 (2009).

J. Maciejowski, K.A. George, M.-E. Terret, C. Zhang, K.M. Shokat, and P.V. Jallepalli. Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.  J. Cell Biol190, 89-100 (2010).

R. Sherwood, T.S. Takahashi, and P.V. Jallepalli.  Sister acts: coordinating DNA replication and cohesion establishment.  Genes Dev. 24, 2723-2731 (2010).

F.S. Oppermann, K. Grundner-Culemann, C. Kumar, O.J. Gruss, P.V. Jallepalli, and H. Daub.  Combination of chemical genetics and phosphoproteomics for kinase signaling analysis enables confident identification of cellular downstream targets.  Mol Cell Proteomics 11, O111.012351 (2012).

V. Rodriguez-Bravo, J. Maciejowski, J. Corona, H.K. Buch, M.T. Kanemaki, J.V. Shah, and P.V. Jallepalli.  Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor.  Cell 156, 1017-1031 (2014).

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Selected Achievements

Phi Beta Kappa, Harvard University (1992)

M.D./Ph.D. Fellow, Medical Scientist Training Program, Johns Hopkins University (1992-1999)

Postdoctoral Fellow, Damon Runyon Cancer Foundation (1999-2002)

Scholar, V Foundation for Cancer Research (2003)

Frederick R. Adler Chair for Junior Faculty (2003-2007)

Pew Scholar in the Biomedical Sciences (2003-2007)

Louise & Allston Boyer Young Investigator Award (2008)

Research Scholar, American Cancer Society (2008-2011)