Renier J. Brentjens, MD, PhD

My laboratory is focused on developing novel treatment approaches for certain leukemias and lymphomas utilizing the patient's own immune system. Specifically this work involves the genetic manipulation of patients' immune cells to recognize and kill their own cancer cells. This is a promising form of gene therapy.

Publications

Brentjens RJ, Davila ML, Riviere I, Park J, Wang X, Cowell LG, Bartido S, Stefanski J, Taylor C, Olszewska M, Borquez-Ojeda O, Qu J, Wasielewska T, He Q, Bernal Y, Rijo IV, Hedvat C, Kobos R, Curran K, Steinherz P, Jurcic J, Rosenblat T, Maslak P, Frattini M, Sadelain M. CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia. Sci Transl Med. 2013 Mar 20;5(177):177ra38. doi: 10.1126/scitranslmed.3005930.

Brentjens et al. Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. Blood. 2012 May 3;119(18):4133-41. doi: 10.1182/blood-2011-12-400044. Epub 2012 Feb 21.

Brentjens et al. Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias.Blood. 2011 Nov 3;118(18):4817-28. doi: 10.1182/blood-2011-04-348540. Epub 2011 Aug 17

Brentjens et al. In vivo inhibition of human CD19-targeted effector T cells by natural T regulatory cells in a xenotransplant murine model of B cell malignancy. Cancer Res. 2011 Apr 15;71(8):2871-81. doi: 10.1158/0008-5472.CAN-10-0552. Epub 2011 Apr 12

Chekmasova AA, Rao TD, Nikhamin Y, Park KJ, Levine DA, Spriggs DR, Brentjens RJ. Successful eradication of established peritoneal ovarian tumors in SCID-Beige mice following adoptive transfer of T cells genetically targeted to the MUC16 antigen. Clin Cancer Res. 2010 Jul 15;16(14):3594-606. doi: 10.1158/1078-0432.CCR Epub 2010 Jul 13.

View Renier J. Brentjens’ physician profile.
Selected Achievements

STRAP Supplemental Award, National Cancer Institute (2010-2013)

William Lawrence Blanche Hughes Foundation Grant (2011-2016)

CLL Global Research Foundation Grant (2009-2014) R01 Award, National Institutes of Health (2009-2014)

Experimental Therapeutics Center Program Project Grant, National Institutes of Health (2009-2014)

Geoffrey Beene Cancer Research Center Fund Award (2007-2009)

Experimental Therapeutics Center Program Project Grant, National Institutes of HEalth (2005-2010)

Clinical Investigator Award, Damon Runyon Foundation (2006-2011)