Molecular Pharmacology Program
The Richard Kolesnick Lab
Research
Richard N. Kolesnick, MD
Our laboratory focuses on the role of sphingolipid signaling as a stress response. In this pathway, generation of the second messenger ceramide in response to diverse environmental and pharmacologic stresses (heat, ionizing radiation, ultraviolet light, chemotherapeutic agents, oxidative challenges, etc.) occurs either by degradation of sphingomyelin or by de novo synthesis. The quality and quantity of the ceramide response, in combination with other signals, determines whether adaptation or apoptosis ensues. This pathway is evolutionarily conserved and is obligate for the heat shock response in yeast.
Research Projects
People
Richard N. Kolesnick, MD
- Physician-scientist Richard Kolesnick studies the role of ceramide signaling in radiation-induced vascular dysfunction and tumor regression.
- MD, University of Chicago School of Medicine
- [email protected]
- Email Address
- 646-888-2174
- Office Phone
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- Physician profile
Members
Visiting Research Scientist
Senior Research Technician
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Graduate Student
SKI Administrative Assistant
Laboratory Manager
Research Fellow
Research Fellow