The mission of the Bioorganic Chemistry Laboratory is to contribute new advances to the strategy and methodology of organic synthesis and to bring them to bear toward progress in problems of biological importance. On the whole, our laboratory performs best when projects challenge the existing state of the art of organic chemistry. These type of “edge-of-the-envelope” challenges engage the interests of some of the most talented young organic chemists in the world. We immerse ourselves in an atmosphere where challenging and thought-provoking organic chemistry is interfaced with issues of plausible biological and medical applications.