Sarat Chandarlapaty: Figures from the Chandarlapaty Laboratory

Negative feedback regulation of growth factor signaling in cancer Negative feedback regulation of growth factor signaling in cancer Are negative feedback modules retained in oncogene driven cancers? In what ways does negative feedback contribute to therapeutic resistance? Does negative feedback exert tumor suppressor functions?
Different modes of negative feedback regulation of PI3K/AKT/mTOR signaling in breast cancer Different modes of negative feedback regulation of PI3K/AKT/mTOR signaling in breast cancer