Sarat Chandarlapaty: Figures from the Chandarlapaty Laboratory

Negative feedback regulation of growth factor signaling in cancer Negative feedback regulation of growth factor signaling in cancer Are negative feedback modules retained in oncogene-driven cancers? In what ways does negative feedback contribute to therapeutic resistance? Does negative feedback exert tumor suppressor functions?
Mutational landscape of hormone refractory, metastatic ER+ breast cancer Mutational landscape of hormone refractory, metastatic ER+ breast cancer What are the consequences of recurrent mutations such as ESR1 and KMT2C on breast cancer pathogenesis?