Steven D. Leach: Publications

Miyamoto Y, Maitra A, Ghosh B, Zechner U, Argani P, Iacobuzio-Donahue CA, Sriuranpong V, Meszoely IM, Wolfe MS, Hruban RH, Ball DW, Schmid RM, Leach SD. Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell 3:565-576, 2003 (supplemental data available at http://www.cell.com/cancer-cell/abstract/S1535-6108(03)00140-5).

Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, Walter K, Nikolskaya T, Nikolsky Y, Hartigan J, Smith DR, Hidalgo M, Leach SD, Klein AP, Jaffee EM, Goggins M, Maitra A, Iacobuzio-Donahue C, Eshleman JR, Kern SE, Hruban RH, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW. Core signaling pathways in human pancreatic cancers revealed by global genomic analysis. Science, 26:1801-1806, 2008.

Rovira M, Scott SG, Liss AS, Jensen J, Thayer SP, Leach SD. Isolation and characterization of centroacinar / terminal ductal progenitor cells in adult mouse pancreas. Proc Natl Acad Sci U S A. 2010; 107:75-80; doi:10.1073/pnas.0912589107.

Rhim, AD, Mirek ET, Aiello NM, Maitra, A, Bailey JM, McAllister F, Reichert M, Beatty GL, Rustgi, AK, Vonderheide RH, Leach SD, Stanger, BZ. EMT and Dissemination Precede Pancreatic Tumor Formation. Cell 148: 349-361; doi 10.1016/j.cell.2011.11.025

Provost E, Wehner KA, Zhong X, Ashar F, Nguyen E, Green RA, Parsons MJ, Leach SD. Ribosomal biogenesis genes play an essential and p53-independent role in pancreas development. Development, 2012 Sep;139(17):3232-41. PMID: 22872088.

Bailey JM, Alsina J, Rasheed ZA, Fu YY, McAllister FM, Zhang H, Pastricha PJ, Matsui W, Maitra A, Leach SD. Dclk1 labels a morphologically distinct cell population with stem cell properties in pre-invasive pancreatic cancer. Gastroenterology, 2013 Oct 2. pii: S0016-5085(13)01411-X. doi: 10.1053/j.gastro.2013.09.050. [Epub ahead of print]

McAllister F, Bailey JM, Alsina J, Nirschl C, Roeser JC, Lankapalli RH, Zhang H, Jaffee EM, Drake CG, Maitra A, Kolls JK, Sears CL, Pardoll DM, Leach SD. Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia. Cancer Cell, 2014, in press.