Thomas Reiner: Publications

2014

Keliher EJ, Klubnick JA, Reiner T, Mazitschek R, Weissleder R (2014) Efficient Acid-Catalyzed F/ F Fluoride Exchange of BODIPY Dyes. ChemMedChem, 2014, published online. doi: 10.1002/cmdc.201300506.

Thurber G, Reiner T, Yang K, Kohler R, Weissleder R (2014) Effect of Small Molecule Modification on Single Cell Pharmacokinetics of PARP Inhibitors. Mol Cancer Ther, 2014 ,published online. doi: 10.1158/1535-7163.MCT-13-0801.

2013

Reiner T, Zeglis BM, The Inverse Electron Demand Diels-Alder Click Reaction in Radiochemistry, Journal of Labelled Compounds and Radiopharmaceuticals, 2013, published online. doi: 10.1002/jlcr.3149.

Emmetiere F, Irwin C, Viola-Villegas NT, Longo V, Cheal SM, Zanzonico P, Pillarsetty N, Weber WA, Lewis JS, Reiner T (2013) 18F-labeled-Bioorthogonal Liposomes for In Vivo Targeting. Bioconjugate chemistry 24:1784–1789.

Jantke D, Marziale AN, Reiner T, Kaus F, Herdtweck E, Raba A, Eppinger J, Synthetic strategies for efficient conjugation of organometallic complexes with pendant protein reactive markers, J Organomet. Chem. 2013, 744:82–91.

Tassa C, Liong M, Hilderbrand S, Sandler JE, Reiner T, Keliher EJ, Weissleder R, Shaw SY, Microfluidic On-Chip Capture-Cycloaddition Reaction to Reversibly Immobilize Small Molecules or Multi-Component Structures for Biosensor Applications. J Vis Exp. 2013, 79:e50772.

Keliher EJ, Reiner T, Earley S, Klubnick J, Tassa C, Ramaswamy S, Bardeesy N, Hanahan D, DePinho RA, Castro CM, Weissleder R, Targeting Pancreatic Cancer by a Small Molecule allows In Vivo Detection. Neoplasia, 2013, 15(7):684-93.

Zeglis BM, Sevak KK, Reiner T, Mohindra P, Carlin SD, Zanzonico P, Weissleder R, Lewis JS, A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels-Alder Click Chemistry, Journal of Nuclear Medicine. 2013 May 24, 54:1-8.

Reiner T, Jantke D, Miao X, Marziale AN, Kiefer F, Eppinger J, Phenylalanine - a biogenic ligand with flexible η6- and η6:κ1-coordination at ruthenium(II) centres. Dalton Transactions. 2013, 42:8692-8703.

Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, Weissleder R (2013) Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat Commun 4:1504.

Reiner T, Jantke D, Marziale AN, Raba A, Eppinger J (2013) Metal‐Conjugated Affinity Labels: A New Concept to Create Enantioselective Artificial Metalloenzymes. ChemistryOpen 2:50–54 –Cover.

2012

Tassa C, Liong M, Hilderbrand S, Sandler JE, Reiner T, Keliher EJ, Weissleder R, Shaw SY (2012) On-chip bioorthogonal chemistry enables immobilization of in situ modified nanoparticles and small molecules for label-free monitoring of protein binding and reaction kinetics. Lab Chip 12:3103–3110.

Chung J, Shao H, Reiner T, Weissleder R, Lee H (2012) Microfluidic Cell Sorter (μFCS) for On‐chip Capture and Analysis of Single Cells. Advanced Healthcare Materials 1:432–436 – Cover.

Reiner T, Lacy J, Keliher EJ, Yang KS, Ullal A, Kohler RH, Vinegoni C, Weissleder R (2012) Imaging therapeutic PARP inhibition in vivo through bioorthogonally developed companion imaging agents. Neoplasia (New York, NY) 14:169–177 – Cover.

Keliher EJ, Reiner T, Thurber GM, Upadhyay R, Weissleder R (2012) Efficient 18F‐Labeling of Synthetic Exendin‐4 Analogues for Imaging Beta Cells. ChemistryOpen 1:177–183.

Yang KS, Budin G, Reiner T, Vinegoni C, Weissleder R (2012) Bioorthogonal imaging of aurora kinase A in live cells. Angewandte Chemie International Edition 51:6598–6603.

2011

Chung HJ, Reiner T, Budin G, Min C, Liong M, Issadore D, Lee H, Weissleder R (2011) Ubiquitous detection of gram-positive bacteria with bioorthogonal magnetofluorescent nanoparticles. ACS Nano 5:8834–8841.

Roberts VM, Stein V, Reiner T, Lemonidou A, Li X, Lercher JA (2011) Towards quantitative catalytic lignin depolymerization. Chemistry 17:5939–5948.

Reiner T, Keliher EJ, Earley S, Marinelli B, Weissleder R (2011) Synthesis and in vivo imaging of a 18F-labeled PARP1 inhibitor using a chemically orthogonal scavenger-assisted high-performance method. Angew Chem Int Ed Engl 50:1922–1925.

Liong M, Fernandez-Suarez M, Issadore D, Min C, Tassa C, Reiner T, Fortune SM, Toner M, Lee H, Weissleder R (2011) Specific pathogen detection using bioorthogonal chemistry and diagnostic magnetic resonance. Bioconjug Chem 22:2390–2394.

Ullal AV, Reiner T, Yang KS, Gorbatov R, Min C, Issadore D, Lee H, Weissleder R (2011) Nanoparticle-mediated measurement of target-drug binding in cancer cells. ACS Nano 5:9216–9224.

Hendricks JA, Keliher EJ, Marinelli B, Reiner T, Weissleder R, Mazitschek R (2011) In Vivo PET Imaging of Histone Deacetylases by (18)F-Suberoylanilide Hydroxamic Acid ((18)F-SAHA). J Med Chem 54:5576–5582.

Keliher EJ, Reiner T, Turetsky A, Hilderbrand SA, Weissleder R (2011) High-yielding, two-step 18F labeling strategy for 18F-PARP1 inhibitors. ChemMedChem 6:424–427.

Budin G, Yang KS, Reiner T, Weissleder R (2011) Bioorthogonal probes for polo-like kinase 1 imaging and quantification. Angew Chem Int Ed Engl 50:9378–9381.

Marziale AN, Jantke D, Faul SH, Reiner T, Herdtweck E, Eppinger J (2011) An efficient protocol for the palladium-catalysed Suzuki–Miyaura cross-coupling. Green Chem 13:169–177.

Reiner T, Thurber G, Gaglia J, Vinegoni C, Liew CW, Upadhyay R, Kohler RH, Li L, Kulkarni RN, Benoist C et al. (2011) Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog. Proc Natl Acad Sci U S A 108:12815–12820.

2010

Reiner T, Waibel M, Marziale AN, Jantke D, Kiefer FJ, Fässler TF, Eppinger J (2010) η6-Arene complexes of ruthenium and osmium with pendant donor functionalities. Journal of Organometallic Chemistry 695:2667–2672.

Reiner T, Kohler RH, Liew CW, Hill JA, Gaglia J, Kulkarni RN, Weissleder R (2010) Near-infrared fluorescent probe for imaging of pancreatic Beta cells. Bioconjug Chem 21:1362–1368.

Marziale AN, Faul SH, Reiner T, Schneider S, Eppinger J (2010) Facile palladium catalyzed Suzuki–Miyaura coupling in air and water at ambient temperature. Green Chemistry 12:35–38 – Inside Cover.

Reiner T, Earley S, Turetsky A, Weissleder R (2010) Bioorthogonal small-molecule ligands for PARP1 imaging in living cells. Chembiochem 11:2374–2377.

2009

Reiner T, Jantke D, Raba A, Marziale AN, Eppinger J (2009) Side chain functionalized η5-tetramethyl cyclopentadienyl complexes of Rh and Ir with a pendant primary amine group. Journal of Organometallic Chemistry 694:1934–1937.

Reiner T, Naraschewski FN, Eppinger J (2009) 31P NMR assays for rapid determination of enantiomeric excess in catalytic hydrosilylations and transfer hydrogenations. Tetrahedron: Asymmetry 20:362–367.